Sevoflurane versus desflurane on the incidence of postreperfusion syndrome during living donor liver transplantation: A randomized controlled trial

Jiwon Lee, Yong Jae Yoo, Jung Man Lee, Young Jae Park, Ho Geol Ryu

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background. Various interventions to reduce postreperfusion syndrome during liver transplantation have been explored, but the effect of volatile anesthetics used during liver transplantation on the incidence of postreperfusion syndrome has not been evaluated. A randomized controlled trial was performed to compare the incidence of postreperfusion syndrome between 2 commonly used volatile anesthetics, sevoflurane and desflurane. Methods. Sixty-two adult liver recipients scheduled for living-donor liver transplantation were randomized to receive either sevoflurane or desflurane for general anesthesia. The incidence of postreperfusion syndrome, use of vasoactive drugs, andpostoperative coursewere compared. The risk factors associated with postreperfusion syndrome were also analyzed. Results. There was significantly less postreperfusion syndrome in the sevoflurane group compared to the desflurane group (38.7% vs 77.4%, P = 0.004) and less epinephrine was required in the sevoflurane group than the desflurane group (19.4% vs 45.2%, P = 0.030). Postoperative intensive care unit and hospital length of stay and postoperative course were similar between the groups. Multivariate analysis identified desflurane (compared to sevoflurane) as the only risk factor (odds ratio 7.314, P = 0.001) for reperfusion syndrome. Conclusions. When using volatile anesthetics for elective living donor liver transplantation, sevoflurane seems to be a better option than desflurane for reducing the incidence of postreperfusion syndrome.

Original languageEnglish
Pages (from-to)600-606
Number of pages7
JournalTransplantation
Volume100
Issue number3
DOIs
StatePublished - 1 Jan 2016

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