RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

Marian C. Brady, Myzoon Ali, Kathryn VandenBerg, Linda J. Williams, Louise R. Williams, Masahiro Abo, Frank Becker, Audrey Bowen, Caitlin Brandenburg, Caterina Breitenstein, Stefanie Bruehl, David A. Copland, Tamara B. Cranfill, Marie di Pietro-Bachmann, Pamela Enderby, Joanne Fillingham, Federica Lucia Galli, Marialuisa Gandolfi, Bertrand Glize, Erin GodeckeNeil Hawkins, Katerina Hilari, Jacqueline Hinckley, Simon Horton, David Howard, Petra Jaecks, Elizabeth Jefferies, Luis M.T. Jesus, Maria Kambanaros, Eun Kyoung Kang, Eman M. Khedr, Anthony Pak Hin Kong, Tarja Kukkonen, Marina Laganaro, Matthew A.Lambon Ralph, Ann Charlotte Laska, Béatrice Leemann, Alexander P. Leff, Roxele R. Lima, Antje Lorenz, Brian MacWhinney, Rebecca Shisler Marshall, Flavia Mattioli, İlknur Maviş, Marcus Meinzer, Reza Nilipour, Enrique Noé, Nam Jong Paik, Rebecca Palmer, Ilias Papathanasiou, Brigida F. Patricio, Isabel Pavão Martins, Cathy Price, Tatjana Prizl Jakovac, Elizabeth Rochon, Miranda L. Rose, Charlotte Rosso, Ilona Rubi-Fessen, Marina B. Ruiter, Claerwen Snell, Benjamin Stahl, Jerzy P. Szaflarski, Shirley A. Thomas, Mieke van de Sandt-Koenderman, Ineke van der Meulen, Evy Visch-Brink, Linda Worrall, Heather Harris Wright

Research output: Contribution to journalArticle

Abstract

Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis. Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke. Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions. Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains. Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke. Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947).

Original languageEnglish
Pages (from-to)137-157
Number of pages21
JournalAphasiology
Volume34
Issue number2
DOIs
StatePublished - 1 Feb 2020

Fingerprint

Language Therapy
Speech Therapy
Aphasia
speech disorder
stroke
Stroke
language
Language
Databases
Network Meta-Analysis
Meta-analysis
Systematic Review
Therapy
Observational Studies
Registries
Reading
Randomized Controlled Trials
Communication
spoken language
Outcome Assessment (Health Care)

Keywords

  • IPD
  • Stroke
  • aphasia
  • complex intervention
  • meta-analysis

Cite this

Brady, Marian C. ; Ali, Myzoon ; VandenBerg, Kathryn ; Williams, Linda J. ; Williams, Louise R. ; Abo, Masahiro ; Becker, Frank ; Bowen, Audrey ; Brandenburg, Caitlin ; Breitenstein, Caterina ; Bruehl, Stefanie ; Copland, David A. ; Cranfill, Tamara B. ; Pietro-Bachmann, Marie di ; Enderby, Pamela ; Fillingham, Joanne ; Galli, Federica Lucia ; Gandolfi, Marialuisa ; Glize, Bertrand ; Godecke, Erin ; Hawkins, Neil ; Hilari, Katerina ; Hinckley, Jacqueline ; Horton, Simon ; Howard, David ; Jaecks, Petra ; Jefferies, Elizabeth ; Jesus, Luis M.T. ; Kambanaros, Maria ; Kang, Eun Kyoung ; Khedr, Eman M. ; Kong, Anthony Pak Hin ; Kukkonen, Tarja ; Laganaro, Marina ; Ralph, Matthew A.Lambon ; Laska, Ann Charlotte ; Leemann, Béatrice ; Leff, Alexander P. ; Lima, Roxele R. ; Lorenz, Antje ; MacWhinney, Brian ; Marshall, Rebecca Shisler ; Mattioli, Flavia ; Maviş, İlknur ; Meinzer, Marcus ; Nilipour, Reza ; Noé, Enrique ; Paik, Nam Jong ; Palmer, Rebecca ; Papathanasiou, Ilias ; Patricio, Brigida F. ; Martins, Isabel Pavão ; Price, Cathy ; Jakovac, Tatjana Prizl ; Rochon, Elizabeth ; Rose, Miranda L. ; Rosso, Charlotte ; Rubi-Fessen, Ilona ; Ruiter, Marina B. ; Snell, Claerwen ; Stahl, Benjamin ; Szaflarski, Jerzy P. ; Thomas, Shirley A. ; van de Sandt-Koenderman, Mieke ; van der Meulen, Ineke ; Visch-Brink, Evy ; Worrall, Linda ; Wright, Heather Harris. / RELEASE : a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia. In: Aphasiology. 2020 ; Vol. 34, No. 2. pp. 137-157.
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abstract = "Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis. Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke. Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions. Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains. Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke. Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947).",
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author = "Brady, {Marian C.} and Myzoon Ali and Kathryn VandenBerg and Williams, {Linda J.} and Williams, {Louise R.} and Masahiro Abo and Frank Becker and Audrey Bowen and Caitlin Brandenburg and Caterina Breitenstein and Stefanie Bruehl and Copland, {David A.} and Cranfill, {Tamara B.} and Pietro-Bachmann, {Marie di} and Pamela Enderby and Joanne Fillingham and Galli, {Federica Lucia} and Marialuisa Gandolfi and Bertrand Glize and Erin Godecke and Neil Hawkins and Katerina Hilari and Jacqueline Hinckley and Simon Horton and David Howard and Petra Jaecks and Elizabeth Jefferies and Jesus, {Luis M.T.} and Maria Kambanaros and Kang, {Eun Kyoung} and Khedr, {Eman M.} and Kong, {Anthony Pak Hin} and Tarja Kukkonen and Marina Laganaro and Ralph, {Matthew A.Lambon} and Laska, {Ann Charlotte} and B{\'e}atrice Leemann and Leff, {Alexander P.} and Lima, {Roxele R.} and Antje Lorenz and Brian MacWhinney and Marshall, {Rebecca Shisler} and Flavia Mattioli and İlknur Maviş and Marcus Meinzer and Reza Nilipour and Enrique No{\'e} and Paik, {Nam Jong} and Rebecca Palmer and Ilias Papathanasiou and Patricio, {Brigida F.} and Martins, {Isabel Pav{\~a}o} and Cathy Price and Jakovac, {Tatjana Prizl} and Elizabeth Rochon and Rose, {Miranda L.} and Charlotte Rosso and Ilona Rubi-Fessen and Ruiter, {Marina B.} and Claerwen Snell and Benjamin Stahl and Szaflarski, {Jerzy P.} and Thomas, {Shirley A.} and {van de Sandt-Koenderman}, Mieke and {van der Meulen}, Ineke and Evy Visch-Brink and Linda Worrall and Wright, {Heather Harris}",
year = "2020",
month = "2",
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doi = "10.1080/02687038.2019.1643003",
language = "English",
volume = "34",
pages = "137--157",
journal = "Aphasiology",
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Brady, MC, Ali, M, VandenBerg, K, Williams, LJ, Williams, LR, Abo, M, Becker, F, Bowen, A, Brandenburg, C, Breitenstein, C, Bruehl, S, Copland, DA, Cranfill, TB, Pietro-Bachmann, MD, Enderby, P, Fillingham, J, Galli, FL, Gandolfi, M, Glize, B, Godecke, E, Hawkins, N, Hilari, K, Hinckley, J, Horton, S, Howard, D, Jaecks, P, Jefferies, E, Jesus, LMT, Kambanaros, M, Kang, EK, Khedr, EM, Kong, APH, Kukkonen, T, Laganaro, M, Ralph, MAL, Laska, AC, Leemann, B, Leff, AP, Lima, RR, Lorenz, A, MacWhinney, B, Marshall, RS, Mattioli, F, Maviş, İ, Meinzer, M, Nilipour, R, Noé, E, Paik, NJ, Palmer, R, Papathanasiou, I, Patricio, BF, Martins, IP, Price, C, Jakovac, TP, Rochon, E, Rose, ML, Rosso, C, Rubi-Fessen, I, Ruiter, MB, Snell, C, Stahl, B, Szaflarski, JP, Thomas, SA, van de Sandt-Koenderman, M, van der Meulen, I, Visch-Brink, E, Worrall, L & Wright, HH 2020, 'RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia', Aphasiology, vol. 34, no. 2, pp. 137-157. https://doi.org/10.1080/02687038.2019.1643003

RELEASE : a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia. / Brady, Marian C.; Ali, Myzoon; VandenBerg, Kathryn; Williams, Linda J.; Williams, Louise R.; Abo, Masahiro; Becker, Frank; Bowen, Audrey; Brandenburg, Caitlin; Breitenstein, Caterina; Bruehl, Stefanie; Copland, David A.; Cranfill, Tamara B.; Pietro-Bachmann, Marie di; Enderby, Pamela; Fillingham, Joanne; Galli, Federica Lucia; Gandolfi, Marialuisa; Glize, Bertrand; Godecke, Erin; Hawkins, Neil; Hilari, Katerina; Hinckley, Jacqueline; Horton, Simon; Howard, David; Jaecks, Petra; Jefferies, Elizabeth; Jesus, Luis M.T.; Kambanaros, Maria; Kang, Eun Kyoung; Khedr, Eman M.; Kong, Anthony Pak Hin; Kukkonen, Tarja; Laganaro, Marina; Ralph, Matthew A.Lambon; Laska, Ann Charlotte; Leemann, Béatrice; Leff, Alexander P.; Lima, Roxele R.; Lorenz, Antje; MacWhinney, Brian; Marshall, Rebecca Shisler; Mattioli, Flavia; Maviş, İlknur; Meinzer, Marcus; Nilipour, Reza; Noé, Enrique; Paik, Nam Jong; Palmer, Rebecca; Papathanasiou, Ilias; Patricio, Brigida F.; Martins, Isabel Pavão; Price, Cathy; Jakovac, Tatjana Prizl; Rochon, Elizabeth; Rose, Miranda L.; Rosso, Charlotte; Rubi-Fessen, Ilona; Ruiter, Marina B.; Snell, Claerwen; Stahl, Benjamin; Szaflarski, Jerzy P.; Thomas, Shirley A.; van de Sandt-Koenderman, Mieke; van der Meulen, Ineke; Visch-Brink, Evy; Worrall, Linda; Wright, Heather Harris.

In: Aphasiology, Vol. 34, No. 2, 01.02.2020, p. 137-157.

Research output: Contribution to journalArticle

TY - JOUR

T1 - RELEASE

T2 - a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia

AU - Brady, Marian C.

AU - Ali, Myzoon

AU - VandenBerg, Kathryn

AU - Williams, Linda J.

AU - Williams, Louise R.

AU - Abo, Masahiro

AU - Becker, Frank

AU - Bowen, Audrey

AU - Brandenburg, Caitlin

AU - Breitenstein, Caterina

AU - Bruehl, Stefanie

AU - Copland, David A.

AU - Cranfill, Tamara B.

AU - Pietro-Bachmann, Marie di

AU - Enderby, Pamela

AU - Fillingham, Joanne

AU - Galli, Federica Lucia

AU - Gandolfi, Marialuisa

AU - Glize, Bertrand

AU - Godecke, Erin

AU - Hawkins, Neil

AU - Hilari, Katerina

AU - Hinckley, Jacqueline

AU - Horton, Simon

AU - Howard, David

AU - Jaecks, Petra

AU - Jefferies, Elizabeth

AU - Jesus, Luis M.T.

AU - Kambanaros, Maria

AU - Kang, Eun Kyoung

AU - Khedr, Eman M.

AU - Kong, Anthony Pak Hin

AU - Kukkonen, Tarja

AU - Laganaro, Marina

AU - Ralph, Matthew A.Lambon

AU - Laska, Ann Charlotte

AU - Leemann, Béatrice

AU - Leff, Alexander P.

AU - Lima, Roxele R.

AU - Lorenz, Antje

AU - MacWhinney, Brian

AU - Marshall, Rebecca Shisler

AU - Mattioli, Flavia

AU - Maviş, İlknur

AU - Meinzer, Marcus

AU - Nilipour, Reza

AU - Noé, Enrique

AU - Paik, Nam Jong

AU - Palmer, Rebecca

AU - Papathanasiou, Ilias

AU - Patricio, Brigida F.

AU - Martins, Isabel Pavão

AU - Price, Cathy

AU - Jakovac, Tatjana Prizl

AU - Rochon, Elizabeth

AU - Rose, Miranda L.

AU - Rosso, Charlotte

AU - Rubi-Fessen, Ilona

AU - Ruiter, Marina B.

AU - Snell, Claerwen

AU - Stahl, Benjamin

AU - Szaflarski, Jerzy P.

AU - Thomas, Shirley A.

AU - van de Sandt-Koenderman, Mieke

AU - van der Meulen, Ineke

AU - Visch-Brink, Evy

AU - Worrall, Linda

AU - Wright, Heather Harris

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis. Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke. Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions. Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains. Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke. Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947).

AB - Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis. Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke. Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions. Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains. Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke. Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947).

KW - IPD

KW - Stroke

KW - aphasia

KW - complex intervention

KW - meta-analysis

UR - http://www.scopus.com/inward/record.url?scp=85071578771&partnerID=8YFLogxK

U2 - 10.1080/02687038.2019.1643003

DO - 10.1080/02687038.2019.1643003

M3 - Article

AN - SCOPUS:85071578771

VL - 34

SP - 137

EP - 157

JO - Aphasiology

JF - Aphasiology

SN - 0268-7038

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