Quantitative Single-Photon Emission Computed Tomography/Computed Tomography for Glomerular Filtration Rate Measurement

Yeon koo Kang, Sohyun Park, Min Seok Suh, Seok Soo Byun, Dong Wan Chae, Won Woo Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: We propose a quantitative Tc-99m diethylenetriaminepentaacetic acid (DTPA) single-photon emission computed tomography/computed tomography (SPECT/CT) for glomerular filtration rate (GFR) measurement. Methods: Quantitative SPECT/CT data obtained at 2–3 min post-Tc-99m DTPA injection (370 MBq) were used to determine % injected doses (%IDs) for individual kidneys. The reproducibility of %ID measurement was tested and compared with planar scintigraphy. Cr-51 ethylenediaminetetraacetic acid (EDTA) GFR was used as reference standard. Nine young volunteers, representing normal GFR, and ten older volunteers, reflecting impaired GFR, were enrolled. The established GFR equation derived from these volunteers was applied to 19 renal tumor patients post-partial nephrectomy. Results: At 2−3 min, %ID was most reproducible with the highest intraclass correlation (ICC) (0.9379) and lowest % coefficient of variation (CV) (6.5259%), which were more reliable than the ICC (0.9368) and %CV (6.7689%) of planar scintigraphy. Cr-51 EDTA GFR (93.16 ± 24.81 ml/min) correlated significantly with %ID (7.66 ± 2.15%, r = 0.7906, p = 0.0001), yielding an equation: Cr-51 EDTA GFR (ml/min) = (%ID × 9.1462) + 23.0653. This equation revealed significant decreases in total and nephrectomized kidney GFR (p = 0.0012 and p < 0.0001, respectively) from preoperative to 3-month postoperative measurements. Conclusions: Quantitative Tc-99m DTPA SPECT/CT produces reliable and clinically applicable %ID estimates that translate to the GFR of individual kidneys.

Original languageEnglish
Pages (from-to)338-346
Number of pages9
JournalNuclear Medicine and Molecular Imaging
Volume51
Issue number4
DOIs
StatePublished - 1 Dec 2017

Fingerprint

Glomerular Filtration Rate
Edetic Acid
Kidney
Radionuclide Imaging
Acids
Volunteers
Single Photon Emission Computed Tomography Computed Tomography
Nephrectomy
Healthy Volunteers
Injections

Keywords

  • Computed tomography
  • Cr-51 EDTA
  • Glomerular filtration rate
  • Single-photon emission computed tomography
  • Tc-99m DTPA

Cite this

@article{89cb982144e54b8a9399093e087efbf6,
title = "Quantitative Single-Photon Emission Computed Tomography/Computed Tomography for Glomerular Filtration Rate Measurement",
abstract = "Purpose: We propose a quantitative Tc-99m diethylenetriaminepentaacetic acid (DTPA) single-photon emission computed tomography/computed tomography (SPECT/CT) for glomerular filtration rate (GFR) measurement. Methods: Quantitative SPECT/CT data obtained at 2–3 min post-Tc-99m DTPA injection (370 MBq) were used to determine {\%} injected doses ({\%}IDs) for individual kidneys. The reproducibility of {\%}ID measurement was tested and compared with planar scintigraphy. Cr-51 ethylenediaminetetraacetic acid (EDTA) GFR was used as reference standard. Nine young volunteers, representing normal GFR, and ten older volunteers, reflecting impaired GFR, were enrolled. The established GFR equation derived from these volunteers was applied to 19 renal tumor patients post-partial nephrectomy. Results: At 2−3 min, {\%}ID was most reproducible with the highest intraclass correlation (ICC) (0.9379) and lowest {\%} coefficient of variation (CV) (6.5259{\%}), which were more reliable than the ICC (0.9368) and {\%}CV (6.7689{\%}) of planar scintigraphy. Cr-51 EDTA GFR (93.16 ± 24.81 ml/min) correlated significantly with {\%}ID (7.66 ± 2.15{\%}, r = 0.7906, p = 0.0001), yielding an equation: Cr-51 EDTA GFR (ml/min) = ({\%}ID × 9.1462) + 23.0653. This equation revealed significant decreases in total and nephrectomized kidney GFR (p = 0.0012 and p < 0.0001, respectively) from preoperative to 3-month postoperative measurements. Conclusions: Quantitative Tc-99m DTPA SPECT/CT produces reliable and clinically applicable {\%}ID estimates that translate to the GFR of individual kidneys.",
keywords = "Computed tomography, Cr-51 EDTA, Glomerular filtration rate, Single-photon emission computed tomography, Tc-99m DTPA",
author = "Kang, {Yeon koo} and Sohyun Park and Suh, {Min Seok} and Byun, {Seok Soo} and Chae, {Dong Wan} and Lee, {Won Woo}",
year = "2017",
month = "12",
day = "1",
doi = "10.1007/s13139-017-0491-8",
language = "English",
volume = "51",
pages = "338--346",
journal = "Nuclear Medicine and Molecular Imaging",
issn = "1869-3474",
publisher = "Springer Verlag",
number = "4",

}

Quantitative Single-Photon Emission Computed Tomography/Computed Tomography for Glomerular Filtration Rate Measurement. / Kang, Yeon koo; Park, Sohyun; Suh, Min Seok; Byun, Seok Soo; Chae, Dong Wan; Lee, Won Woo.

In: Nuclear Medicine and Molecular Imaging, Vol. 51, No. 4, 01.12.2017, p. 338-346.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Quantitative Single-Photon Emission Computed Tomography/Computed Tomography for Glomerular Filtration Rate Measurement

AU - Kang, Yeon koo

AU - Park, Sohyun

AU - Suh, Min Seok

AU - Byun, Seok Soo

AU - Chae, Dong Wan

AU - Lee, Won Woo

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Purpose: We propose a quantitative Tc-99m diethylenetriaminepentaacetic acid (DTPA) single-photon emission computed tomography/computed tomography (SPECT/CT) for glomerular filtration rate (GFR) measurement. Methods: Quantitative SPECT/CT data obtained at 2–3 min post-Tc-99m DTPA injection (370 MBq) were used to determine % injected doses (%IDs) for individual kidneys. The reproducibility of %ID measurement was tested and compared with planar scintigraphy. Cr-51 ethylenediaminetetraacetic acid (EDTA) GFR was used as reference standard. Nine young volunteers, representing normal GFR, and ten older volunteers, reflecting impaired GFR, were enrolled. The established GFR equation derived from these volunteers was applied to 19 renal tumor patients post-partial nephrectomy. Results: At 2−3 min, %ID was most reproducible with the highest intraclass correlation (ICC) (0.9379) and lowest % coefficient of variation (CV) (6.5259%), which were more reliable than the ICC (0.9368) and %CV (6.7689%) of planar scintigraphy. Cr-51 EDTA GFR (93.16 ± 24.81 ml/min) correlated significantly with %ID (7.66 ± 2.15%, r = 0.7906, p = 0.0001), yielding an equation: Cr-51 EDTA GFR (ml/min) = (%ID × 9.1462) + 23.0653. This equation revealed significant decreases in total and nephrectomized kidney GFR (p = 0.0012 and p < 0.0001, respectively) from preoperative to 3-month postoperative measurements. Conclusions: Quantitative Tc-99m DTPA SPECT/CT produces reliable and clinically applicable %ID estimates that translate to the GFR of individual kidneys.

AB - Purpose: We propose a quantitative Tc-99m diethylenetriaminepentaacetic acid (DTPA) single-photon emission computed tomography/computed tomography (SPECT/CT) for glomerular filtration rate (GFR) measurement. Methods: Quantitative SPECT/CT data obtained at 2–3 min post-Tc-99m DTPA injection (370 MBq) were used to determine % injected doses (%IDs) for individual kidneys. The reproducibility of %ID measurement was tested and compared with planar scintigraphy. Cr-51 ethylenediaminetetraacetic acid (EDTA) GFR was used as reference standard. Nine young volunteers, representing normal GFR, and ten older volunteers, reflecting impaired GFR, were enrolled. The established GFR equation derived from these volunteers was applied to 19 renal tumor patients post-partial nephrectomy. Results: At 2−3 min, %ID was most reproducible with the highest intraclass correlation (ICC) (0.9379) and lowest % coefficient of variation (CV) (6.5259%), which were more reliable than the ICC (0.9368) and %CV (6.7689%) of planar scintigraphy. Cr-51 EDTA GFR (93.16 ± 24.81 ml/min) correlated significantly with %ID (7.66 ± 2.15%, r = 0.7906, p = 0.0001), yielding an equation: Cr-51 EDTA GFR (ml/min) = (%ID × 9.1462) + 23.0653. This equation revealed significant decreases in total and nephrectomized kidney GFR (p = 0.0012 and p < 0.0001, respectively) from preoperative to 3-month postoperative measurements. Conclusions: Quantitative Tc-99m DTPA SPECT/CT produces reliable and clinically applicable %ID estimates that translate to the GFR of individual kidneys.

KW - Computed tomography

KW - Cr-51 EDTA

KW - Glomerular filtration rate

KW - Single-photon emission computed tomography

KW - Tc-99m DTPA

UR - http://www.scopus.com/inward/record.url?scp=85037661716&partnerID=8YFLogxK

U2 - 10.1007/s13139-017-0491-8

DO - 10.1007/s13139-017-0491-8

M3 - Article

AN - SCOPUS:85037661716

VL - 51

SP - 338

EP - 346

JO - Nuclear Medicine and Molecular Imaging

JF - Nuclear Medicine and Molecular Imaging

SN - 1869-3474

IS - 4

ER -