Serologic detection of Middle East respiratory syndrome coronavirus functional antibodies

Nisreen M.A. Okba, Ivy Widjaja, Wentao Li, Corine H. GeurtsvanKessel, Elmoubasher A.B.A. Farag, Mohammed Al-Hajri, Wan Beom Park, Myoung Don Oh, Chantal B.E.M. Reusken, Marion P.G. Koopmans, Berend Jan Bosch, Bart L. Haagmans

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.

Original languageEnglish
Pages (from-to)1024-1027
Number of pages4
JournalEmerging infectious diseases
Volume26
Issue number5
DOIs
StatePublished - May 2020

    Fingerprint

Cite this

Okba, N. M. A., Widjaja, I., Li, W., GeurtsvanKessel, C. H., Farag, E. A. B. A., Al-Hajri, M., Park, W. B., Oh, M. D., Reusken, C. B. E. M., Koopmans, M. P. G., Bosch, B. J., & Haagmans, B. L. (2020). Serologic detection of Middle East respiratory syndrome coronavirus functional antibodies. Emerging infectious diseases, 26(5), 1024-1027. https://doi.org/10.3201/eid2605.190921