Abstract

Objectives: We investigated retinal change and its relationship with neurodegeneration markers in a prodromal Parkinson cohort. Methods: A total of 30 patients with idiopathic rapid eye movement sleep behavior disorder were recruited. Participants underwent olfactory testing, macular optical coherence tomography, microperimetry, contrast sensitivity test, and brain N-(3-[18F]fluoropropyl)-2-carbomethoxy-3-(4-iodophenyl) nortropane positron emission tomography. We measured the ganglion cell complex thicknesses and investigated its correlation with olfactory function and striatal dopamine transporter availability. A linear mixed-effect model was applied with adjustment for multiple comparisons. Results: The parafoveal ganglion-cell-complex thickness in this cohort lay between our healthy control and drug-naïve Parkinson's disease group data. Idiopathic rapid eye movement sleep behavior disorder patients also had contrast sensitivity impairment as in Parkinson's disease with a nonsignificant change in macular sensitivities. Macular ganglion cell complex thickness correlated with olfactory scores and with striatal dopamine transporter availabilities. Conclusions: Macular ganglion cell complex thinning may be a marker of neurodegeneration in prodromal Parkinson's disease.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalMovement Disorders
Volume35
Issue number2
DOIs
StatePublished - 1 Feb 2020

Keywords

  • Parkinson's disease
  • biomarker
  • idiopathic rapid eye movement sleep behavior disorder
  • optical coherence tomography
  • retina

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