Risk of Atrial Fibrillation in Relation to the Time Course of Type 2 Diabetes Mellitus and Fasting Blood Glucose

Seokhun Yang, Eue Keun Choi, Kyung Do Han, Soonil Kwon, Seo Young Lee, Jiesuck Park, You jung Choi, Hyun Jung Lee, Inki Moon, Euijae Lee, So Ryoung Lee, Myung Jin Cha, Woo Hyun Lim, Seil Oh

Research output: Contribution to journalArticle

Abstract

The relation of progression of type 2 diabetes and detailed fasting glucose level with risk of atrial fibrillation (AF) is not well known. A total of 6,199,629 subjects not diagnosed with AF who underwent health check-up in 2009 were included from the Korean National Health Insurance Service database. Risk of AF was compared among subjects with normal fasting glucose (NFG), subjects with impaired fasting glucose (IFG), patients with diabetes duration <5 years (early diabetes mellitus [DM]), and patients with diabetes duration ≥5 years (late DM). Next, risk of AF stratified by fasting glucose level per 10 mg/dL was assessed. During a mean follow-up of 7.2 years, the risk of AF significantly increased across the time course of type 2 diabetes (adjusted hazard ratio (aHR) 1.04, 95% confidence interval (CI) 1.02 to 1.05 for IFG; aHR 1.06, 95% CI 1.04 to 1.08 for early DM; aHR 1.09, 95% CI 1.07 to 1.11 for late DM). The risk of AF was significantly higher in subjects who progressed to type 2 diabetes in the IFG group. Risk of AF increased with a 10 mg/dL increment of fasting blood glucose (p-for-trend <0.0001). However, there was a U-shape relationship between fasting blood glucose and risk of AF in those who received antidiabetic medication. In conclusion, the risk of AF increased with the time course of type 2 diabetes. However, low blood glucose in antidiabetic medication user was associated with an increased risk of AF.

Original languageEnglish
Pages (from-to)1881-1888
Number of pages8
JournalAmerican Journal of Cardiology
Volume124
Issue number12
DOIs
StatePublished - 15 Dec 2019

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Atrial Fibrillation
Type 2 Diabetes Mellitus
Blood Glucose
Fasting
Glucose
Diabetes Mellitus
National Health Programs
Confidence Intervals
Hypoglycemic Agents
Databases
Health

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Yang, Seokhun ; Choi, Eue Keun ; Han, Kyung Do ; Kwon, Soonil ; Lee, Seo Young ; Park, Jiesuck ; Choi, You jung ; Lee, Hyun Jung ; Moon, Inki ; Lee, Euijae ; Lee, So Ryoung ; Cha, Myung Jin ; Lim, Woo Hyun ; Oh, Seil. / Risk of Atrial Fibrillation in Relation to the Time Course of Type 2 Diabetes Mellitus and Fasting Blood Glucose. In: American Journal of Cardiology. 2019 ; Vol. 124, No. 12. pp. 1881-1888.
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abstract = "The relation of progression of type 2 diabetes and detailed fasting glucose level with risk of atrial fibrillation (AF) is not well known. A total of 6,199,629 subjects not diagnosed with AF who underwent health check-up in 2009 were included from the Korean National Health Insurance Service database. Risk of AF was compared among subjects with normal fasting glucose (NFG), subjects with impaired fasting glucose (IFG), patients with diabetes duration <5 years (early diabetes mellitus [DM]), and patients with diabetes duration ≥5 years (late DM). Next, risk of AF stratified by fasting glucose level per 10 mg/dL was assessed. During a mean follow-up of 7.2 years, the risk of AF significantly increased across the time course of type 2 diabetes (adjusted hazard ratio (aHR) 1.04, 95{\%} confidence interval (CI) 1.02 to 1.05 for IFG; aHR 1.06, 95{\%} CI 1.04 to 1.08 for early DM; aHR 1.09, 95{\%} CI 1.07 to 1.11 for late DM). The risk of AF was significantly higher in subjects who progressed to type 2 diabetes in the IFG group. Risk of AF increased with a 10 mg/dL increment of fasting blood glucose (p-for-trend <0.0001). However, there was a U-shape relationship between fasting blood glucose and risk of AF in those who received antidiabetic medication. In conclusion, the risk of AF increased with the time course of type 2 diabetes. However, low blood glucose in antidiabetic medication user was associated with an increased risk of AF.",
author = "Seokhun Yang and Choi, {Eue Keun} and Han, {Kyung Do} and Soonil Kwon and Lee, {Seo Young} and Jiesuck Park and Choi, {You jung} and Lee, {Hyun Jung} and Inki Moon and Euijae Lee and Lee, {So Ryoung} and Cha, {Myung Jin} and Lim, {Woo Hyun} and Seil Oh",
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Yang, S, Choi, EK, Han, KD, Kwon, S, Lee, SY, Park, J, Choi, YJ, Lee, HJ, Moon, I, Lee, E, Lee, SR, Cha, MJ, Lim, WH & Oh, S 2019, 'Risk of Atrial Fibrillation in Relation to the Time Course of Type 2 Diabetes Mellitus and Fasting Blood Glucose', American Journal of Cardiology, vol. 124, no. 12, pp. 1881-1888. https://doi.org/10.1016/j.amjcard.2019.09.009

Risk of Atrial Fibrillation in Relation to the Time Course of Type 2 Diabetes Mellitus and Fasting Blood Glucose. / Yang, Seokhun; Choi, Eue Keun; Han, Kyung Do; Kwon, Soonil; Lee, Seo Young; Park, Jiesuck; Choi, You jung; Lee, Hyun Jung; Moon, Inki; Lee, Euijae; Lee, So Ryoung; Cha, Myung Jin; Lim, Woo Hyun; Oh, Seil.

In: American Journal of Cardiology, Vol. 124, No. 12, 15.12.2019, p. 1881-1888.

Research output: Contribution to journalArticle

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T1 - Risk of Atrial Fibrillation in Relation to the Time Course of Type 2 Diabetes Mellitus and Fasting Blood Glucose

AU - Yang, Seokhun

AU - Choi, Eue Keun

AU - Han, Kyung Do

AU - Kwon, Soonil

AU - Lee, Seo Young

AU - Park, Jiesuck

AU - Choi, You jung

AU - Lee, Hyun Jung

AU - Moon, Inki

AU - Lee, Euijae

AU - Lee, So Ryoung

AU - Cha, Myung Jin

AU - Lim, Woo Hyun

AU - Oh, Seil

PY - 2019/12/15

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