Serotype Distribution and Antimicrobial Resistance of Invasive and Noninvasive Streptococcus pneumoniae Isolates in Korea between 2014 and 2016

Dong Chul Park, Si Hyun Kim, Dongeun Yong, In Bum Suh, Young Ree Kim, Jongyoun Yi, Wonkeun Song, Sae Am Song, Hee Won Moon, Hae Kyung Lee, Kyoung Un Park, Sunjoo Kim, Seok Hoon Jeong, Jaehyeon Lee, Joseph Jeong, Yu Kyung Kim, Miae Lee, Jihyun Cho, Jong Wan Kim, Kyeong Seob Shin & 22 others Sang Hyun Hwang, Jae Woo Chung, Hye In Woo, Chae Hoon Lee, Namhee Ryoo, Chulhun L. Chang, Hyun Soo Kim, Jayoung Kim, Jong Hee Shin, Soo Hyun Kim, Mi Kyung Lee, Seong Gyu Lee, Sook Jin Jang, Kyutaeg Lee, Hun Suk Suh, Yong Hak Sohn, Min Jung Kwon, Hee Joo Lee, Ki Ho Hong, Kwang Sook Woo, Chul Min Park, Jeong Hwan Shin

Research output: Contribution to journalArticleResearchpeer-review

Abstract

BACKGROUND: Several factors contribute to differences in Streptococcus pneumoniae serotype distribution. We investigated the serotype distribution and antimicrobial resistance of S. pneumoniae isolated between 2014 and 2016 in Korea.

METHODS: We collected a total of 1,855 S. pneumoniae isolates from 44 hospitals between May 2014 and May 2016, and analyzed the serotypes by sequential multiplex PCR. We investigated the distribution of each serotype by patient age, source of the clinical specimen, and antimicrobial resistance pattern.

RESULTS: The most common serotypes were 11A (10.1%), followed by 19A (8.8%), 3 (8.5%), 34 (8.1%), 23A (7.3%), and 35B (6.2%). The major invasive serotypes were 3 (12.6%), 19A (7.8%), 34 (7.8%), 10A (6.8%), and 11A (6.8%). Serotypes 10A, 15B, 19A, and 12F were more common in patients ≤5 years old, while serotype 3 was more common in patients ≥65 years old compared with the other age groups. The coverage rates of pneumococcal conjugate vaccine (PCV)7, PCV10, PCV13, and pneumococcal polysaccharide vaccine 23 were 11.8%, 12.12%, 33.3%, and 53.6%, respectively. Of the 1,855 isolates, 857 (46.2%) were multi-drug resistant (MDR), with serotypes 11A and 19A predominant among the MDR strains. The resistance rates against penicillin, cefotaxime, and levofloxacin were 22.8%, 12.5%, and 9.4%, respectively.

CONCLUSIONS: There were significant changes in the major S. pneumoniae serotypes in the community. Non-PCV13 serotypes increased in patients ≤5 years old following the introduction of national immunization programs with the 10- and 13-polyvalent vaccines.

Original languageEnglish
Pages (from-to)537-544
Number of pages8
JournalAnnals of laboratory medicine
Volume39
Issue number6
DOIs
StatePublished - 1 Nov 2019

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Korea
Streptococcus pneumoniae
Immunization
Conjugate Vaccines
Pneumococcal Vaccines
Levofloxacin
Cefotaxime
Penicillins
Pharmaceutical Preparations
Vaccines
Serogroup
Immunization Programs
Multiplex Polymerase Chain Reaction
10-valent pneumococcal conjugate vaccine
Age Groups

Keywords

  • Antimicrobial resistance
  • Pneumococcal vaccine
  • Serotype
  • Streptococcus pneumoniae

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Park, Dong Chul ; Kim, Si Hyun ; Yong, Dongeun ; Suh, In Bum ; Kim, Young Ree ; Yi, Jongyoun ; Song, Wonkeun ; Song, Sae Am ; Moon, Hee Won ; Lee, Hae Kyung ; Park, Kyoung Un ; Kim, Sunjoo ; Jeong, Seok Hoon ; Lee, Jaehyeon ; Jeong, Joseph ; Kim, Yu Kyung ; Lee, Miae ; Cho, Jihyun ; Kim, Jong Wan ; Shin, Kyeong Seob ; Hwang, Sang Hyun ; Chung, Jae Woo ; Woo, Hye In ; Lee, Chae Hoon ; Ryoo, Namhee ; Chang, Chulhun L. ; Kim, Hyun Soo ; Kim, Jayoung ; Shin, Jong Hee ; Kim, Soo Hyun ; Lee, Mi Kyung ; Lee, Seong Gyu ; Jang, Sook Jin ; Lee, Kyutaeg ; Suh, Hun Suk ; Sohn, Yong Hak ; Kwon, Min Jung ; Lee, Hee Joo ; Hong, Ki Ho ; Woo, Kwang Sook ; Park, Chul Min ; Shin, Jeong Hwan. / Serotype Distribution and Antimicrobial Resistance of Invasive and Noninvasive Streptococcus pneumoniae Isolates in Korea between 2014 and 2016. In: Annals of laboratory medicine. 2019 ; Vol. 39, No. 6. pp. 537-544.
@article{bf57f1c36851467f9b02a2b2d06f6ee2,
title = "Serotype Distribution and Antimicrobial Resistance of Invasive and Noninvasive Streptococcus pneumoniae Isolates in Korea between 2014 and 2016",
abstract = "BACKGROUND: Several factors contribute to differences in Streptococcus pneumoniae serotype distribution. We investigated the serotype distribution and antimicrobial resistance of S. pneumoniae isolated between 2014 and 2016 in Korea.METHODS: We collected a total of 1,855 S. pneumoniae isolates from 44 hospitals between May 2014 and May 2016, and analyzed the serotypes by sequential multiplex PCR. We investigated the distribution of each serotype by patient age, source of the clinical specimen, and antimicrobial resistance pattern.RESULTS: The most common serotypes were 11A (10.1{\%}), followed by 19A (8.8{\%}), 3 (8.5{\%}), 34 (8.1{\%}), 23A (7.3{\%}), and 35B (6.2{\%}). The major invasive serotypes were 3 (12.6{\%}), 19A (7.8{\%}), 34 (7.8{\%}), 10A (6.8{\%}), and 11A (6.8{\%}). Serotypes 10A, 15B, 19A, and 12F were more common in patients ≤5 years old, while serotype 3 was more common in patients ≥65 years old compared with the other age groups. The coverage rates of pneumococcal conjugate vaccine (PCV)7, PCV10, PCV13, and pneumococcal polysaccharide vaccine 23 were 11.8{\%}, 12.12{\%}, 33.3{\%}, and 53.6{\%}, respectively. Of the 1,855 isolates, 857 (46.2{\%}) were multi-drug resistant (MDR), with serotypes 11A and 19A predominant among the MDR strains. The resistance rates against penicillin, cefotaxime, and levofloxacin were 22.8{\%}, 12.5{\%}, and 9.4{\%}, respectively.CONCLUSIONS: There were significant changes in the major S. pneumoniae serotypes in the community. Non-PCV13 serotypes increased in patients ≤5 years old following the introduction of national immunization programs with the 10- and 13-polyvalent vaccines.",
keywords = "Antimicrobial resistance, Pneumococcal vaccine, Serotype, Streptococcus pneumoniae",
author = "Park, {Dong Chul} and Kim, {Si Hyun} and Dongeun Yong and Suh, {In Bum} and Kim, {Young Ree} and Jongyoun Yi and Wonkeun Song and Song, {Sae Am} and Moon, {Hee Won} and Lee, {Hae Kyung} and Park, {Kyoung Un} and Sunjoo Kim and Jeong, {Seok Hoon} and Jaehyeon Lee and Joseph Jeong and Kim, {Yu Kyung} and Miae Lee and Jihyun Cho and Kim, {Jong Wan} and Shin, {Kyeong Seob} and Hwang, {Sang Hyun} and Chung, {Jae Woo} and Woo, {Hye In} and Lee, {Chae Hoon} and Namhee Ryoo and Chang, {Chulhun L.} and Kim, {Hyun Soo} and Jayoung Kim and Shin, {Jong Hee} and Kim, {Soo Hyun} and Lee, {Mi Kyung} and Lee, {Seong Gyu} and Jang, {Sook Jin} and Kyutaeg Lee and Suh, {Hun Suk} and Sohn, {Yong Hak} and Kwon, {Min Jung} and Lee, {Hee Joo} and Hong, {Ki Ho} and Woo, {Kwang Sook} and Park, {Chul Min} and Shin, {Jeong Hwan}",
note = "{\circledC} The Korean Society for Laboratory Medicine.",
year = "2019",
month = "11",
day = "1",
doi = "10.3343/alm.2019.39.6.537",
language = "English",
volume = "39",
pages = "537--544",
journal = "Annals of Laboratory Medicine",
issn = "2234-3806",
publisher = "Seoul National University",
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Park, DC, Kim, SH, Yong, D, Suh, IB, Kim, YR, Yi, J, Song, W, Song, SA, Moon, HW, Lee, HK, Park, KU, Kim, S, Jeong, SH, Lee, J, Jeong, J, Kim, YK, Lee, M, Cho, J, Kim, JW, Shin, KS, Hwang, SH, Chung, JW, Woo, HI, Lee, CH, Ryoo, N, Chang, CL, Kim, HS, Kim, J, Shin, JH, Kim, SH, Lee, MK, Lee, SG, Jang, SJ, Lee, K, Suh, HS, Sohn, YH, Kwon, MJ, Lee, HJ, Hong, KH, Woo, KS, Park, CM & Shin, JH 2019, 'Serotype Distribution and Antimicrobial Resistance of Invasive and Noninvasive Streptococcus pneumoniae Isolates in Korea between 2014 and 2016', Annals of laboratory medicine, vol. 39, no. 6, pp. 537-544. https://doi.org/10.3343/alm.2019.39.6.537, https://doi.org/10.3343/alm.2019.39.6.537

Serotype Distribution and Antimicrobial Resistance of Invasive and Noninvasive Streptococcus pneumoniae Isolates in Korea between 2014 and 2016. / Park, Dong Chul; Kim, Si Hyun; Yong, Dongeun; Suh, In Bum; Kim, Young Ree; Yi, Jongyoun; Song, Wonkeun; Song, Sae Am; Moon, Hee Won; Lee, Hae Kyung; Park, Kyoung Un; Kim, Sunjoo; Jeong, Seok Hoon; Lee, Jaehyeon; Jeong, Joseph; Kim, Yu Kyung; Lee, Miae; Cho, Jihyun; Kim, Jong Wan; Shin, Kyeong Seob; Hwang, Sang Hyun; Chung, Jae Woo; Woo, Hye In; Lee, Chae Hoon; Ryoo, Namhee; Chang, Chulhun L.; Kim, Hyun Soo; Kim, Jayoung; Shin, Jong Hee; Kim, Soo Hyun; Lee, Mi Kyung; Lee, Seong Gyu; Jang, Sook Jin; Lee, Kyutaeg; Suh, Hun Suk; Sohn, Yong Hak; Kwon, Min Jung; Lee, Hee Joo; Hong, Ki Ho; Woo, Kwang Sook; Park, Chul Min; Shin, Jeong Hwan.

In: Annals of laboratory medicine, Vol. 39, No. 6, 01.11.2019, p. 537-544.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Serotype Distribution and Antimicrobial Resistance of Invasive and Noninvasive Streptococcus pneumoniae Isolates in Korea between 2014 and 2016

AU - Park, Dong Chul

AU - Kim, Si Hyun

AU - Yong, Dongeun

AU - Suh, In Bum

AU - Kim, Young Ree

AU - Yi, Jongyoun

AU - Song, Wonkeun

AU - Song, Sae Am

AU - Moon, Hee Won

AU - Lee, Hae Kyung

AU - Park, Kyoung Un

AU - Kim, Sunjoo

AU - Jeong, Seok Hoon

AU - Lee, Jaehyeon

AU - Jeong, Joseph

AU - Kim, Yu Kyung

AU - Lee, Miae

AU - Cho, Jihyun

AU - Kim, Jong Wan

AU - Shin, Kyeong Seob

AU - Hwang, Sang Hyun

AU - Chung, Jae Woo

AU - Woo, Hye In

AU - Lee, Chae Hoon

AU - Ryoo, Namhee

AU - Chang, Chulhun L.

AU - Kim, Hyun Soo

AU - Kim, Jayoung

AU - Shin, Jong Hee

AU - Kim, Soo Hyun

AU - Lee, Mi Kyung

AU - Lee, Seong Gyu

AU - Jang, Sook Jin

AU - Lee, Kyutaeg

AU - Suh, Hun Suk

AU - Sohn, Yong Hak

AU - Kwon, Min Jung

AU - Lee, Hee Joo

AU - Hong, Ki Ho

AU - Woo, Kwang Sook

AU - Park, Chul Min

AU - Shin, Jeong Hwan

N1 - © The Korean Society for Laboratory Medicine.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - BACKGROUND: Several factors contribute to differences in Streptococcus pneumoniae serotype distribution. We investigated the serotype distribution and antimicrobial resistance of S. pneumoniae isolated between 2014 and 2016 in Korea.METHODS: We collected a total of 1,855 S. pneumoniae isolates from 44 hospitals between May 2014 and May 2016, and analyzed the serotypes by sequential multiplex PCR. We investigated the distribution of each serotype by patient age, source of the clinical specimen, and antimicrobial resistance pattern.RESULTS: The most common serotypes were 11A (10.1%), followed by 19A (8.8%), 3 (8.5%), 34 (8.1%), 23A (7.3%), and 35B (6.2%). The major invasive serotypes were 3 (12.6%), 19A (7.8%), 34 (7.8%), 10A (6.8%), and 11A (6.8%). Serotypes 10A, 15B, 19A, and 12F were more common in patients ≤5 years old, while serotype 3 was more common in patients ≥65 years old compared with the other age groups. The coverage rates of pneumococcal conjugate vaccine (PCV)7, PCV10, PCV13, and pneumococcal polysaccharide vaccine 23 were 11.8%, 12.12%, 33.3%, and 53.6%, respectively. Of the 1,855 isolates, 857 (46.2%) were multi-drug resistant (MDR), with serotypes 11A and 19A predominant among the MDR strains. The resistance rates against penicillin, cefotaxime, and levofloxacin were 22.8%, 12.5%, and 9.4%, respectively.CONCLUSIONS: There were significant changes in the major S. pneumoniae serotypes in the community. Non-PCV13 serotypes increased in patients ≤5 years old following the introduction of national immunization programs with the 10- and 13-polyvalent vaccines.

AB - BACKGROUND: Several factors contribute to differences in Streptococcus pneumoniae serotype distribution. We investigated the serotype distribution and antimicrobial resistance of S. pneumoniae isolated between 2014 and 2016 in Korea.METHODS: We collected a total of 1,855 S. pneumoniae isolates from 44 hospitals between May 2014 and May 2016, and analyzed the serotypes by sequential multiplex PCR. We investigated the distribution of each serotype by patient age, source of the clinical specimen, and antimicrobial resistance pattern.RESULTS: The most common serotypes were 11A (10.1%), followed by 19A (8.8%), 3 (8.5%), 34 (8.1%), 23A (7.3%), and 35B (6.2%). The major invasive serotypes were 3 (12.6%), 19A (7.8%), 34 (7.8%), 10A (6.8%), and 11A (6.8%). Serotypes 10A, 15B, 19A, and 12F were more common in patients ≤5 years old, while serotype 3 was more common in patients ≥65 years old compared with the other age groups. The coverage rates of pneumococcal conjugate vaccine (PCV)7, PCV10, PCV13, and pneumococcal polysaccharide vaccine 23 were 11.8%, 12.12%, 33.3%, and 53.6%, respectively. Of the 1,855 isolates, 857 (46.2%) were multi-drug resistant (MDR), with serotypes 11A and 19A predominant among the MDR strains. The resistance rates against penicillin, cefotaxime, and levofloxacin were 22.8%, 12.5%, and 9.4%, respectively.CONCLUSIONS: There were significant changes in the major S. pneumoniae serotypes in the community. Non-PCV13 serotypes increased in patients ≤5 years old following the introduction of national immunization programs with the 10- and 13-polyvalent vaccines.

KW - Antimicrobial resistance

KW - Pneumococcal vaccine

KW - Serotype

KW - Streptococcus pneumoniae

UR - http://www.scopus.com/inward/record.url?scp=85068855860&partnerID=8YFLogxK

U2 - 10.3343/alm.2019.39.6.537

DO - 10.3343/alm.2019.39.6.537

M3 - Article

VL - 39

SP - 537

EP - 544

JO - Annals of Laboratory Medicine

JF - Annals of Laboratory Medicine

SN - 2234-3806

IS - 6

ER -