Regulation of mRNA stability by ARE-binding proteins in synaptic plasticity and memory

Yong Seok Lee, Jin A. Lee, Bong Kiun Kaang

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Formation of long-term memories requires coordinated gene expression, which can be regulated at transcriptional, post-transcriptional, and translational levels. Post-transcriptional stabilization and destabilization of mRNAs provides precise temporal and spatial regulation of gene expression, which is critical for consolidation of synaptic plasticity and memory. mRNA stability is regulated by interactions between the cis-acting elements of mRNAs, such as adenine-uridine-rich elements (AREs), and the trans-acting elements, ARE-binding proteins (AUBPs). There are several AUBPs in the nervous system. Among AUBPs, Hu/ELAV-like proteins and AUF1 are the most studied mRNA stabilizing and destabilizing factors, respectively. Here, we summarize compelling evidence for critical roles of these AUBPs in synaptic plasticity, as well as learning and memory, in both vertebrates and invertebrates. Furthermore, we also briefly review the deregulations of AUBPs in neurological disorders.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalNeurobiology of Learning and Memory
Volume124
DOIs
StatePublished - 1 Oct 2015

Keywords

  • AUF1
  • ELAV
  • Long-term facilitation
  • Long-term potentiation
  • RNA-binding protein

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