Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer

Jeong Il Yu, Hee Chul Park, Doo Ho Choi, Jae Myoung Noh, Dongryul Oh, Jun Su Park, Ji Hyun Chang, Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang

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4 Scopus citations

Abstract

Purpose: A prospective phase II trial was conducted to evaluate the effectiveness and toxicity of regional hyperthermia and whole liver irradiation (WLI) for numerous chemorefractory liver metastases from colorectal cancer. Materials and Methods: Enrolled patients had numerous chemorefractory hepatic metastases from colorectal cancer. Five sessions of hyperthermia and seven fractions of 3-gray WLI were planned. Health-related quality of life (HRQoL) was determined using the Korean version of the European Organization for Research and Treatment of Cancer quality of life questionnaire C-30 and the Functional Assessment of Cancer Therapy-Hepatobiliary version 4.0. Objective and pain response was evaluated. Results: A total of 12 patients consented to the study and the 10 who received WLI and hyperthermia were analyzed. WLI was completed as planned in nine patients and hyperthermia in eight. Pain response was partial in four patients and stable in four. Partial objective response was achieved in three patients (30.0%) and stable disease was seen in four patients at the 1-month follow-up. One patient died 1 month after treatment because of respiratory failure related to pleural metastasis progression. Other grade III or higher toxicities were detected in three patients; however, all severe toxicities were related to disease progression rather than treatment. No significant difference in HRQoL was noted at the time of assessment for patients who were available for questionnaires. Conclusion: Combined WLI and hyperthermia were well tolerated without severe treatment-related toxicity with a promising response from numerous chemorefractory hepatic metastases from colorectal cancer.

Original languageEnglish
Pages (from-to)34-44
Number of pages11
JournalRadiation Oncology Journal
Volume34
Issue number1
DOIs
StatePublished - Mar 2016

Keywords

  • Colorectal neoplasms
  • Induced hyperthermia
  • Pain
  • Quality of life
  • Radiotherapy

Cite this

Yu, J. I., Park, H. C., Choi, D. H., Noh, J. M., Oh, D., Park, J. S., Chang, J. H., Kim, S. T., Lee, J., Park, S. H., Park, J. O., Park, Y. S., Lim, H. Y., & Kang, W. K. (2016). Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer. Radiation Oncology Journal, 34(1), 34-44. https://doi.org/10.3857/roj.2016.34.1.34