Sequential emergence and wide spread of neutralization escape middle east respiratory syndrome coronavirus mutants, South Korea, 2015

Yeon Sook Kim, Abdimadiyeva Aigerim, Uni Park, Yuri Kim, Ji Young Rhee, Jae Phil Choi, Wan Beom Park, Sang-Won Park, Yeonjae Kim, Dong Gyun Lim, Kyung Soo Inn, Eung Soo Hwang, Myungsik Choi, Hyoung Shik Shin, Nam Hyuk Cho

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The unexpectedly large outbreak of Middle East respiratory syndrome in South Korea in 2015 was initiated by an infected traveler and amplified by several “superspreading” events. Previously, we reported the emergence and spread of mutant Middle East respiratory syndrome coronavirus bearing spike mutations (I529T or D510G) with reduced affinity to human receptor CD26 during the outbreak. To assess the potential association of spike mutations with superspreading events, we collected virus genetic information reported during the outbreak and systemically analyzed the relationship of spike sequences and epidemiology. We found sequential emergence of the spike mutations in 2 superspreaders. In vivo virulence of the mutant viruses seems to decline in human patients, as assessed by fever duration in affected persons. In addition, neutralizing activity against these 2 mutant viruses in serum samples from mice immunized with wild-type spike antigen were gradually reduced, suggesting emergence and wide spread of neutralization escapers during the outbreak.

Original languageEnglish
Pages (from-to)1161-1168
Number of pages8
JournalEmerging infectious diseases
Volume25
Issue number6
DOIs
StatePublished - 1 Jun 2019

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Republic of Korea
Disease Outbreaks
Viruses
Mutation
Coronavirus Infections
Action Potentials
Virulence
Epidemiology
Fever
Antigens
Middle East Respiratory Syndrome Coronavirus
Serum

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Kim, Yeon Sook ; Aigerim, Abdimadiyeva ; Park, Uni ; Kim, Yuri ; Rhee, Ji Young ; Choi, Jae Phil ; Park, Wan Beom ; Park, Sang-Won ; Kim, Yeonjae ; Lim, Dong Gyun ; Inn, Kyung Soo ; Hwang, Eung Soo ; Choi, Myungsik ; Shin, Hyoung Shik ; Cho, Nam Hyuk. / Sequential emergence and wide spread of neutralization escape middle east respiratory syndrome coronavirus mutants, South Korea, 2015. In: Emerging infectious diseases. 2019 ; Vol. 25, No. 6. pp. 1161-1168.
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abstract = "The unexpectedly large outbreak of Middle East respiratory syndrome in South Korea in 2015 was initiated by an infected traveler and amplified by several “superspreading” events. Previously, we reported the emergence and spread of mutant Middle East respiratory syndrome coronavirus bearing spike mutations (I529T or D510G) with reduced affinity to human receptor CD26 during the outbreak. To assess the potential association of spike mutations with superspreading events, we collected virus genetic information reported during the outbreak and systemically analyzed the relationship of spike sequences and epidemiology. We found sequential emergence of the spike mutations in 2 superspreaders. In vivo virulence of the mutant viruses seems to decline in human patients, as assessed by fever duration in affected persons. In addition, neutralizing activity against these 2 mutant viruses in serum samples from mice immunized with wild-type spike antigen were gradually reduced, suggesting emergence and wide spread of neutralization escapers during the outbreak.",
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Sequential emergence and wide spread of neutralization escape middle east respiratory syndrome coronavirus mutants, South Korea, 2015. / Kim, Yeon Sook; Aigerim, Abdimadiyeva; Park, Uni; Kim, Yuri; Rhee, Ji Young; Choi, Jae Phil; Park, Wan Beom; Park, Sang-Won; Kim, Yeonjae; Lim, Dong Gyun; Inn, Kyung Soo; Hwang, Eung Soo; Choi, Myungsik; Shin, Hyoung Shik; Cho, Nam Hyuk.

In: Emerging infectious diseases, Vol. 25, No. 6, 01.06.2019, p. 1161-1168.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Choi, Jae Phil

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AU - Park, Sang-Won

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AU - Lim, Dong Gyun

AU - Inn, Kyung Soo

AU - Hwang, Eung Soo

AU - Choi, Myungsik

AU - Shin, Hyoung Shik

AU - Cho, Nam Hyuk

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