Role of surgical resection for pulmonary metastasis of hepatocellular carcinoma

Kook Nam Han, Young Tae Kim, Jung Hwan Yoon, Kyung Suk Suh, Ji Yeon Song, Chang Hyun Kang, Sook Whan Sung, Joo Hyun Kim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Introduction: The lung is one of the most important organs affected by metastasis of hepatocellular carcinoma. However, pulmonary metastasectomy for hepatocellular carcinoma has not been well documented. The aim of this study was to evaluate long-term outcome after pulmonary metastasectomy due to metastasis of hepatocellular carcinoma. Methods: Between January 1998 and December 2008, 41 patients underwent pulmonary metastasectomy. Retrospective reviews of medical records and telephone surveys were conducted to identify risk factors of long-term survival. Results: Median time between a complete remission of hepatocellular carcinoma and pulmonary metastasectomy was 11 (4-105) months. During median 25-month follow-up time after metastasectomy, hepatocellular carcinoma recurred in 33 patients. Overall survival rate was 66.9 ± 10% in all 41 patients and disease free survival was 24.5 ± 10% in 24 patients who had no viable hepatocellular carcinoma in the liver preoperatively. An analysis of recurrence revealed that survival was better in patients whose recurrence was limited to either in the liver or lungs compared to that in patients whose recurrence took place in the distant organ other than the liver or lungs (extrahepatic/extrapulmonary metastasis) (p=0.004, log-rank). Conclusions: Pulmonary metastasectomy for hepatocellular carcinoma can be performed safely without major morbidity. Recurrence at organs other than the liver or lung was found to result in poor survival, which suggests that a careful search for distant metastasis at other locations is mandatory for patient selection. This study demonstrated that pulmonary metastasectomy can play an important role in selected patients with pulmonary metastasis of hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalLung Cancer
Volume70
Issue number3
DOIs
StatePublished - 1 Dec 2010

Fingerprint

Metastasectomy
Hepatocellular Carcinoma
Neoplasm Metastasis
Lung
Recurrence
Liver
Survival
Telephone
Patient Selection
Disease-Free Survival
Medical Records
Survival Rate
Morbidity

Keywords

  • Hepatocellular carcinoma
  • Liver, Metastasis
  • Lung Neoplasms
  • Metastasectomy
  • Recurrence

Cite this

Han, Kook Nam ; Kim, Young Tae ; Yoon, Jung Hwan ; Suh, Kyung Suk ; Song, Ji Yeon ; Kang, Chang Hyun ; Sung, Sook Whan ; Kim, Joo Hyun. / Role of surgical resection for pulmonary metastasis of hepatocellular carcinoma. In: Lung Cancer. 2010 ; Vol. 70, No. 3. pp. 295-300.
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abstract = "Introduction: The lung is one of the most important organs affected by metastasis of hepatocellular carcinoma. However, pulmonary metastasectomy for hepatocellular carcinoma has not been well documented. The aim of this study was to evaluate long-term outcome after pulmonary metastasectomy due to metastasis of hepatocellular carcinoma. Methods: Between January 1998 and December 2008, 41 patients underwent pulmonary metastasectomy. Retrospective reviews of medical records and telephone surveys were conducted to identify risk factors of long-term survival. Results: Median time between a complete remission of hepatocellular carcinoma and pulmonary metastasectomy was 11 (4-105) months. During median 25-month follow-up time after metastasectomy, hepatocellular carcinoma recurred in 33 patients. Overall survival rate was 66.9 ± 10{\%} in all 41 patients and disease free survival was 24.5 ± 10{\%} in 24 patients who had no viable hepatocellular carcinoma in the liver preoperatively. An analysis of recurrence revealed that survival was better in patients whose recurrence was limited to either in the liver or lungs compared to that in patients whose recurrence took place in the distant organ other than the liver or lungs (extrahepatic/extrapulmonary metastasis) (p=0.004, log-rank). Conclusions: Pulmonary metastasectomy for hepatocellular carcinoma can be performed safely without major morbidity. Recurrence at organs other than the liver or lung was found to result in poor survival, which suggests that a careful search for distant metastasis at other locations is mandatory for patient selection. This study demonstrated that pulmonary metastasectomy can play an important role in selected patients with pulmonary metastasis of hepatocellular carcinoma.",
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Role of surgical resection for pulmonary metastasis of hepatocellular carcinoma. / Han, Kook Nam; Kim, Young Tae; Yoon, Jung Hwan; Suh, Kyung Suk; Song, Ji Yeon; Kang, Chang Hyun; Sung, Sook Whan; Kim, Joo Hyun.

In: Lung Cancer, Vol. 70, No. 3, 01.12.2010, p. 295-300.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Role of surgical resection for pulmonary metastasis of hepatocellular carcinoma

AU - Han, Kook Nam

AU - Kim, Young Tae

AU - Yoon, Jung Hwan

AU - Suh, Kyung Suk

AU - Song, Ji Yeon

AU - Kang, Chang Hyun

AU - Sung, Sook Whan

AU - Kim, Joo Hyun

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N2 - Introduction: The lung is one of the most important organs affected by metastasis of hepatocellular carcinoma. However, pulmonary metastasectomy for hepatocellular carcinoma has not been well documented. The aim of this study was to evaluate long-term outcome after pulmonary metastasectomy due to metastasis of hepatocellular carcinoma. Methods: Between January 1998 and December 2008, 41 patients underwent pulmonary metastasectomy. Retrospective reviews of medical records and telephone surveys were conducted to identify risk factors of long-term survival. Results: Median time between a complete remission of hepatocellular carcinoma and pulmonary metastasectomy was 11 (4-105) months. During median 25-month follow-up time after metastasectomy, hepatocellular carcinoma recurred in 33 patients. Overall survival rate was 66.9 ± 10% in all 41 patients and disease free survival was 24.5 ± 10% in 24 patients who had no viable hepatocellular carcinoma in the liver preoperatively. An analysis of recurrence revealed that survival was better in patients whose recurrence was limited to either in the liver or lungs compared to that in patients whose recurrence took place in the distant organ other than the liver or lungs (extrahepatic/extrapulmonary metastasis) (p=0.004, log-rank). Conclusions: Pulmonary metastasectomy for hepatocellular carcinoma can be performed safely without major morbidity. Recurrence at organs other than the liver or lung was found to result in poor survival, which suggests that a careful search for distant metastasis at other locations is mandatory for patient selection. This study demonstrated that pulmonary metastasectomy can play an important role in selected patients with pulmonary metastasis of hepatocellular carcinoma.

AB - Introduction: The lung is one of the most important organs affected by metastasis of hepatocellular carcinoma. However, pulmonary metastasectomy for hepatocellular carcinoma has not been well documented. The aim of this study was to evaluate long-term outcome after pulmonary metastasectomy due to metastasis of hepatocellular carcinoma. Methods: Between January 1998 and December 2008, 41 patients underwent pulmonary metastasectomy. Retrospective reviews of medical records and telephone surveys were conducted to identify risk factors of long-term survival. Results: Median time between a complete remission of hepatocellular carcinoma and pulmonary metastasectomy was 11 (4-105) months. During median 25-month follow-up time after metastasectomy, hepatocellular carcinoma recurred in 33 patients. Overall survival rate was 66.9 ± 10% in all 41 patients and disease free survival was 24.5 ± 10% in 24 patients who had no viable hepatocellular carcinoma in the liver preoperatively. An analysis of recurrence revealed that survival was better in patients whose recurrence was limited to either in the liver or lungs compared to that in patients whose recurrence took place in the distant organ other than the liver or lungs (extrahepatic/extrapulmonary metastasis) (p=0.004, log-rank). Conclusions: Pulmonary metastasectomy for hepatocellular carcinoma can be performed safely without major morbidity. Recurrence at organs other than the liver or lung was found to result in poor survival, which suggests that a careful search for distant metastasis at other locations is mandatory for patient selection. This study demonstrated that pulmonary metastasectomy can play an important role in selected patients with pulmonary metastasis of hepatocellular carcinoma.

KW - Hepatocellular carcinoma

KW - Liver, Metastasis

KW - Lung Neoplasms

KW - Metastasectomy

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JF - Lung Cancer

SN - 0169-5002

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