Severity of dental caries and risk of coronary heart disease in middle-aged men and women

a population-based cohort study of Korean adults, 2002–2013

Kyuwoong Kim, Seulggie Choi, Jooyoung Chang, Sung Min Kim, Seon Jip Kim, Ryan Jin Young Kim, Hyun Jae Cho, Sangmin Park

Research output: Contribution to journalArticleResearchpeer-review

Abstract

We aimed to evaluate the risk of coronary heart disease (CHD) according to dental caries status in middle-aged patients using a population-based cohort database containing medical/dental claims, health examination, and death records in the Republic of Korea. A total of 234,597 patients were identified in the database who were without history of cardiovascular disease, including 104,638 patients without dental caries, 41,696 with incipient/moderate stage dental caries, and 88,262 advanced/severe dental caries. We used Cox proportional hazards model adjusted for sociodemographic, lifestyle, and medical characteristics to compute hazard ratio (HR) and 95% confidence intervals (95% CI) for CHD according to severity of dental caries. During 1,491,190 person-years of follow-up, there were a total of 6,015 CHD events. After adjustment for potential confounders, patients in the highest quartile of outpatient visits for advanced/severe stage dental caries was associated with an increase in CHD risk (HR = 1.13; 95% CI: 1.04–1.22) as compared with patients without dental caries. When the analysis was restricted to the patients with advanced/severe dental caries, dose-response relationship between number of outpatient visits for dental caries and risk of CHD was observed (Ptrend: <0.001). Prevention and control of dental caries might be worth promoting in clinical practice to prevent CHD.

Original languageEnglish
Article number10491
JournalScientific Reports
Volume9
Issue number1
DOIs
StatePublished - 1 Dec 2019

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Dental Caries
Coronary Disease
Cohort Studies
Population
Outpatients
Databases
Confidence Intervals
Republic of Korea
Death Certificates
Proportional Hazards Models
Life Style
Tooth
Cardiovascular Diseases
Odds Ratio
Health

Cite this

Kim, Kyuwoong ; Choi, Seulggie ; Chang, Jooyoung ; Kim, Sung Min ; Kim, Seon Jip ; Kim, Ryan Jin Young ; Cho, Hyun Jae ; Park, Sangmin. / Severity of dental caries and risk of coronary heart disease in middle-aged men and women : a population-based cohort study of Korean adults, 2002–2013. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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abstract = "We aimed to evaluate the risk of coronary heart disease (CHD) according to dental caries status in middle-aged patients using a population-based cohort database containing medical/dental claims, health examination, and death records in the Republic of Korea. A total of 234,597 patients were identified in the database who were without history of cardiovascular disease, including 104,638 patients without dental caries, 41,696 with incipient/moderate stage dental caries, and 88,262 advanced/severe dental caries. We used Cox proportional hazards model adjusted for sociodemographic, lifestyle, and medical characteristics to compute hazard ratio (HR) and 95{\%} confidence intervals (95{\%} CI) for CHD according to severity of dental caries. During 1,491,190 person-years of follow-up, there were a total of 6,015 CHD events. After adjustment for potential confounders, patients in the highest quartile of outpatient visits for advanced/severe stage dental caries was associated with an increase in CHD risk (HR = 1.13; 95{\%} CI: 1.04–1.22) as compared with patients without dental caries. When the analysis was restricted to the patients with advanced/severe dental caries, dose-response relationship between number of outpatient visits for dental caries and risk of CHD was observed (Ptrend: <0.001). Prevention and control of dental caries might be worth promoting in clinical practice to prevent CHD.",
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Severity of dental caries and risk of coronary heart disease in middle-aged men and women : a population-based cohort study of Korean adults, 2002–2013. / Kim, Kyuwoong; Choi, Seulggie; Chang, Jooyoung; Kim, Sung Min; Kim, Seon Jip; Kim, Ryan Jin Young; Cho, Hyun Jae; Park, Sangmin.

In: Scientific Reports, Vol. 9, No. 1, 10491, 01.12.2019.

Research output: Contribution to journalArticleResearchpeer-review

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