Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer

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Abstract

Objective: We aimed to improve diagnostic accuracy of 18F- fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation. Materials and methods: 44 gastric cancer patients (M:F = 30:14, age ± std = 62.1 ± 14.5y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT. Results: 48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50% = 24/48) was significantly improved by regional PET/CT (75% = 36/48, p < 0.005). Sensitivity of whole body PET/CT (24.6% = 15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1% = 22/61, p < 0.01), whereas specificity of whole body PET/CT (99.3% = 285/287) was not compromised by regional PET/CT (98.3% = 282/287, p > 0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p = 0.0003). Conclusion: Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT.

Original languageEnglish
Pages (from-to)935-942
Number of pages8
JournalEuropean Journal of Radiology
Volume82
Issue number6
DOIs
StatePublished - 1 Jun 2013

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Economic Inflation
Deoxyglucose
Stomach Neoplasms
Stomach
Water
Neoplasms
Injections
Body Weight
Survival

Keywords

  • FDG
  • Gastric cancer
  • PET/CT
  • Staging

Cite this

@article{67cd974bf47246779eafb3e391a07ac1,
title = "Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer",
abstract = "Objective: We aimed to improve diagnostic accuracy of 18F- fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation. Materials and methods: 44 gastric cancer patients (M:F = 30:14, age ± std = 62.1 ± 14.5y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT. Results: 48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50{\%} = 24/48) was significantly improved by regional PET/CT (75{\%} = 36/48, p < 0.005). Sensitivity of whole body PET/CT (24.6{\%} = 15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1{\%} = 22/61, p < 0.01), whereas specificity of whole body PET/CT (99.3{\%} = 285/287) was not compromised by regional PET/CT (98.3{\%} = 282/287, p > 0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p = 0.0003). Conclusion: Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT.",
keywords = "FDG, Gastric cancer, PET/CT, Staging",
author = "Lee, {Soo Jin} and Lee, {Won Woo} and Yoon, {Hai Jeon} and Lee, {Ho Young} and Lee, {Kyoung Ho} and Kim, {Young Hoon} and Park, {Do Joong} and Kim, {Hyung Ho} and Young So and Kim, {Sang Eun}",
year = "2013",
month = "6",
day = "1",
doi = "10.1016/j.ejrad.2013.01.014",
language = "English",
volume = "82",
pages = "935--942",
journal = "European Journal of Radiology",
issn = "0720-048X",
publisher = "Elsevier Ireland Ltd",
number = "6",

}

TY - JOUR

T1 - Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer

AU - Lee, Soo Jin

AU - Lee, Won Woo

AU - Yoon, Hai Jeon

AU - Lee, Ho Young

AU - Lee, Kyoung Ho

AU - Kim, Young Hoon

AU - Park, Do Joong

AU - Kim, Hyung Ho

AU - So, Young

AU - Kim, Sang Eun

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Objective: We aimed to improve diagnostic accuracy of 18F- fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation. Materials and methods: 44 gastric cancer patients (M:F = 30:14, age ± std = 62.1 ± 14.5y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT. Results: 48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50% = 24/48) was significantly improved by regional PET/CT (75% = 36/48, p < 0.005). Sensitivity of whole body PET/CT (24.6% = 15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1% = 22/61, p < 0.01), whereas specificity of whole body PET/CT (99.3% = 285/287) was not compromised by regional PET/CT (98.3% = 282/287, p > 0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p = 0.0003). Conclusion: Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT.

AB - Objective: We aimed to improve diagnostic accuracy of 18F- fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation. Materials and methods: 44 gastric cancer patients (M:F = 30:14, age ± std = 62.1 ± 14.5y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT. Results: 48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50% = 24/48) was significantly improved by regional PET/CT (75% = 36/48, p < 0.005). Sensitivity of whole body PET/CT (24.6% = 15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1% = 22/61, p < 0.01), whereas specificity of whole body PET/CT (99.3% = 285/287) was not compromised by regional PET/CT (98.3% = 282/287, p > 0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p = 0.0003). Conclusion: Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT.

KW - FDG

KW - Gastric cancer

KW - PET/CT

KW - Staging

UR - http://www.scopus.com/inward/record.url?scp=84876915820&partnerID=8YFLogxK

U2 - 10.1016/j.ejrad.2013.01.014

DO - 10.1016/j.ejrad.2013.01.014

M3 - Article

C2 - 23410909

AN - SCOPUS:84876915820

VL - 82

SP - 935

EP - 942

JO - European Journal of Radiology

JF - European Journal of Radiology

SN - 0720-048X

IS - 6

ER -