Rationale, design, and baseline characteristics of the EPICOR Asia study (Long-tErm follow-uP of antithrombotic management patterns in Acute CORonary Syndrome patients in Asia)

Yong Huo, Stephen W.L. Lee, Jitendra P.S. Sawhney, Hyo Soo Kim, Rungroj Krittayaphong, Vo T. Nhan, Angeles Alonso-Garcia, Ya Ling Han, Junbo Ge, Chee Tang Chin, Tiong K. Ong, Stephen Jan, Yohji Itoh, Ana Maria Vega, Stuart Pocock

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Abstract

Background In-hospital and postdischarge mortality for acute coronary syndromes (ACS) vary across Asia and remain generally poorer than globally. The relationship between real-life antithrombotic management patterns (AMPs) and ACS-related outcomes in Asia is unclear. Methods EPICOR Asia (Long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients in Asia) (NCT01361386) is a prospective, multinational, observational study of patients discharged after hospitalization for an ACS, with 2-year follow-up. The aim is to describe short- and long-term (up to 2 years post-index event) AMPs in patients hospitalized for ACS and to record clinical outcomes, healthcare resource use, and self-reported health status. Pre- and in-hospital management, AMPs, and associated outcomes, with particular focus on ischemic and bleeding events, will be recorded during the 2-year follow up. Results Between June 2011 and May 2012, 13 005 patients were enrolled. From these, 12 922 patients surviving an ACS (6616 with STEMI, 2570 with NSTEMI, and 3736 with UA) were eligible for inclusion from 219 hospitals across 8 countries and regions in Asia: China (n = 8214), Hong Kong (n = 177), India (n = 2468), Malaysia (n = 100), Singapore (n = 93), South Korea (n = 705), Thailand (n = 957), and Vietnam (n = 208). Conclusions EPICOR Asia will provide information regarding clinical management and AMPs for ACS patients in Asia. Impact of AMPs on clinical outcomes, healthcare resource use, and self-reported health status both during hospitalization and up to 2 years after discharge will also be described.

Original languageEnglish
Pages (from-to)511-519
Number of pages9
JournalClinical Cardiology
Volume38
Issue number9
DOIs
StatePublished - 1 Sep 2015

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Acute Coronary Syndrome
Health Status
Hospitalization
Delivery of Health Care
Republic of Korea
Vietnam
Malaysia
Singapore
Hong Kong
Thailand
Hospital Mortality
Observational Studies
India
China
Hemorrhage

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Huo, Yong ; Lee, Stephen W.L. ; Sawhney, Jitendra P.S. ; Kim, Hyo Soo ; Krittayaphong, Rungroj ; Nhan, Vo T. ; Alonso-Garcia, Angeles ; Han, Ya Ling ; Ge, Junbo ; Chin, Chee Tang ; Ong, Tiong K. ; Jan, Stephen ; Itoh, Yohji ; Vega, Ana Maria ; Pocock, Stuart. / Rationale, design, and baseline characteristics of the EPICOR Asia study (Long-tErm follow-uP of antithrombotic management patterns in Acute CORonary Syndrome patients in Asia). In: Clinical Cardiology. 2015 ; Vol. 38, No. 9. pp. 511-519.
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title = "Rationale, design, and baseline characteristics of the EPICOR Asia study (Long-tErm follow-uP of antithrombotic management patterns in Acute CORonary Syndrome patients in Asia)",
abstract = "Background In-hospital and postdischarge mortality for acute coronary syndromes (ACS) vary across Asia and remain generally poorer than globally. The relationship between real-life antithrombotic management patterns (AMPs) and ACS-related outcomes in Asia is unclear. Methods EPICOR Asia (Long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients in Asia) (NCT01361386) is a prospective, multinational, observational study of patients discharged after hospitalization for an ACS, with 2-year follow-up. The aim is to describe short- and long-term (up to 2 years post-index event) AMPs in patients hospitalized for ACS and to record clinical outcomes, healthcare resource use, and self-reported health status. Pre- and in-hospital management, AMPs, and associated outcomes, with particular focus on ischemic and bleeding events, will be recorded during the 2-year follow up. Results Between June 2011 and May 2012, 13 005 patients were enrolled. From these, 12 922 patients surviving an ACS (6616 with STEMI, 2570 with NSTEMI, and 3736 with UA) were eligible for inclusion from 219 hospitals across 8 countries and regions in Asia: China (n = 8214), Hong Kong (n = 177), India (n = 2468), Malaysia (n = 100), Singapore (n = 93), South Korea (n = 705), Thailand (n = 957), and Vietnam (n = 208). Conclusions EPICOR Asia will provide information regarding clinical management and AMPs for ACS patients in Asia. Impact of AMPs on clinical outcomes, healthcare resource use, and self-reported health status both during hospitalization and up to 2 years after discharge will also be described.",
author = "Yong Huo and Lee, {Stephen W.L.} and Sawhney, {Jitendra P.S.} and Kim, {Hyo Soo} and Rungroj Krittayaphong and Nhan, {Vo T.} and Angeles Alonso-Garcia and Han, {Ya Ling} and Junbo Ge and Chin, {Chee Tang} and Ong, {Tiong K.} and Stephen Jan and Yohji Itoh and Vega, {Ana Maria} and Stuart Pocock",
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Huo, Y, Lee, SWL, Sawhney, JPS, Kim, HS, Krittayaphong, R, Nhan, VT, Alonso-Garcia, A, Han, YL, Ge, J, Chin, CT, Ong, TK, Jan, S, Itoh, Y, Vega, AM & Pocock, S 2015, 'Rationale, design, and baseline characteristics of the EPICOR Asia study (Long-tErm follow-uP of antithrombotic management patterns in Acute CORonary Syndrome patients in Asia)', Clinical Cardiology, vol. 38, no. 9, pp. 511-519. https://doi.org/10.1002/clc.22431

Rationale, design, and baseline characteristics of the EPICOR Asia study (Long-tErm follow-uP of antithrombotic management patterns in Acute CORonary Syndrome patients in Asia). / Huo, Yong; Lee, Stephen W.L.; Sawhney, Jitendra P.S.; Kim, Hyo Soo; Krittayaphong, Rungroj; Nhan, Vo T.; Alonso-Garcia, Angeles; Han, Ya Ling; Ge, Junbo; Chin, Chee Tang; Ong, Tiong K.; Jan, Stephen; Itoh, Yohji; Vega, Ana Maria; Pocock, Stuart.

In: Clinical Cardiology, Vol. 38, No. 9, 01.09.2015, p. 511-519.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Rationale, design, and baseline characteristics of the EPICOR Asia study (Long-tErm follow-uP of antithrombotic management patterns in Acute CORonary Syndrome patients in Asia)

AU - Huo, Yong

AU - Lee, Stephen W.L.

AU - Sawhney, Jitendra P.S.

AU - Kim, Hyo Soo

AU - Krittayaphong, Rungroj

AU - Nhan, Vo T.

AU - Alonso-Garcia, Angeles

AU - Han, Ya Ling

AU - Ge, Junbo

AU - Chin, Chee Tang

AU - Ong, Tiong K.

AU - Jan, Stephen

AU - Itoh, Yohji

AU - Vega, Ana Maria

AU - Pocock, Stuart

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Background In-hospital and postdischarge mortality for acute coronary syndromes (ACS) vary across Asia and remain generally poorer than globally. The relationship between real-life antithrombotic management patterns (AMPs) and ACS-related outcomes in Asia is unclear. Methods EPICOR Asia (Long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients in Asia) (NCT01361386) is a prospective, multinational, observational study of patients discharged after hospitalization for an ACS, with 2-year follow-up. The aim is to describe short- and long-term (up to 2 years post-index event) AMPs in patients hospitalized for ACS and to record clinical outcomes, healthcare resource use, and self-reported health status. Pre- and in-hospital management, AMPs, and associated outcomes, with particular focus on ischemic and bleeding events, will be recorded during the 2-year follow up. Results Between June 2011 and May 2012, 13 005 patients were enrolled. From these, 12 922 patients surviving an ACS (6616 with STEMI, 2570 with NSTEMI, and 3736 with UA) were eligible for inclusion from 219 hospitals across 8 countries and regions in Asia: China (n = 8214), Hong Kong (n = 177), India (n = 2468), Malaysia (n = 100), Singapore (n = 93), South Korea (n = 705), Thailand (n = 957), and Vietnam (n = 208). Conclusions EPICOR Asia will provide information regarding clinical management and AMPs for ACS patients in Asia. Impact of AMPs on clinical outcomes, healthcare resource use, and self-reported health status both during hospitalization and up to 2 years after discharge will also be described.

AB - Background In-hospital and postdischarge mortality for acute coronary syndromes (ACS) vary across Asia and remain generally poorer than globally. The relationship between real-life antithrombotic management patterns (AMPs) and ACS-related outcomes in Asia is unclear. Methods EPICOR Asia (Long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients in Asia) (NCT01361386) is a prospective, multinational, observational study of patients discharged after hospitalization for an ACS, with 2-year follow-up. The aim is to describe short- and long-term (up to 2 years post-index event) AMPs in patients hospitalized for ACS and to record clinical outcomes, healthcare resource use, and self-reported health status. Pre- and in-hospital management, AMPs, and associated outcomes, with particular focus on ischemic and bleeding events, will be recorded during the 2-year follow up. Results Between June 2011 and May 2012, 13 005 patients were enrolled. From these, 12 922 patients surviving an ACS (6616 with STEMI, 2570 with NSTEMI, and 3736 with UA) were eligible for inclusion from 219 hospitals across 8 countries and regions in Asia: China (n = 8214), Hong Kong (n = 177), India (n = 2468), Malaysia (n = 100), Singapore (n = 93), South Korea (n = 705), Thailand (n = 957), and Vietnam (n = 208). Conclusions EPICOR Asia will provide information regarding clinical management and AMPs for ACS patients in Asia. Impact of AMPs on clinical outcomes, healthcare resource use, and self-reported health status both during hospitalization and up to 2 years after discharge will also be described.

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U2 - 10.1002/clc.22431

DO - 10.1002/clc.22431

M3 - Article

C2 - 26206158

AN - SCOPUS:84942837158

VL - 38

SP - 511

EP - 519

JO - Clinical Cardiology

JF - Clinical Cardiology

SN - 0160-9289

IS - 9

ER -