qMTNet: Accelerated quantitative magnetization transfer imaging with artificial neural networks

Huan Minh Luu, Dong Hyun Kim, Jae Woong Kim, Seung Hong Choi, Sung Hong Park

Research output: Contribution to journalArticlepeer-review


Purpose: To develop a set of artificial neural networks, collectively termed qMTNet, to accelerate data acquisition and fitting for quantitative magnetization transfer (qMT) imaging. Methods: Conventional and interslice qMT data were acquired with two flip angles at six offset frequencies from seven subjects for developing the networks and from four young and four older subjects for testing the generalizability. Two subnetworks, qMTNet-acq and qMTNet-fit, were developed and trained to accelerate data acquisition and fitting, respectively. qMTNet-2 is the sequential application of qMTNet-acq and qMTNet-fit to produce qMT parameters (exchange rate, pool fraction) from undersampled qMT data (two offset frequencies rather than six). qMTNet-1 is one single integrated network having the same functionality as qMTNet-2. qMTNet-fit was compared with a Gaussian kernel-based fitting. qMT parameters generated by the networks were compared with those from ground truth fitted with a dictionary-driven approach. Results: The proposed networks achieved high peak signal-to-noise ratio (>30) and structural similarity index (>97) in reference to the ground truth. qMTNet-fit produced qMT parameters in concordance with the ground truth with better performance than the Gaussian kernel-based fitting. qMTNet-2 and qMTNet-1 could accelerate data acquisition at threefold and accelerate fitting at 5800- and 4218-fold, respectively. qMTNet-1 showed slightly better performance than qMTNet-2, whereas qMTNet-2 was more flexible for applications. Conclusion: The proposed single (qMTNet-1) and two joint neural networks (qMTNet-2) can accelerate qMT workflow for both data acquisition and fitting significantly. qMTNet has the potential to accelerate qMT imaging for clinical applications, which warrants further investigation.

Original languageEnglish
Pages (from-to)298-308
Number of pages11
JournalMagnetic Resonance in Medicine
Issue number1
StatePublished - 1 Jan 2021


  • acceleration
  • artificial neural network
  • deep learning
  • magnetization transfer
  • quantitative imaging

Fingerprint Dive into the research topics of 'qMTNet: Accelerated quantitative magnetization transfer imaging with artificial neural networks'. Together they form a unique fingerprint.

Cite this