Serum carotenoid levels and risk of lung cancer death in US adults

Kyoung-Bok Min, Jin young Min

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

Lung cancer is one of the most common cancers worldwide and is the leading cause of cancer-induced death in the USA. Although much attention has been focused on the anti-carcinogenic effect of consuming carotenoid-containing food or supplements, the results have been inconsistent. We investigated whether serum carotenoid levels were associated with the mortality risk of lung cancer in US adults using data from a nationally representative sample. The data were obtained from the Third Nutrition and Health Examination Survey (NHANES III) database and the NHANES III Linked Mortality File. A total of 10 382 participants aged over 20 years with available serum carotenoid levels and no other missing information on questionnaires and biomarkers at baseline (NHANES III) were included in the present study. Of the 10 382 participants, 161 subjects died due to lung cancer. We found that high serum levels of alpha-carotene and beta-cryptoxanthin at baseline were significantly associated with a lower risk of lung cancer death. When we stratified the risk by current smoking status, the risk of death of current smokers was significantly decreased to 46% (95% confidence interval, 31-94%) for alpha-carotene and 61% (95% confidence interval, 19-80%) for beta-cryptoxanthin. By contrast, no association was observed among never/former smokers at baseline. High serum levels of alpha-carotene and beta-cryptoxanthin are associated with a lower risk of lung cancer death in US adults. High serum levels of alpha-carotene and beta-cryptoxanthin at baseline were significantly associated with a lower risk of lung cancer mortality after adjustment for potential covariates.The mortality risk of current smokers was significantly decreased to 46% (95% CI, 0.31-0.94) for alpha-carotene and 61% (95% CI, 0.19-0.80) for beta-cryptoxanthin, respectively. By contrast, no association was observed among never/former smokers at baseline.

Original languageEnglish
Pages (from-to)736-743
Number of pages8
JournalCancer Science
Volume105
Issue number6
DOIs
StatePublished - 1 Jan 2014

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Carotenoids
Lung Neoplasms
Serum
Nutrition Surveys
Mortality
Anticarcinogenic Agents
Confidence Intervals
Dietary Supplements
Health Surveys
Neoplasms
Biomarkers
Smoking
Beta-Cryptoxanthin
alpha-carotene
Databases

Keywords

  • Alpha-carotene
  • Beta-cryptoxanthin
  • Lung cancer
  • Oxidative stress
  • Smoking

Cite this

Min, Kyoung-Bok ; Min, Jin young. / Serum carotenoid levels and risk of lung cancer death in US adults. In: Cancer Science. 2014 ; Vol. 105, No. 6. pp. 736-743.
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abstract = "Lung cancer is one of the most common cancers worldwide and is the leading cause of cancer-induced death in the USA. Although much attention has been focused on the anti-carcinogenic effect of consuming carotenoid-containing food or supplements, the results have been inconsistent. We investigated whether serum carotenoid levels were associated with the mortality risk of lung cancer in US adults using data from a nationally representative sample. The data were obtained from the Third Nutrition and Health Examination Survey (NHANES III) database and the NHANES III Linked Mortality File. A total of 10 382 participants aged over 20 years with available serum carotenoid levels and no other missing information on questionnaires and biomarkers at baseline (NHANES III) were included in the present study. Of the 10 382 participants, 161 subjects died due to lung cancer. We found that high serum levels of alpha-carotene and beta-cryptoxanthin at baseline were significantly associated with a lower risk of lung cancer death. When we stratified the risk by current smoking status, the risk of death of current smokers was significantly decreased to 46{\%} (95{\%} confidence interval, 31-94{\%}) for alpha-carotene and 61{\%} (95{\%} confidence interval, 19-80{\%}) for beta-cryptoxanthin. By contrast, no association was observed among never/former smokers at baseline. High serum levels of alpha-carotene and beta-cryptoxanthin are associated with a lower risk of lung cancer death in US adults. High serum levels of alpha-carotene and beta-cryptoxanthin at baseline were significantly associated with a lower risk of lung cancer mortality after adjustment for potential covariates.The mortality risk of current smokers was significantly decreased to 46{\%} (95{\%} CI, 0.31-0.94) for alpha-carotene and 61{\%} (95{\%} CI, 0.19-0.80) for beta-cryptoxanthin, respectively. By contrast, no association was observed among never/former smokers at baseline.",
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Serum carotenoid levels and risk of lung cancer death in US adults. / Min, Kyoung-Bok; Min, Jin young.

In: Cancer Science, Vol. 105, No. 6, 01.01.2014, p. 736-743.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Min, Jin young

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N2 - Lung cancer is one of the most common cancers worldwide and is the leading cause of cancer-induced death in the USA. Although much attention has been focused on the anti-carcinogenic effect of consuming carotenoid-containing food or supplements, the results have been inconsistent. We investigated whether serum carotenoid levels were associated with the mortality risk of lung cancer in US adults using data from a nationally representative sample. The data were obtained from the Third Nutrition and Health Examination Survey (NHANES III) database and the NHANES III Linked Mortality File. A total of 10 382 participants aged over 20 years with available serum carotenoid levels and no other missing information on questionnaires and biomarkers at baseline (NHANES III) were included in the present study. Of the 10 382 participants, 161 subjects died due to lung cancer. We found that high serum levels of alpha-carotene and beta-cryptoxanthin at baseline were significantly associated with a lower risk of lung cancer death. When we stratified the risk by current smoking status, the risk of death of current smokers was significantly decreased to 46% (95% confidence interval, 31-94%) for alpha-carotene and 61% (95% confidence interval, 19-80%) for beta-cryptoxanthin. By contrast, no association was observed among never/former smokers at baseline. High serum levels of alpha-carotene and beta-cryptoxanthin are associated with a lower risk of lung cancer death in US adults. High serum levels of alpha-carotene and beta-cryptoxanthin at baseline were significantly associated with a lower risk of lung cancer mortality after adjustment for potential covariates.The mortality risk of current smokers was significantly decreased to 46% (95% CI, 0.31-0.94) for alpha-carotene and 61% (95% CI, 0.19-0.80) for beta-cryptoxanthin, respectively. By contrast, no association was observed among never/former smokers at baseline.

AB - Lung cancer is one of the most common cancers worldwide and is the leading cause of cancer-induced death in the USA. Although much attention has been focused on the anti-carcinogenic effect of consuming carotenoid-containing food or supplements, the results have been inconsistent. We investigated whether serum carotenoid levels were associated with the mortality risk of lung cancer in US adults using data from a nationally representative sample. The data were obtained from the Third Nutrition and Health Examination Survey (NHANES III) database and the NHANES III Linked Mortality File. A total of 10 382 participants aged over 20 years with available serum carotenoid levels and no other missing information on questionnaires and biomarkers at baseline (NHANES III) were included in the present study. Of the 10 382 participants, 161 subjects died due to lung cancer. We found that high serum levels of alpha-carotene and beta-cryptoxanthin at baseline were significantly associated with a lower risk of lung cancer death. When we stratified the risk by current smoking status, the risk of death of current smokers was significantly decreased to 46% (95% confidence interval, 31-94%) for alpha-carotene and 61% (95% confidence interval, 19-80%) for beta-cryptoxanthin. By contrast, no association was observed among never/former smokers at baseline. High serum levels of alpha-carotene and beta-cryptoxanthin are associated with a lower risk of lung cancer death in US adults. High serum levels of alpha-carotene and beta-cryptoxanthin at baseline were significantly associated with a lower risk of lung cancer mortality after adjustment for potential covariates.The mortality risk of current smokers was significantly decreased to 46% (95% CI, 0.31-0.94) for alpha-carotene and 61% (95% CI, 0.19-0.80) for beta-cryptoxanthin, respectively. By contrast, no association was observed among never/former smokers at baseline.

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