Relation between amniotic fluid infection or cytokine levels and hearing screen failure in infants at 32 wk gestation or less

Eun Young Jung, Byung Yoon Choi, Jihye Rhee, Jaehong Park, Soo Hyun Cho, Kyo Hoon Park

Research output: Contribution to journalArticle

5 Scopus citations


Background:To determine whether the presence of intra-amniotic infection and elevated proinflammatory cytokine levels in amniotic fluid (AF) are associated with failure in the newborn hearing screen (NHS) test in very preterm neonates.Methods:This is a retrospective cohort study of 112 premature singleton neonates born to women with preterm labor or preterm premature rupture of membranes at ≤32 wk. AF obtained through amniocentesis was cultured, and interleukin-6 (IL-6) and IL-8 levels were determined.Results:Fourteen (12.5%) neonates failed the NHS test. The prevalence of a positive AF culture was 40% (45/112). Multiple logistic regression analyses indicated that intra-amniotic infection was significantly associated with failure in the NHS test after adjusting for baseline covariates such as maternal white blood cell count (WBC) and periventricular leukomalacia. However, the IL-6 and IL-8 levels in AF were not significantly associated with hearing screen failure. Moreover, neither gestational age at birth nor birth weight was associated with NHS failure.Conclusion:The presence of intra-amniotic infection, but not elevated levels of AF IL-6 and IL-8, may contribute to the risk for failure in the NHS test in very preterm neonates. This finding suggests that intra-amniotic infection in utero might contribute to the development of congenital sensorineural hearing loss.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalPediatric Research
Issue number2
StatePublished - 1 Feb 2017

Cite this