Risk factors associated with adverse events during endoscopic ultrasound-guided tissue sampling

Kwang Hyuck Lee, Eun Young Kim, Juhee Cho, Danbee Kang, Seungmin Bang, Hyung Kil Kim, Gwang Ha Kim, Hyun Jong Choi, Joung Ho Han, Seong Woo Jeon, Ji Kon Ryu, Jeong Seop Moon, Tae Hee Lee, Jin Woong Cho, Tae Hyeon Kim, Young Koog Cheon, Chang Hwan Park, Jong Kyun Lee, Jong Ho Moon, Chang Min Cho

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Abstract

Background and aim Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is commonly used to obtain tissue external to the gastrointestinal tract. EUS-FNA is relatively safe, but occasionally adverse events have been reported. There is scarcity of data on risk factors of adverse events. The aim of this study is to identify risk factors associated with EUS-FNA. Methods In this multicenter case-control study, we retrospectively reviewed 4,097 cases between 2009 and 2012 at 15 hospitals in Korea. Among the patients there were 104 cases (2.5%) who had adverse events of which 12 (0.29%) were severe. We matched 520 controls (1:5 ratios) stratified by hospital to analyze the potential risk factors. Results The most common adverse events were pancreatitis (45/104, 43.3%) and infection (46/104, 44.2%). Endoscopic retrograde cholangiopancreatography (ERCP) on the same day was a risk factor of all adverse events [OR = 2.41, 95% CI (1.41, 4.12)], pancreatitis [OR = 2.31, 95% CI (1.02, 5.25)], and infection [OR = 2.75, 95% CI (1.31, 5.78)]. More than 15 to-and-fro movements during puncture increased the risk of pancreatitis [OR = 2.30, 95% CI (1.11, 4.77)] and infection [OR = 3.65, 95% CI (1.55, 8.59)]. A higher number of punctures was positively correlated with pancreatitis [OR = 1.34, 95% CI (1.08, 1.67)] but negatively correlated with infection [OR = 0.66, 95% CI (0.48, 0.89)]. Conclusions EUS-FNA is a safe procedure in which serious adverse events are rare. We define some risk factors of adverse events during EUS-FNA, including ERCP on the same day, a higher number of punctures, and more than 15 to-and-fro movements.

Original languageEnglish
Article numbere0189347
JournalPLoS ONE
Volume12
Issue number12
DOIs
StatePublished - Dec 2017

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Lee, K. H., Kim, E. Y., Cho, J., Kang, D., Bang, S., Kim, H. K., Kim, G. H., Choi, H. J., Han, J. H., Jeon, S. W., Ryu, J. K., Moon, J. S., Lee, T. H., Cho, J. W., Kim, T. H., Cheon, Y. K., Park, C. H., Lee, J. K., Moon, J. H., & Cho, C. M. (2017). Risk factors associated with adverse events during endoscopic ultrasound-guided tissue sampling. PLoS ONE, 12(12), [e0189347]. https://doi.org/10.1371/journal.pone.0189347