Selenium enhances the efficacy of Radachlorin mediated-photodynamic therapy in cervical cancer model

Dong Han Bae, Lan Ying Wen, Su Mi Bae, Uk Kang, Keun Hee Kim, Sanghoon Jheon, Jeongsang Lee, Woong Shick Ahn

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Abstract

Selenium, an essential trace element possessing anti-carcinogenic properties, can induce apoptosis in cancer cells. Our goal was to investigate the enhanced anti-tumor effects of photodynamic therapy (PDT) plus selenium in TC-1 tumor cells implanted into mice. The MTT assay and tumor growth inhibition study were evaluated at various time intervals after the PDT plus a various dose of selenium. Following Radachlorin injections after 3 hr, the mice were then administrated selenium (2ug/kg b.w.) and then, tumors were treated with external light treatment (300 J/cm2). The selenium was administered daily for 20 days. PDT or selenium was found to be more compared to control groups. Moreover, the PDT combined with selenium demonstrated a significant suppression of tumor growth in vitro and in vivo. The tumor growth by the PDT combined with selenium was significantly reduced. These data suggest that selenium plus PDT can induce a significant tumor suppression response compared with PDT alone. Also, it can be an effective approach to induce anti-cancer therapy strategy.

Original languageEnglish
Title of host publication12th World Congress of the International Photodynamic Association - Photodynamic Therapy
Subtitle of host publicationBack to the Future
Volume7380
DOIs
StatePublished - 1 Dec 2009
Event12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future - Seattle, WA, United States
Duration: 11 Jun 200915 Jun 2009

Other

Other12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future
CountryUnited States
CitySeattle, WA
Period11/06/0915/06/09

Fingerprint

Photodynamic therapy
Photochemotherapy
Selenium
selenium
Uterine Cervical Neoplasms
therapy
cancer
Tumors
tumors
Neoplasms
mice
Growth
Cells
retarding
Hairless Mouse
bremachlorin
Trace Elements
apoptosis
Cell death
Trace elements

Keywords

  • cervical cancer model
  • photodynamic therapy
  • Selenium
  • TC-1 cells

Cite this

Bae, D. H., Wen, L. Y., Bae, S. M., Kang, U., Kim, K. H., Jheon, S., ... Ahn, W. S. (2009). Selenium enhances the efficacy of Radachlorin mediated-photodynamic therapy in cervical cancer model. In 12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future (Vol. 7380). [73802T] https://doi.org/10.1117/12.824242
Bae, Dong Han ; Wen, Lan Ying ; Bae, Su Mi ; Kang, Uk ; Kim, Keun Hee ; Jheon, Sanghoon ; Lee, Jeongsang ; Ahn, Woong Shick. / Selenium enhances the efficacy of Radachlorin mediated-photodynamic therapy in cervical cancer model. 12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future. Vol. 7380 2009.
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title = "Selenium enhances the efficacy of Radachlorin mediated-photodynamic therapy in cervical cancer model",
abstract = "Selenium, an essential trace element possessing anti-carcinogenic properties, can induce apoptosis in cancer cells. Our goal was to investigate the enhanced anti-tumor effects of photodynamic therapy (PDT) plus selenium in TC-1 tumor cells implanted into mice. The MTT assay and tumor growth inhibition study were evaluated at various time intervals after the PDT plus a various dose of selenium. Following Radachlorin injections after 3 hr, the mice were then administrated selenium (2ug/kg b.w.) and then, tumors were treated with external light treatment (300 J/cm2). The selenium was administered daily for 20 days. PDT or selenium was found to be more compared to control groups. Moreover, the PDT combined with selenium demonstrated a significant suppression of tumor growth in vitro and in vivo. The tumor growth by the PDT combined with selenium was significantly reduced. These data suggest that selenium plus PDT can induce a significant tumor suppression response compared with PDT alone. Also, it can be an effective approach to induce anti-cancer therapy strategy.",
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Bae, DH, Wen, LY, Bae, SM, Kang, U, Kim, KH, Jheon, S, Lee, J & Ahn, WS 2009, Selenium enhances the efficacy of Radachlorin mediated-photodynamic therapy in cervical cancer model. in 12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future. vol. 7380, 73802T, 12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future, Seattle, WA, United States, 11/06/09. https://doi.org/10.1117/12.824242

Selenium enhances the efficacy of Radachlorin mediated-photodynamic therapy in cervical cancer model. / Bae, Dong Han; Wen, Lan Ying; Bae, Su Mi; Kang, Uk; Kim, Keun Hee; Jheon, Sanghoon; Lee, Jeongsang; Ahn, Woong Shick.

12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future. Vol. 7380 2009. 73802T.

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

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AU - Wen, Lan Ying

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AU - Kang, Uk

AU - Kim, Keun Hee

AU - Jheon, Sanghoon

AU - Lee, Jeongsang

AU - Ahn, Woong Shick

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N2 - Selenium, an essential trace element possessing anti-carcinogenic properties, can induce apoptosis in cancer cells. Our goal was to investigate the enhanced anti-tumor effects of photodynamic therapy (PDT) plus selenium in TC-1 tumor cells implanted into mice. The MTT assay and tumor growth inhibition study were evaluated at various time intervals after the PDT plus a various dose of selenium. Following Radachlorin injections after 3 hr, the mice were then administrated selenium (2ug/kg b.w.) and then, tumors were treated with external light treatment (300 J/cm2). The selenium was administered daily for 20 days. PDT or selenium was found to be more compared to control groups. Moreover, the PDT combined with selenium demonstrated a significant suppression of tumor growth in vitro and in vivo. The tumor growth by the PDT combined with selenium was significantly reduced. These data suggest that selenium plus PDT can induce a significant tumor suppression response compared with PDT alone. Also, it can be an effective approach to induce anti-cancer therapy strategy.

AB - Selenium, an essential trace element possessing anti-carcinogenic properties, can induce apoptosis in cancer cells. Our goal was to investigate the enhanced anti-tumor effects of photodynamic therapy (PDT) plus selenium in TC-1 tumor cells implanted into mice. The MTT assay and tumor growth inhibition study were evaluated at various time intervals after the PDT plus a various dose of selenium. Following Radachlorin injections after 3 hr, the mice were then administrated selenium (2ug/kg b.w.) and then, tumors were treated with external light treatment (300 J/cm2). The selenium was administered daily for 20 days. PDT or selenium was found to be more compared to control groups. Moreover, the PDT combined with selenium demonstrated a significant suppression of tumor growth in vitro and in vivo. The tumor growth by the PDT combined with selenium was significantly reduced. These data suggest that selenium plus PDT can induce a significant tumor suppression response compared with PDT alone. Also, it can be an effective approach to induce anti-cancer therapy strategy.

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Bae DH, Wen LY, Bae SM, Kang U, Kim KH, Jheon S et al. Selenium enhances the efficacy of Radachlorin mediated-photodynamic therapy in cervical cancer model. In 12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future. Vol. 7380. 2009. 73802T https://doi.org/10.1117/12.824242