Risk of Subsequent Events in Patients With Minor Ischemic Stroke or High-Risk Transient Ischemic Attack

Keon Joo Lee; Dong Woo Shin; Hong Kyun Park; Beom Joon Kim; Jong Moo Park; Kyusik Kang; Tai Hwan Park; Kyung Bok Lee; Keun Sik Hong; Yong Jin Cho; Dong Eog Kim; Wi Sun Ryu; Byung Chul Lee; Kyung Ho Yu; Mi Sun Oh; Soo Joo Lee; Jae Guk Kim; Jun Lee; Jae Kwan Cha; Dae Hyun Kim; Joon Tae Kim; Kang Ho Choi; Jay Chol Choi; Eva Lesén; Jonatan Hedberg; Amarjeet Tank; Edmond G. Fita; Ji Eun Song; Ji Sung Lee; Juneyoung Lee; Hee Joon Bae

doi:10.3346/jkms.2022.37.e254

Risk of Subsequent Events in Patients With Minor Ischemic Stroke or High-Risk Transient Ischemic Attack

Keon Joo Lee, Dong Woo Shin, Hong Kyun Park, Beom Joon Kim, Jong Moo Park, Kyusik Kang, Tai Hwan Park, Kyung Bok Lee, Keun Sik Hong, Yong Jin Cho, Dong Eog Kim, Wi Sun Ryu, Byung Chul Lee, Kyung Ho Yu, Mi Sun Oh, Soo Joo Lee, Jae Guk Kim, Jun Lee, Jae Kwan Cha, Dae Hyun KimJoon Tae Kim, Kang Ho Choi, Jay Chol Choi, Eva Lesén, Jonatan Hedberg, Amarjeet Tank, Edmond G. Fita, Ji Eun Song, Ji Sung Lee, Juneyoung Lee, Hee Joon Bae

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

This study aimed to present the prognosis after minor acute ischemic stroke (AIS) or transient ischemic attack (TIA), using a definition of subsequent stroke in accordance with recent clinical trials. In total, 9,506 patients with minor AIS (National Institutes of Health Stroke Scale ≤ 5) or high-risk TIA (acute lesions or ≥ 50% cerebral artery steno-occlusion) admitted between November 2010 and October 2013 were included. The primary outcome was the composite of stroke (progression of initial event or a subsequent event) and all-cause mortality. The cumulative incidence of stroke or death was 11.2% at 1 month, 13.3% at 3 months and 16.7% at 1 year. Incidence rate of stroke or death in the first month was 12.5 per 100 person-months: highest in patients with large artery atherosclerosis (17.0). The risk of subsequent events shortly after a minor AIS or high-risk TIA was substantial, particularly in patients with large artery atherosclerosis.

Original language	English
Article number	e254
Journal	Journal of Korean Medical Science
Volume	37
Issue number	33
DOIs	https://doi.org/10.3346/jkms.2022.37.e254
State	Published - 2022

Bibliographical note

Publisher Copyright:
© 2022. The Korean Academy of Medical Sciences.

Keywords

Event outcome
Ischemic attack
Minor ischemic stroke
Stroke recurrence
Transient

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10.3346/jkms.2022.37.e254

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Lee, K. J., Shin, D. W., Park, H. K., Kim, B. J., Park, J. M., Kang, K., Park, T. H., Lee, K. B., Hong, K. S., Cho, Y. J., Kim, D. E., Ryu, W. S., Lee, B. C., Yu, K. H., Oh, M. S., Lee, S. J., Kim, J. G., Lee, J., Cha, J. K., ... Bae, H. J. (2022). Risk of Subsequent Events in Patients With Minor Ischemic Stroke or High-Risk Transient Ischemic Attack. Journal of Korean Medical Science, 37(33), Article e254. https://doi.org/10.3346/jkms.2022.37.e254

@article{9791dc22a15045dcb023cbb7934058a2,

title = "Risk of Subsequent Events in Patients With Minor Ischemic Stroke or High-Risk Transient Ischemic Attack",

abstract = "This study aimed to present the prognosis after minor acute ischemic stroke (AIS) or transient ischemic attack (TIA), using a definition of subsequent stroke in accordance with recent clinical trials. In total, 9,506 patients with minor AIS (National Institutes of Health Stroke Scale ≤ 5) or high-risk TIA (acute lesions or ≥ 50% cerebral artery steno-occlusion) admitted between November 2010 and October 2013 were included. The primary outcome was the composite of stroke (progression of initial event or a subsequent event) and all-cause mortality. The cumulative incidence of stroke or death was 11.2% at 1 month, 13.3% at 3 months and 16.7% at 1 year. Incidence rate of stroke or death in the first month was 12.5 per 100 person-months: highest in patients with large artery atherosclerosis (17.0). The risk of subsequent events shortly after a minor AIS or high-risk TIA was substantial, particularly in patients with large artery atherosclerosis.",

keywords = "Event outcome, Ischemic attack, Minor ischemic stroke, Stroke recurrence, Transient",

author = "Lee, {Keon Joo} and Shin, {Dong Woo} and Park, {Hong Kyun} and Kim, {Beom Joon} and Park, {Jong Moo} and Kyusik Kang and Park, {Tai Hwan} and Lee, {Kyung Bok} and Hong, {Keun Sik} and Cho, {Yong Jin} and Kim, {Dong Eog} and Ryu, {Wi Sun} and Lee, {Byung Chul} and Yu, {Kyung Ho} and Oh, {Mi Sun} and Lee, {Soo Joo} and Kim, {Jae Guk} and Jun Lee and Cha, {Jae Kwan} and Kim, {Dae Hyun} and Kim, {Joon Tae} and Choi, {Kang Ho} and Choi, {Jay Chol} and Eva Les{\'e}n and Jonatan Hedberg and Amarjeet Tank and Fita, {Edmond G.} and Song, {Ji Eun} and Lee, {Ji Sung} and Juneyoung Lee and Bae, {Hee Joon}",

note = "Publisher Copyright: {\textcopyright} 2022. The Korean Academy of Medical Sciences.",

year = "2022",

doi = "10.3346/jkms.2022.37.e254",

language = "English",

volume = "37",

journal = "Journal of Korean Medical Science",

issn = "1011-8934",

publisher = "Korean Academy of Medical Science",

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Lee, KJ, Shin, DW, Park, HK, Kim, BJ, Park, JM, Kang, K, Park, TH, Lee, KB, Hong, KS, Cho, YJ, Kim, DE, Ryu, WS, Lee, BC, Yu, KH, Oh, MS, Lee, SJ, Kim, JG, Lee, J, Cha, JK, Kim, DH, Kim, JT, Choi, KH, Choi, JC, Lesén, E, Hedberg, J, Tank, A, Fita, EG, Song, JE, Lee, JS, Lee, J & Bae, HJ 2022, 'Risk of Subsequent Events in Patients With Minor Ischemic Stroke or High-Risk Transient Ischemic Attack', Journal of Korean Medical Science, vol. 37, no. 33, e254. https://doi.org/10.3346/jkms.2022.37.e254

TY - JOUR

T1 - Risk of Subsequent Events in Patients With Minor Ischemic Stroke or High-Risk Transient Ischemic Attack

AU - Lee, Keon Joo

AU - Shin, Dong Woo

AU - Park, Hong Kyun

AU - Kim, Beom Joon

AU - Park, Jong Moo

AU - Kang, Kyusik

AU - Park, Tai Hwan

AU - Lee, Kyung Bok

AU - Hong, Keun Sik

AU - Cho, Yong Jin

AU - Kim, Dong Eog

AU - Ryu, Wi Sun

AU - Lee, Byung Chul

AU - Yu, Kyung Ho

AU - Oh, Mi Sun

AU - Lee, Soo Joo

AU - Kim, Jae Guk

AU - Lee, Jun

AU - Cha, Jae Kwan

AU - Kim, Dae Hyun

AU - Kim, Joon Tae

AU - Choi, Kang Ho

AU - Choi, Jay Chol

AU - Lesén, Eva

AU - Hedberg, Jonatan

AU - Tank, Amarjeet

AU - Fita, Edmond G.

AU - Song, Ji Eun

AU - Lee, Ji Sung

AU - Lee, Juneyoung

AU - Bae, Hee Joon

PY - 2022

Y1 - 2022

N2 - This study aimed to present the prognosis after minor acute ischemic stroke (AIS) or transient ischemic attack (TIA), using a definition of subsequent stroke in accordance with recent clinical trials. In total, 9,506 patients with minor AIS (National Institutes of Health Stroke Scale ≤ 5) or high-risk TIA (acute lesions or ≥ 50% cerebral artery steno-occlusion) admitted between November 2010 and October 2013 were included. The primary outcome was the composite of stroke (progression of initial event or a subsequent event) and all-cause mortality. The cumulative incidence of stroke or death was 11.2% at 1 month, 13.3% at 3 months and 16.7% at 1 year. Incidence rate of stroke or death in the first month was 12.5 per 100 person-months: highest in patients with large artery atherosclerosis (17.0). The risk of subsequent events shortly after a minor AIS or high-risk TIA was substantial, particularly in patients with large artery atherosclerosis.

AB - This study aimed to present the prognosis after minor acute ischemic stroke (AIS) or transient ischemic attack (TIA), using a definition of subsequent stroke in accordance with recent clinical trials. In total, 9,506 patients with minor AIS (National Institutes of Health Stroke Scale ≤ 5) or high-risk TIA (acute lesions or ≥ 50% cerebral artery steno-occlusion) admitted between November 2010 and October 2013 were included. The primary outcome was the composite of stroke (progression of initial event or a subsequent event) and all-cause mortality. The cumulative incidence of stroke or death was 11.2% at 1 month, 13.3% at 3 months and 16.7% at 1 year. Incidence rate of stroke or death in the first month was 12.5 per 100 person-months: highest in patients with large artery atherosclerosis (17.0). The risk of subsequent events shortly after a minor AIS or high-risk TIA was substantial, particularly in patients with large artery atherosclerosis.

KW - Event outcome

KW - Ischemic attack

KW - Minor ischemic stroke

KW - Stroke recurrence

KW - Transient

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U2 - 10.3346/jkms.2022.37.e254

DO - 10.3346/jkms.2022.37.e254

M3 - Article

C2 - 35996931

AN - SCOPUS:85136198129

SN - 1011-8934

VL - 37

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

IS - 33

M1 - e254

ER -

Risk of Subsequent Events in Patients With Minor Ischemic Stroke or High-Risk Transient Ischemic Attack

Abstract

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Keywords

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