Rate of three-dimensional neuroretinal rim thinning in glaucomatous eyes with optic disc haemorrhage

Yong Woo Kim, Won June Lee, Bo Ram Seol, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park

Research output: Contribution to journalArticle

Abstract

Background To investigate the thinning rate of three-dimensional neuroretinal rim thickness (3D-NRT) in glaucoma eyes with optic disc haemorrhage (DH) and its relationship to retinal nerve fibre layer thickness (RNFLT) progression. Methods Ninety-five (95) eyes of 95 glaucoma patients with initial DH in the inferotemporal (n=69) and superotemporal (n=26) regions and 48 eyes of 48 glaucoma patients without DH were retrospectively reviewed. The rates of change for 3D-NRT and RNFLT were compared by linear mixed-effect model. For the direct comparison between 3D-NRT and RNFLT, dynamic-range-based normalised coefficient was used. The effect of DH frequency on the rates of thinning of 3D-NRT and RNFLT was evaluated. Results During a mean 7-year follow-up, the rates of thinning of 3D-NRT (-5.69±4.88 μm/year) and RNFLT (-2.03±2.03 μm/year) at 7 o'clock were faster than those at other locations (all p<0.05) in DH eyes. The dynamic-range-based normalised rate of thinning was significantly faster for RNFLT (-2.06%±1.62%/year) than for 3D-NRT (-1.15%±1.10%/year, p<0.001) in DH eyes, but not in non-DH eyes (p=0.43). DH frequency in the inferotemporal region was associated with the thinning rate of 3D-NRT as well as RNFLT. Conclusion DH eyes are associated with the progression of both 3D-NRT and RNFLT, especially in the inferotemporal region. DH eyes show a relatively faster thinning rate of average RNFLT than 3D-NRT. The frequency of DH can affect the progression of 3D-NRT as well as RNFLT.

Original languageEnglish
Pages (from-to)648-654
Number of pages7
JournalBritish Journal of Ophthalmology
Volume104
Issue number5
DOIs
StatePublished - 1 May 2020

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Keywords

  • glaucoma
  • imaging
  • optic nerve

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