Safety and Efficacy of Ultrasound-Guided High-Intensity Focused Ultrasound Treatment for Uterine Fibroids and Adenomyosis

Jae Seong Lee, Gi Youn Hong, Kye Hwa Lee, Jung Hwa Song, Tae Eung Kim

Research output: Contribution to journalArticle

Abstract

The objective of this study was to assess the tolerability and efficacy of ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation using a Haifu JC Focused Ultrasound Tumor Therapeutic System (operating transducer frequency: 0.8 MHz, 300–400 W/cm2) under real-time ultrasound guidance (2.5- to 5.0-MHz imaging probe) for uterine fibroids and adenomyosis in 1807 patients (928 with fibroids and 889 with adenomyosis). Volume change and clinical symptom improvement after treatment were evaluated based on symptom severity scores and health-related quality of life scores using the Uterine Fibroid Symptom and Quality of Life questionnaires. At 3, 6 and 12 mo after treatment, symptom severity scores and health-related quality of life scores and reductions in volumes of uterine adenomyosis and fibroids all revealed good effects. The complication rate was 4.6% (84/1807). With supportive care, all complications resolved without any permanent adverse effects. Thus, USgHIFU is an effective, non-invasive modality for treating uterine fibroids and adenomyosis with manageable complications.

Original languageEnglish
Pages (from-to)3214-3221
Number of pages8
JournalUltrasound in Medicine and Biology
Volume45
Issue number12
DOIs
StatePublished - Dec 2019

Fingerprint

Adenomyosis
Leiomyoma
safety
Safety
health
Quality of Life
High-Intensity Focused Ultrasound Ablation
Therapeutics
ablation
transducers
Transducers
tumors
probes
Neoplasms

Keywords

  • Adenomyosis
  • Efficacy
  • High-intensity focused ultrasound ablation
  • Safety
  • Uterine fibroid

Cite this

@article{c67cb43d0f854f74b8540e83d97f3451,
title = "Safety and Efficacy of Ultrasound-Guided High-Intensity Focused Ultrasound Treatment for Uterine Fibroids and Adenomyosis",
abstract = "The objective of this study was to assess the tolerability and efficacy of ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation using a Haifu JC Focused Ultrasound Tumor Therapeutic System (operating transducer frequency: 0.8 MHz, 300–400 W/cm2) under real-time ultrasound guidance (2.5- to 5.0-MHz imaging probe) for uterine fibroids and adenomyosis in 1807 patients (928 with fibroids and 889 with adenomyosis). Volume change and clinical symptom improvement after treatment were evaluated based on symptom severity scores and health-related quality of life scores using the Uterine Fibroid Symptom and Quality of Life questionnaires. At 3, 6 and 12 mo after treatment, symptom severity scores and health-related quality of life scores and reductions in volumes of uterine adenomyosis and fibroids all revealed good effects. The complication rate was 4.6{\%} (84/1807). With supportive care, all complications resolved without any permanent adverse effects. Thus, USgHIFU is an effective, non-invasive modality for treating uterine fibroids and adenomyosis with manageable complications.",
keywords = "Adenomyosis, Efficacy, High-intensity focused ultrasound ablation, Safety, Uterine fibroid",
author = "Lee, {Jae Seong} and Hong, {Gi Youn} and Lee, {Kye Hwa} and Song, {Jung Hwa} and Kim, {Tae Eung}",
year = "2019",
month = "12",
doi = "10.1016/j.ultrasmedbio.2019.08.022",
language = "English",
volume = "45",
pages = "3214--3221",
journal = "Ultrasound in Medicine and Biology",
issn = "0301-5629",
publisher = "Elsevier USA",
number = "12",

}

Safety and Efficacy of Ultrasound-Guided High-Intensity Focused Ultrasound Treatment for Uterine Fibroids and Adenomyosis. / Lee, Jae Seong; Hong, Gi Youn; Lee, Kye Hwa; Song, Jung Hwa; Kim, Tae Eung.

In: Ultrasound in Medicine and Biology, Vol. 45, No. 12, 12.2019, p. 3214-3221.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Safety and Efficacy of Ultrasound-Guided High-Intensity Focused Ultrasound Treatment for Uterine Fibroids and Adenomyosis

AU - Lee, Jae Seong

AU - Hong, Gi Youn

AU - Lee, Kye Hwa

AU - Song, Jung Hwa

AU - Kim, Tae Eung

PY - 2019/12

Y1 - 2019/12

N2 - The objective of this study was to assess the tolerability and efficacy of ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation using a Haifu JC Focused Ultrasound Tumor Therapeutic System (operating transducer frequency: 0.8 MHz, 300–400 W/cm2) under real-time ultrasound guidance (2.5- to 5.0-MHz imaging probe) for uterine fibroids and adenomyosis in 1807 patients (928 with fibroids and 889 with adenomyosis). Volume change and clinical symptom improvement after treatment were evaluated based on symptom severity scores and health-related quality of life scores using the Uterine Fibroid Symptom and Quality of Life questionnaires. At 3, 6 and 12 mo after treatment, symptom severity scores and health-related quality of life scores and reductions in volumes of uterine adenomyosis and fibroids all revealed good effects. The complication rate was 4.6% (84/1807). With supportive care, all complications resolved without any permanent adverse effects. Thus, USgHIFU is an effective, non-invasive modality for treating uterine fibroids and adenomyosis with manageable complications.

AB - The objective of this study was to assess the tolerability and efficacy of ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation using a Haifu JC Focused Ultrasound Tumor Therapeutic System (operating transducer frequency: 0.8 MHz, 300–400 W/cm2) under real-time ultrasound guidance (2.5- to 5.0-MHz imaging probe) for uterine fibroids and adenomyosis in 1807 patients (928 with fibroids and 889 with adenomyosis). Volume change and clinical symptom improvement after treatment were evaluated based on symptom severity scores and health-related quality of life scores using the Uterine Fibroid Symptom and Quality of Life questionnaires. At 3, 6 and 12 mo after treatment, symptom severity scores and health-related quality of life scores and reductions in volumes of uterine adenomyosis and fibroids all revealed good effects. The complication rate was 4.6% (84/1807). With supportive care, all complications resolved without any permanent adverse effects. Thus, USgHIFU is an effective, non-invasive modality for treating uterine fibroids and adenomyosis with manageable complications.

KW - Adenomyosis

KW - Efficacy

KW - High-intensity focused ultrasound ablation

KW - Safety

KW - Uterine fibroid

UR - http://www.scopus.com/inward/record.url?scp=85072594927&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2019.08.022

DO - 10.1016/j.ultrasmedbio.2019.08.022

M3 - Article

C2 - 31563479

AN - SCOPUS:85072594927

VL - 45

SP - 3214

EP - 3221

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

IS - 12

ER -