Ratio of triglyceride to high-density lipoprotein cholesterol and risk of major cardiovascular events in kidney transplant recipients

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Abstract

Background: Dyslipidemia is common in kidney transplant (KT) recipients. We analyzed the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) in KT recipients to identify risk factors for major cardiovascular events (MACE). Methods: We retrospectively included KT recipients with a lipid profile performed 1 year after transplantation. We classified patients according to the TG/HDL-C divided into quintiles. Subsequently, we analyzed the association between TG/HDL-C and MACE, defined as heart failure, coronary artery disease, and cerebrovascular disease confirmed by imaging studies. Results: A total of 1301 KT recipients were enrolled. The median follow-up duration was 7.4 years (interquartile range 4.4–11.1 years). During the follow-up period, 80 (6.2%) patients developed MACE, which included 38 of unstable anginas, 9 of MIs, 19 of heart failures, 18 of cerebral infarcts, and 4 of cerebral hemorrhages. The fourth and fifth quintiles of TG/HDL-C showed a significantly increased risk of MACE [fourth quintile: adjusted hazard ratio (aHR), 3.38; 95% confidence interval (CI) 1.44–7.95; p = 0.005, fifth quintile: aHR, 2.67; 95% CI 1.13–6.30; p = 0.02]) compared to the second quintile of TG/HDL-C. This association is particularly evident in subgroups of non-DM, HTN, no history of CVD, and statin users. Conclusions: Higher TG/HDL-C levels may be associated with MACE risk in KT recipients.

Original languageEnglish
Pages (from-to)1407-1417
Number of pages11
JournalClinical and Experimental Nephrology
Volume23
Issue number12
DOIs
StatePublished - 1 Dec 2019

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HDL Cholesterol
Triglycerides
Kidney
Heart Failure
Confidence Intervals
Cerebrovascular Disorders
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cerebral Hemorrhage
Dyslipidemias
Coronary Artery Disease
Transplantation
Transplant Recipients
Lipids

Keywords

  • Cardiovascular
  • Cholesterol
  • Kidney transplantation
  • Statins
  • TG/HDL-C

Cite this

@article{5153685c15624770aa788987c20f3213,
title = "Ratio of triglyceride to high-density lipoprotein cholesterol and risk of major cardiovascular events in kidney transplant recipients",
abstract = "Background: Dyslipidemia is common in kidney transplant (KT) recipients. We analyzed the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) in KT recipients to identify risk factors for major cardiovascular events (MACE). Methods: We retrospectively included KT recipients with a lipid profile performed 1 year after transplantation. We classified patients according to the TG/HDL-C divided into quintiles. Subsequently, we analyzed the association between TG/HDL-C and MACE, defined as heart failure, coronary artery disease, and cerebrovascular disease confirmed by imaging studies. Results: A total of 1301 KT recipients were enrolled. The median follow-up duration was 7.4 years (interquartile range 4.4–11.1 years). During the follow-up period, 80 (6.2{\%}) patients developed MACE, which included 38 of unstable anginas, 9 of MIs, 19 of heart failures, 18 of cerebral infarcts, and 4 of cerebral hemorrhages. The fourth and fifth quintiles of TG/HDL-C showed a significantly increased risk of MACE [fourth quintile: adjusted hazard ratio (aHR), 3.38; 95{\%} confidence interval (CI) 1.44–7.95; p = 0.005, fifth quintile: aHR, 2.67; 95{\%} CI 1.13–6.30; p = 0.02]) compared to the second quintile of TG/HDL-C. This association is particularly evident in subgroups of non-DM, HTN, no history of CVD, and statin users. Conclusions: Higher TG/HDL-C levels may be associated with MACE risk in KT recipients.",
keywords = "Cardiovascular, Cholesterol, Kidney transplantation, Statins, TG/HDL-C",
author = "Kim, {Ji Eun} and Yu, {Mi Yeon} and Kim, {Yong Chul} and Min, {Sang il} and Jongwon Ha and Lee, {Jung Pyo} and Kim, {Dong Ki} and Oh, {Kook Hwan} and Joo, {Kwon Wook} and Curie Ahn and Kim, {Yon Su} and Hajeong Lee",
year = "2019",
month = "12",
day = "1",
doi = "10.1007/s10157-019-01776-9",
language = "English",
volume = "23",
pages = "1407--1417",
journal = "Clinical and Experimental Nephrology",
issn = "1342-1751",
publisher = "Springer Japan",
number = "12",

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TY - JOUR

T1 - Ratio of triglyceride to high-density lipoprotein cholesterol and risk of major cardiovascular events in kidney transplant recipients

AU - Kim, Ji Eun

AU - Yu, Mi Yeon

AU - Kim, Yong Chul

AU - Min, Sang il

AU - Ha, Jongwon

AU - Lee, Jung Pyo

AU - Kim, Dong Ki

AU - Oh, Kook Hwan

AU - Joo, Kwon Wook

AU - Ahn, Curie

AU - Kim, Yon Su

AU - Lee, Hajeong

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Background: Dyslipidemia is common in kidney transplant (KT) recipients. We analyzed the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) in KT recipients to identify risk factors for major cardiovascular events (MACE). Methods: We retrospectively included KT recipients with a lipid profile performed 1 year after transplantation. We classified patients according to the TG/HDL-C divided into quintiles. Subsequently, we analyzed the association between TG/HDL-C and MACE, defined as heart failure, coronary artery disease, and cerebrovascular disease confirmed by imaging studies. Results: A total of 1301 KT recipients were enrolled. The median follow-up duration was 7.4 years (interquartile range 4.4–11.1 years). During the follow-up period, 80 (6.2%) patients developed MACE, which included 38 of unstable anginas, 9 of MIs, 19 of heart failures, 18 of cerebral infarcts, and 4 of cerebral hemorrhages. The fourth and fifth quintiles of TG/HDL-C showed a significantly increased risk of MACE [fourth quintile: adjusted hazard ratio (aHR), 3.38; 95% confidence interval (CI) 1.44–7.95; p = 0.005, fifth quintile: aHR, 2.67; 95% CI 1.13–6.30; p = 0.02]) compared to the second quintile of TG/HDL-C. This association is particularly evident in subgroups of non-DM, HTN, no history of CVD, and statin users. Conclusions: Higher TG/HDL-C levels may be associated with MACE risk in KT recipients.

AB - Background: Dyslipidemia is common in kidney transplant (KT) recipients. We analyzed the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) in KT recipients to identify risk factors for major cardiovascular events (MACE). Methods: We retrospectively included KT recipients with a lipid profile performed 1 year after transplantation. We classified patients according to the TG/HDL-C divided into quintiles. Subsequently, we analyzed the association between TG/HDL-C and MACE, defined as heart failure, coronary artery disease, and cerebrovascular disease confirmed by imaging studies. Results: A total of 1301 KT recipients were enrolled. The median follow-up duration was 7.4 years (interquartile range 4.4–11.1 years). During the follow-up period, 80 (6.2%) patients developed MACE, which included 38 of unstable anginas, 9 of MIs, 19 of heart failures, 18 of cerebral infarcts, and 4 of cerebral hemorrhages. The fourth and fifth quintiles of TG/HDL-C showed a significantly increased risk of MACE [fourth quintile: adjusted hazard ratio (aHR), 3.38; 95% confidence interval (CI) 1.44–7.95; p = 0.005, fifth quintile: aHR, 2.67; 95% CI 1.13–6.30; p = 0.02]) compared to the second quintile of TG/HDL-C. This association is particularly evident in subgroups of non-DM, HTN, no history of CVD, and statin users. Conclusions: Higher TG/HDL-C levels may be associated with MACE risk in KT recipients.

KW - Cardiovascular

KW - Cholesterol

KW - Kidney transplantation

KW - Statins

KW - TG/HDL-C

UR - http://www.scopus.com/inward/record.url?scp=85071499077&partnerID=8YFLogxK

U2 - 10.1007/s10157-019-01776-9

DO - 10.1007/s10157-019-01776-9

M3 - Article

C2 - 31468232

AN - SCOPUS:85071499077

VL - 23

SP - 1407

EP - 1417

JO - Clinical and Experimental Nephrology

JF - Clinical and Experimental Nephrology

SN - 1342-1751

IS - 12

ER -