Prospective Evaluation of Hepatic Steatosis Using Ultrasound Attenuation Imaging in Patients with Chronic Liver Disease with Magnetic Resonance Imaging Proton Density Fat Fraction as the Reference Standard

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Abstract

The purpose of our study was to investigate the diagnostic performance of 2-D ultrasound attenuation imaging (ATI)for the assessment of hepatic steatosis in patients with chronic liver disease using magnetic resonance imaging proton density fat fraction (MRI-PDFF)as the reference standard. We prospectively analyzed 87 patients with chronic liver disease who had reliable measurements at both ATI and MRI-PDFF. For the detection of hepatic steatosis of MRI-PDFF ≥5% and MRI-PDFF ≥10%, ATI measurements yielded areas under the receiver operating characteristic curve of 0.76 and 0.88, respectively (95% confidence intervals: 0.66–0.85 and 0.79–0.94). Attenuation coefficients at ATI were moderately correlated with MRI-PDFF (ρ = 0.66). In conclusion, attenuation coefficients at ultrasound ATI were well correlated with MRI-PDFF and, thus, may provide good diagnostic performance in the assessment of hepatic steatosis, making these coefficients a promising tool for the non-invasive assessment and quantification of hepatic steatosis.

Original languageEnglish
Pages (from-to)1407-1416
Number of pages10
JournalUltrasound in Medicine and Biology
Volume45
Issue number6
DOIs
StatePublished - Jun 2019

Keywords

  • Attenuation imaging
  • Chronic liver disease
  • Fat quantification
  • Hepatic steatosis
  • Proton density fat fraction
  • Ultrasound

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