Reduced frontal-subcortical white matter connectivity in association with suicidal ideation in major depressive disorder

Woo Jae Myung, C. E. Han, M. Fava, D. Mischoulon, G. I. Papakostas, J. Y. Heo, K. W. Kim, S. T. Kim, D. J.H. Kim, D. K. Kim, S. W. Seo, J. K. Seong, H. J. Jeon

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Major depressive disorder (MDD) and suicidal behavior have been associated with structural and functional changes in the brain. However, little is known regarding alterations of brain networks in MDD patients with suicidal ideation. We investigated whether or not MDD patients with suicidal ideation have different topological organizations of white matter networks compared with MDD patients without suicidal ideation. Participants consisted of 24 patients with MDD and suicidal ideation, 25 age-and gender-matched MDD patients without suicidal ideation and 31 healthy subjects. A network-based statistics (NBS) and a graph theoretical analysis were performed to assess differences in the inter-regional connectivity. Diffusion tensor imaging (DTI) was performed to assess topological changes according to suicidal ideation in MDD patients. The Scale for Suicide Ideation (SSI) and the Korean version of the Barrett Impulsiveness Scale (BIS) were used to assess the severity of suicidal ideation and impulsivity, respectively. Reduced structural connectivity in a characterized subnetwork was found in patients with MDD and suicidal ideation by utilizing NBS analysis. The subnetwork included the regions of the frontosubcortical circuits and the regions involved in executive function in the left hemisphere (rostral middle frontal, pallidum, superior parietal, frontal pole, caudate, putamen and thalamus). The graph theoretical analysis demonstrated that network measures of the left rostral middle frontal had a significant positive correlation with severity of SSI (r=0.59, P=0.02) and BIS (r=0.59, P=0.01). The total edge strength that was significantly associated with suicidal ideation did not differ between MDD patients without suicidal ideation and healthy subjects. Our findings suggest that the reduced frontosubcortical circuit of structural connectivity, which includes regions associated with executive function and impulsivity, appears to have a role in the emergence of suicidal ideation in MDD patients.

Original languageEnglish
Article numbere835
JournalTranslational psychiatry
Volume6
Issue number6
DOIs
StatePublished - 7 Jun 2016

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Suicidal Ideation
Major Depressive Disorder
Impulsive Behavior
Executive Function
Suicide
Healthy Volunteers
White Matter
Globus Pallidus
Diffusion Tensor Imaging
Putamen
Brain
Thalamus
Organizations

Cite this

Myung, Woo Jae ; Han, C. E. ; Fava, M. ; Mischoulon, D. ; Papakostas, G. I. ; Heo, J. Y. ; Kim, K. W. ; Kim, S. T. ; Kim, D. J.H. ; Kim, D. K. ; Seo, S. W. ; Seong, J. K. ; Jeon, H. J. / Reduced frontal-subcortical white matter connectivity in association with suicidal ideation in major depressive disorder. In: Translational psychiatry. 2016 ; Vol. 6, No. 6.
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abstract = "Major depressive disorder (MDD) and suicidal behavior have been associated with structural and functional changes in the brain. However, little is known regarding alterations of brain networks in MDD patients with suicidal ideation. We investigated whether or not MDD patients with suicidal ideation have different topological organizations of white matter networks compared with MDD patients without suicidal ideation. Participants consisted of 24 patients with MDD and suicidal ideation, 25 age-and gender-matched MDD patients without suicidal ideation and 31 healthy subjects. A network-based statistics (NBS) and a graph theoretical analysis were performed to assess differences in the inter-regional connectivity. Diffusion tensor imaging (DTI) was performed to assess topological changes according to suicidal ideation in MDD patients. The Scale for Suicide Ideation (SSI) and the Korean version of the Barrett Impulsiveness Scale (BIS) were used to assess the severity of suicidal ideation and impulsivity, respectively. Reduced structural connectivity in a characterized subnetwork was found in patients with MDD and suicidal ideation by utilizing NBS analysis. The subnetwork included the regions of the frontosubcortical circuits and the regions involved in executive function in the left hemisphere (rostral middle frontal, pallidum, superior parietal, frontal pole, caudate, putamen and thalamus). The graph theoretical analysis demonstrated that network measures of the left rostral middle frontal had a significant positive correlation with severity of SSI (r=0.59, P=0.02) and BIS (r=0.59, P=0.01). The total edge strength that was significantly associated with suicidal ideation did not differ between MDD patients without suicidal ideation and healthy subjects. Our findings suggest that the reduced frontosubcortical circuit of structural connectivity, which includes regions associated with executive function and impulsivity, appears to have a role in the emergence of suicidal ideation in MDD patients.",
author = "Myung, {Woo Jae} and Han, {C. E.} and M. Fava and D. Mischoulon and Papakostas, {G. I.} and Heo, {J. Y.} and Kim, {K. W.} and Kim, {S. T.} and Kim, {D. J.H.} and Kim, {D. K.} and Seo, {S. W.} and Seong, {J. K.} and Jeon, {H. J.}",
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Myung, WJ, Han, CE, Fava, M, Mischoulon, D, Papakostas, GI, Heo, JY, Kim, KW, Kim, ST, Kim, DJH, Kim, DK, Seo, SW, Seong, JK & Jeon, HJ 2016, 'Reduced frontal-subcortical white matter connectivity in association with suicidal ideation in major depressive disorder', Translational psychiatry, vol. 6, no. 6, e835. https://doi.org/10.1038/tp.2016.110

Reduced frontal-subcortical white matter connectivity in association with suicidal ideation in major depressive disorder. / Myung, Woo Jae; Han, C. E.; Fava, M.; Mischoulon, D.; Papakostas, G. I.; Heo, J. Y.; Kim, K. W.; Kim, S. T.; Kim, D. J.H.; Kim, D. K.; Seo, S. W.; Seong, J. K.; Jeon, H. J.

In: Translational psychiatry, Vol. 6, No. 6, e835, 07.06.2016.

Research output: Contribution to journalArticle

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T1 - Reduced frontal-subcortical white matter connectivity in association with suicidal ideation in major depressive disorder

AU - Myung, Woo Jae

AU - Han, C. E.

AU - Fava, M.

AU - Mischoulon, D.

AU - Papakostas, G. I.

AU - Heo, J. Y.

AU - Kim, K. W.

AU - Kim, S. T.

AU - Kim, D. J.H.

AU - Kim, D. K.

AU - Seo, S. W.

AU - Seong, J. K.

AU - Jeon, H. J.

PY - 2016/6/7

Y1 - 2016/6/7

N2 - Major depressive disorder (MDD) and suicidal behavior have been associated with structural and functional changes in the brain. However, little is known regarding alterations of brain networks in MDD patients with suicidal ideation. We investigated whether or not MDD patients with suicidal ideation have different topological organizations of white matter networks compared with MDD patients without suicidal ideation. Participants consisted of 24 patients with MDD and suicidal ideation, 25 age-and gender-matched MDD patients without suicidal ideation and 31 healthy subjects. A network-based statistics (NBS) and a graph theoretical analysis were performed to assess differences in the inter-regional connectivity. Diffusion tensor imaging (DTI) was performed to assess topological changes according to suicidal ideation in MDD patients. The Scale for Suicide Ideation (SSI) and the Korean version of the Barrett Impulsiveness Scale (BIS) were used to assess the severity of suicidal ideation and impulsivity, respectively. Reduced structural connectivity in a characterized subnetwork was found in patients with MDD and suicidal ideation by utilizing NBS analysis. The subnetwork included the regions of the frontosubcortical circuits and the regions involved in executive function in the left hemisphere (rostral middle frontal, pallidum, superior parietal, frontal pole, caudate, putamen and thalamus). The graph theoretical analysis demonstrated that network measures of the left rostral middle frontal had a significant positive correlation with severity of SSI (r=0.59, P=0.02) and BIS (r=0.59, P=0.01). The total edge strength that was significantly associated with suicidal ideation did not differ between MDD patients without suicidal ideation and healthy subjects. Our findings suggest that the reduced frontosubcortical circuit of structural connectivity, which includes regions associated with executive function and impulsivity, appears to have a role in the emergence of suicidal ideation in MDD patients.

AB - Major depressive disorder (MDD) and suicidal behavior have been associated with structural and functional changes in the brain. However, little is known regarding alterations of brain networks in MDD patients with suicidal ideation. We investigated whether or not MDD patients with suicidal ideation have different topological organizations of white matter networks compared with MDD patients without suicidal ideation. Participants consisted of 24 patients with MDD and suicidal ideation, 25 age-and gender-matched MDD patients without suicidal ideation and 31 healthy subjects. A network-based statistics (NBS) and a graph theoretical analysis were performed to assess differences in the inter-regional connectivity. Diffusion tensor imaging (DTI) was performed to assess topological changes according to suicidal ideation in MDD patients. The Scale for Suicide Ideation (SSI) and the Korean version of the Barrett Impulsiveness Scale (BIS) were used to assess the severity of suicidal ideation and impulsivity, respectively. Reduced structural connectivity in a characterized subnetwork was found in patients with MDD and suicidal ideation by utilizing NBS analysis. The subnetwork included the regions of the frontosubcortical circuits and the regions involved in executive function in the left hemisphere (rostral middle frontal, pallidum, superior parietal, frontal pole, caudate, putamen and thalamus). The graph theoretical analysis demonstrated that network measures of the left rostral middle frontal had a significant positive correlation with severity of SSI (r=0.59, P=0.02) and BIS (r=0.59, P=0.01). The total edge strength that was significantly associated with suicidal ideation did not differ between MDD patients without suicidal ideation and healthy subjects. Our findings suggest that the reduced frontosubcortical circuit of structural connectivity, which includes regions associated with executive function and impulsivity, appears to have a role in the emergence of suicidal ideation in MDD patients.

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