Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers

Min Ji Kim, Misol Do, Dohyun Han, Minsoo Son, Dongyoon Shin, Injoon Yeo, Young Hyun Yun, Seong Ho Yoo, Hyung Jin Choi, Daun Shin, Sang Jin Rhee, Yong Min Ahn, Youngsoo Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Suicide is a leading cause of death worldwide, presenting a serious public health problem. We aimed to investigate the biological basis of suicide completion using proteomics on postmortem brain tissue. Thirty-six postmortem brain samples (23 suicide completers and 13 controls) were collected. We evaluated the proteomic profile in the prefrontal cortex (Broadmann area 9, 10) using tandem mass tag-based quantification with liquid chromatography–tandem mass spectrometry. Bioinformatics tools were used to elucidate the biological mechanisms related to suicide. Subgroup analysis was conducted to identify common differentially expressed proteins among clinically different groups. Of 9801 proteins identified, 295 were differentially expressed between groups. Suicide completion samples were mostly enriched in the endocannabinoid and apoptotic pathways (CAPNS1, CSNK2B, PTP4A2). Among the differentially expressed proteins, GSTT1 was identified as a potential biomarker among suicide completers with psychiatric disorders. Our findings suggest that the previously under-recognized endocannabinoid system and apoptotic processes are highly involved in suicide.

Original languageEnglish
Article number142
JournalTranslational psychiatry
Volume12
Issue number1
DOIs
StatePublished - Dec 2022

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