Retinol binding protein-4 elevation is associated with serum thyroid-stimulating hormone level independently of obesity in elderly subjects with normal glucose tolerance

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Abstract

Context: Elevated levels of retinol binding protein-4 (RBP4) are positively correlated with insulin resistance, obesity, diabetes mellitus, and cardiovascular disease (CVD). Subclinical hypothyroidism (SCH) has also been associated with CVD; however, the factors linking SCH to CVD are not clear. Objective: The objective of the study was to evaluate risk factors for CVD in elderly patients grouped according to thyroid function. Design: 217 subjects (≥65 yr old) were randomly selected from a population and allocated to a euthyroid group (n = 177) and an SCH group (n = 40) on the basis of plasma concentrations of TSH and free T4. We included subjects with normal glucose tolerance by a 75-g oral glucose tolerance test and subjects with impaired fasting glucose. We measured anthropometric parameters, levels of fasting glucose and insulin, hemoglobin A1c, adiponectin, RBP4, lipid profiles, total body fat content, and the area of sc and visceral fat. Results: The SCH group had higher RBP4 levels than the euthyroid group, irrespective of body mass index and fat content. Subcutaneous and visceral fat areas and total body fat percentage did not differ between groups and were not correlated with RBP4 level. Other CVD risk factors did not differ between groups. RBP4 level was positively correlated with TSH level (r = 0.241, P = 0.001) after adjustment for age, sex, and body mass index. Conclusions: Plasma RBP4 levels were associated with SCH independent of obesity in elderly subjects with normal glucose tolerance, indicating that RBP4 level could be used as an index of CVD risk in SCH.

Original languageEnglish
Pages (from-to)2313-2318
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume93
Issue number6
DOIs
StatePublished - Jun 2008

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Retinol-Binding Proteins
Thyrotropin
Hypothyroidism
Cardiovascular Diseases
Obesity
Glucose
Fats
Serum
Intra-Abdominal Fat
Adipose Tissue
Fasting
Plasma Retinol-Binding Proteins
Body Mass Index
Insulin
Subcutaneous Fat
Adiponectin
Glucose Tolerance Test
Medical problems
Insulin Resistance
Diabetes Mellitus

Cite this

@article{06b53ad760864db1a27a27d0c9ff9e90,
title = "Retinol binding protein-4 elevation is associated with serum thyroid-stimulating hormone level independently of obesity in elderly subjects with normal glucose tolerance",
abstract = "Context: Elevated levels of retinol binding protein-4 (RBP4) are positively correlated with insulin resistance, obesity, diabetes mellitus, and cardiovascular disease (CVD). Subclinical hypothyroidism (SCH) has also been associated with CVD; however, the factors linking SCH to CVD are not clear. Objective: The objective of the study was to evaluate risk factors for CVD in elderly patients grouped according to thyroid function. Design: 217 subjects (≥65 yr old) were randomly selected from a population and allocated to a euthyroid group (n = 177) and an SCH group (n = 40) on the basis of plasma concentrations of TSH and free T4. We included subjects with normal glucose tolerance by a 75-g oral glucose tolerance test and subjects with impaired fasting glucose. We measured anthropometric parameters, levels of fasting glucose and insulin, hemoglobin A1c, adiponectin, RBP4, lipid profiles, total body fat content, and the area of sc and visceral fat. Results: The SCH group had higher RBP4 levels than the euthyroid group, irrespective of body mass index and fat content. Subcutaneous and visceral fat areas and total body fat percentage did not differ between groups and were not correlated with RBP4 level. Other CVD risk factors did not differ between groups. RBP4 level was positively correlated with TSH level (r = 0.241, P = 0.001) after adjustment for age, sex, and body mass index. Conclusions: Plasma RBP4 levels were associated with SCH independent of obesity in elderly subjects with normal glucose tolerance, indicating that RBP4 level could be used as an index of CVD risk in SCH.",
author = "Sung, {Hee Choi} and You, {Jin Lee} and Young, {Joo Park} and Ki, {Woong Kim} and Eun, {Jung Lee} and Soo Lim and Do, {Joon Park} and Sang, {Eun Kim} and Kyong, {Soo Park} and Jang, {Hak C.} and Bo, {Youn Cho}",
year = "2008",
month = "6",
doi = "10.1210/jc.2007-2536",
language = "English",
volume = "93",
pages = "2313--2318",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Retinol binding protein-4 elevation is associated with serum thyroid-stimulating hormone level independently of obesity in elderly subjects with normal glucose tolerance

AU - Sung, Hee Choi

AU - You, Jin Lee

AU - Young, Joo Park

AU - Ki, Woong Kim

AU - Eun, Jung Lee

AU - Lim, Soo

AU - Do, Joon Park

AU - Sang, Eun Kim

AU - Kyong, Soo Park

AU - Jang, Hak C.

AU - Bo, Youn Cho

PY - 2008/6

Y1 - 2008/6

N2 - Context: Elevated levels of retinol binding protein-4 (RBP4) are positively correlated with insulin resistance, obesity, diabetes mellitus, and cardiovascular disease (CVD). Subclinical hypothyroidism (SCH) has also been associated with CVD; however, the factors linking SCH to CVD are not clear. Objective: The objective of the study was to evaluate risk factors for CVD in elderly patients grouped according to thyroid function. Design: 217 subjects (≥65 yr old) were randomly selected from a population and allocated to a euthyroid group (n = 177) and an SCH group (n = 40) on the basis of plasma concentrations of TSH and free T4. We included subjects with normal glucose tolerance by a 75-g oral glucose tolerance test and subjects with impaired fasting glucose. We measured anthropometric parameters, levels of fasting glucose and insulin, hemoglobin A1c, adiponectin, RBP4, lipid profiles, total body fat content, and the area of sc and visceral fat. Results: The SCH group had higher RBP4 levels than the euthyroid group, irrespective of body mass index and fat content. Subcutaneous and visceral fat areas and total body fat percentage did not differ between groups and were not correlated with RBP4 level. Other CVD risk factors did not differ between groups. RBP4 level was positively correlated with TSH level (r = 0.241, P = 0.001) after adjustment for age, sex, and body mass index. Conclusions: Plasma RBP4 levels were associated with SCH independent of obesity in elderly subjects with normal glucose tolerance, indicating that RBP4 level could be used as an index of CVD risk in SCH.

AB - Context: Elevated levels of retinol binding protein-4 (RBP4) are positively correlated with insulin resistance, obesity, diabetes mellitus, and cardiovascular disease (CVD). Subclinical hypothyroidism (SCH) has also been associated with CVD; however, the factors linking SCH to CVD are not clear. Objective: The objective of the study was to evaluate risk factors for CVD in elderly patients grouped according to thyroid function. Design: 217 subjects (≥65 yr old) were randomly selected from a population and allocated to a euthyroid group (n = 177) and an SCH group (n = 40) on the basis of plasma concentrations of TSH and free T4. We included subjects with normal glucose tolerance by a 75-g oral glucose tolerance test and subjects with impaired fasting glucose. We measured anthropometric parameters, levels of fasting glucose and insulin, hemoglobin A1c, adiponectin, RBP4, lipid profiles, total body fat content, and the area of sc and visceral fat. Results: The SCH group had higher RBP4 levels than the euthyroid group, irrespective of body mass index and fat content. Subcutaneous and visceral fat areas and total body fat percentage did not differ between groups and were not correlated with RBP4 level. Other CVD risk factors did not differ between groups. RBP4 level was positively correlated with TSH level (r = 0.241, P = 0.001) after adjustment for age, sex, and body mass index. Conclusions: Plasma RBP4 levels were associated with SCH independent of obesity in elderly subjects with normal glucose tolerance, indicating that RBP4 level could be used as an index of CVD risk in SCH.

UR - http://www.scopus.com/inward/record.url?scp=45149125047&partnerID=8YFLogxK

U2 - 10.1210/jc.2007-2536

DO - 10.1210/jc.2007-2536

M3 - Article

C2 - 18381580

AN - SCOPUS:45149125047

VL - 93

SP - 2313

EP - 2318

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 6

ER -