Role of vacuolating cytotoxin VacA and cytotoxin-associated antigen CagA of Helicobacter pylori in the progression of gastric cancer

Mi Ran Ki, Meeyul Hwang, Ah Young Kim, Eun Mi Lee, Eun Joo Lee, Myeong Mi Lee, Soo Eun Sung, Sang Hyeob Kim, Hye Seung Lee, Kyu Shik Jeong

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Helicobacter (H.) pylori strains that express the cagA and s1a vacA genes are associated with an increased risk for gastric cancer. Here, we examined the association between the products of these virulence genes with the development of gastric cancer by immunohistochemical staining of gastric biopsy specimens taken from 208 routine gastroscopies and 43 gastric cancer patients. The correlation was analyzed by multivariate logistic regression. CagA and VacA expressions in gastric mucosa were significantly associated with chronic gastritis (CG) and intestinal metaplasia (IM), respectively, accompanying CG independent of age. The association of CagA expression with IM accompanying CG was increased in patients over 50-year old (p < 0.01) and that of VacA with CG was significant in patients younger than 50 year (p < 0.05). VacA and CagA were associated with mild IM incidence (p = 0.025 and p = 0.076, respectively) but not advanced IM. In the 43 gastric cancer patients, positivity for VacA was significantly higher in cases of CG and IM than carcinoma (p = 0.042), while that for CagA was slightly higher for individuals with carcinoma than those with CG and IM. These results indicate that CagA and VacA are critical factors for inducing CG and the subsequent progression of IM from CG with an increasing age.

Original languageEnglish
Pages (from-to)23-32
Number of pages10
JournalMolecular and Cellular Biochemistry
Volume396
Issue number1-2
DOIs
StatePublished - 1 Nov 2014

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Cytotoxins
Gastritis
Helicobacter pylori
Metaplasia
Stomach Neoplasms
Genes
Antigens
Biopsy
Logistics
Carcinoma
Gastroscopy
Gastric Mucosa
Virulence
Stomach
Logistic Models
Staining and Labeling
Mucous Membrane
Incidence

Keywords

  • CagA
  • Gastric cancer
  • Helicobacter pylori
  • Precancerous lesion
  • VacA

Cite this

Ki, Mi Ran ; Hwang, Meeyul ; Kim, Ah Young ; Lee, Eun Mi ; Lee, Eun Joo ; Lee, Myeong Mi ; Sung, Soo Eun ; Kim, Sang Hyeob ; Lee, Hye Seung ; Jeong, Kyu Shik. / Role of vacuolating cytotoxin VacA and cytotoxin-associated antigen CagA of Helicobacter pylori in the progression of gastric cancer. In: Molecular and Cellular Biochemistry. 2014 ; Vol. 396, No. 1-2. pp. 23-32.
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Role of vacuolating cytotoxin VacA and cytotoxin-associated antigen CagA of Helicobacter pylori in the progression of gastric cancer. / Ki, Mi Ran; Hwang, Meeyul; Kim, Ah Young; Lee, Eun Mi; Lee, Eun Joo; Lee, Myeong Mi; Sung, Soo Eun; Kim, Sang Hyeob; Lee, Hye Seung; Jeong, Kyu Shik.

In: Molecular and Cellular Biochemistry, Vol. 396, No. 1-2, 01.11.2014, p. 23-32.

Research output: Contribution to journalArticle

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T1 - Role of vacuolating cytotoxin VacA and cytotoxin-associated antigen CagA of Helicobacter pylori in the progression of gastric cancer

AU - Ki, Mi Ran

AU - Hwang, Meeyul

AU - Kim, Ah Young

AU - Lee, Eun Mi

AU - Lee, Eun Joo

AU - Lee, Myeong Mi

AU - Sung, Soo Eun

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AU - Lee, Hye Seung

AU - Jeong, Kyu Shik

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