Right-left ventricular balance in implanted electrically powered artificial hearts

J. W. Long, P. Khanwilkar, K. R. Crump, G. M. Pantalos, M. Kinoshita, Hee Chan Kim, D. B. Olsen

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

An electrohydraulic total artificial heart (EHTAH), using an interatrial shunt (IAS) for right-left heart balance, was evaluated in acute, in vivo, open-chested calves. The EHTAH system demonstrated physiologic autoregulation with Starling-like responsiveness to preload. Output varied from 4 to 9 L/min, as right atrial pressure increased from 3 to 15 mmHg. Device output was minimally influenced by afterload. The efficacy of an IAS to balance the EHTAH was demonstrated over a wide range of preload and afterload conditions. Interatrial shunt flow rates, reflective of the degree of right-left imbalance, varied from 2% to 14% (IAS flow from left to right) of cardiac output. Left atrial pressures typically did not exceed right atrial pressures by more than 6-8 mmHg using an instrumented vascular graft such as the IAS. The simplicity and distinct anatomic, surgical, and engineering advantages of the IAS approach to right-left balance of implanted electrically powered artificial hearts justify further development toward a reliable long-term design.

Original languageEnglish
JournalASAIO Transactions
Volume36
Issue number3
StatePublished - 1 Jul 1990

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Artificial Heart
Atrial Pressure
Starlings
Cardiac Output
Blood Vessels
Homeostasis
Thorax
Transplants
Equipment and Supplies

Cite this

Long, J. W., Khanwilkar, P., Crump, K. R., Pantalos, G. M., Kinoshita, M., Kim, H. C., & Olsen, D. B. (1990). Right-left ventricular balance in implanted electrically powered artificial hearts. ASAIO Transactions, 36(3).
Long, J. W. ; Khanwilkar, P. ; Crump, K. R. ; Pantalos, G. M. ; Kinoshita, M. ; Kim, Hee Chan ; Olsen, D. B. / Right-left ventricular balance in implanted electrically powered artificial hearts. In: ASAIO Transactions. 1990 ; Vol. 36, No. 3.
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abstract = "An electrohydraulic total artificial heart (EHTAH), using an interatrial shunt (IAS) for right-left heart balance, was evaluated in acute, in vivo, open-chested calves. The EHTAH system demonstrated physiologic autoregulation with Starling-like responsiveness to preload. Output varied from 4 to 9 L/min, as right atrial pressure increased from 3 to 15 mmHg. Device output was minimally influenced by afterload. The efficacy of an IAS to balance the EHTAH was demonstrated over a wide range of preload and afterload conditions. Interatrial shunt flow rates, reflective of the degree of right-left imbalance, varied from 2{\%} to 14{\%} (IAS flow from left to right) of cardiac output. Left atrial pressures typically did not exceed right atrial pressures by more than 6-8 mmHg using an instrumented vascular graft such as the IAS. The simplicity and distinct anatomic, surgical, and engineering advantages of the IAS approach to right-left balance of implanted electrically powered artificial hearts justify further development toward a reliable long-term design.",
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Long, JW, Khanwilkar, P, Crump, KR, Pantalos, GM, Kinoshita, M, Kim, HC & Olsen, DB 1990, 'Right-left ventricular balance in implanted electrically powered artificial hearts', ASAIO Transactions, vol. 36, no. 3.

Right-left ventricular balance in implanted electrically powered artificial hearts. / Long, J. W.; Khanwilkar, P.; Crump, K. R.; Pantalos, G. M.; Kinoshita, M.; Kim, Hee Chan; Olsen, D. B.

In: ASAIO Transactions, Vol. 36, No. 3, 01.07.1990.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Right-left ventricular balance in implanted electrically powered artificial hearts

AU - Long, J. W.

AU - Khanwilkar, P.

AU - Crump, K. R.

AU - Pantalos, G. M.

AU - Kinoshita, M.

AU - Kim, Hee Chan

AU - Olsen, D. B.

PY - 1990/7/1

Y1 - 1990/7/1

N2 - An electrohydraulic total artificial heart (EHTAH), using an interatrial shunt (IAS) for right-left heart balance, was evaluated in acute, in vivo, open-chested calves. The EHTAH system demonstrated physiologic autoregulation with Starling-like responsiveness to preload. Output varied from 4 to 9 L/min, as right atrial pressure increased from 3 to 15 mmHg. Device output was minimally influenced by afterload. The efficacy of an IAS to balance the EHTAH was demonstrated over a wide range of preload and afterload conditions. Interatrial shunt flow rates, reflective of the degree of right-left imbalance, varied from 2% to 14% (IAS flow from left to right) of cardiac output. Left atrial pressures typically did not exceed right atrial pressures by more than 6-8 mmHg using an instrumented vascular graft such as the IAS. The simplicity and distinct anatomic, surgical, and engineering advantages of the IAS approach to right-left balance of implanted electrically powered artificial hearts justify further development toward a reliable long-term design.

AB - An electrohydraulic total artificial heart (EHTAH), using an interatrial shunt (IAS) for right-left heart balance, was evaluated in acute, in vivo, open-chested calves. The EHTAH system demonstrated physiologic autoregulation with Starling-like responsiveness to preload. Output varied from 4 to 9 L/min, as right atrial pressure increased from 3 to 15 mmHg. Device output was minimally influenced by afterload. The efficacy of an IAS to balance the EHTAH was demonstrated over a wide range of preload and afterload conditions. Interatrial shunt flow rates, reflective of the degree of right-left imbalance, varied from 2% to 14% (IAS flow from left to right) of cardiac output. Left atrial pressures typically did not exceed right atrial pressures by more than 6-8 mmHg using an instrumented vascular graft such as the IAS. The simplicity and distinct anatomic, surgical, and engineering advantages of the IAS approach to right-left balance of implanted electrically powered artificial hearts justify further development toward a reliable long-term design.

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Long JW, Khanwilkar P, Crump KR, Pantalos GM, Kinoshita M, Kim HC et al. Right-left ventricular balance in implanted electrically powered artificial hearts. ASAIO Transactions. 1990 Jul 1;36(3).