Prospective cohort study of patients with early gastric cancer to detect prodromal Parkinson disease (EGC-PPD)

A study protocol and baseline characteristics

Chaewon Shin, Han-Kwang Yang, Sung-Hye Park, Hyuk-Joon Lee, Seong Ho Kong, Yun Suhk Suh, Yeon Ju Huh, Yun Jeong Kim, So Yong Park, Tae Beom Ahn, Seok Hwa Lee, Han-Joon Kim, Beomseok Jeon

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The aim of the current study is to determine the predictive value of alpha-synuclein (AS) aggregation in stomach surgical specimens in combination with selected clinical prodromal markers (CPMs) for development of Parkinson disease (PD) in a normal population. We organized a prospective, long-term, clinicopathologic cohort of patients without neurological diseases who received a radical operation for early gastric cancer (EGC) between ages 50 and 65 years. The participants will be followed for up to 10 years and screened for CPMs and motor symptoms by annual telephone interview. If a participant reports one or more positive answers to screening questions about motor symptoms, they will be regarded as having possible parkinsonism. A movement disorder specialist will then evaluate whether that participant has PD. The primary outcome is the development of PD during the 10-year follow-up. The recruitment period has been completed, and the baseline clinical characteristics are compared between participants with and without possible parkinsonism. A total of 718 participants (mean age: 60.1 ± 5.9) was recruited. The motor symptom screening questionnaire revealed 65 patients with possible parkinsonism (9.0%) at baseline. Patients with possible parkinsonism answered that they had subjective loss of smell more than those without parkinsonism at the time of recruitment (18.5% vs 8.3%) and operation (15.4% vs 6.3%). However, the objective odor discrimination test showed no difference between patients with and without possible parkinsonism. Baseline assessments revealed a sufficient number of patients with possible parkinsonism, which will be confirmed as PD or not in subsequent follow-up visits.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalJournal of Clinical Neuroscience
Volume66
DOIs
StatePublished - 1 Aug 2019

Fingerprint

Parkinsonian Disorders
Stomach Neoplasms
Parkinson Disease
Cohort Studies
Prospective Studies
Biomarkers
alpha-Synuclein
Smell
Movement Disorders
Stomach
Interviews
Population

Keywords

  • Alpha-synuclein
  • Cohort
  • Non-motor symptom
  • Observational
  • Parkinson disease
  • Prodromal
  • Prospective
  • Stomach

Cite this

@article{b9140110efaf459e88234a7ab16accec,
title = "Prospective cohort study of patients with early gastric cancer to detect prodromal Parkinson disease (EGC-PPD): A study protocol and baseline characteristics",
abstract = "The aim of the current study is to determine the predictive value of alpha-synuclein (AS) aggregation in stomach surgical specimens in combination with selected clinical prodromal markers (CPMs) for development of Parkinson disease (PD) in a normal population. We organized a prospective, long-term, clinicopathologic cohort of patients without neurological diseases who received a radical operation for early gastric cancer (EGC) between ages 50 and 65 years. The participants will be followed for up to 10 years and screened for CPMs and motor symptoms by annual telephone interview. If a participant reports one or more positive answers to screening questions about motor symptoms, they will be regarded as having possible parkinsonism. A movement disorder specialist will then evaluate whether that participant has PD. The primary outcome is the development of PD during the 10-year follow-up. The recruitment period has been completed, and the baseline clinical characteristics are compared between participants with and without possible parkinsonism. A total of 718 participants (mean age: 60.1 ± 5.9) was recruited. The motor symptom screening questionnaire revealed 65 patients with possible parkinsonism (9.0{\%}) at baseline. Patients with possible parkinsonism answered that they had subjective loss of smell more than those without parkinsonism at the time of recruitment (18.5{\%} vs 8.3{\%}) and operation (15.4{\%} vs 6.3{\%}). However, the objective odor discrimination test showed no difference between patients with and without possible parkinsonism. Baseline assessments revealed a sufficient number of patients with possible parkinsonism, which will be confirmed as PD or not in subsequent follow-up visits.",
keywords = "Alpha-synuclein, Cohort, Non-motor symptom, Observational, Parkinson disease, Prodromal, Prospective, Stomach",
author = "Chaewon Shin and Han-Kwang Yang and Sung-Hye Park and Hyuk-Joon Lee and Kong, {Seong Ho} and Suh, {Yun Suhk} and Huh, {Yeon Ju} and Kim, {Yun Jeong} and Park, {So Yong} and Ahn, {Tae Beom} and Lee, {Seok Hwa} and Han-Joon Kim and Beomseok Jeon",
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language = "English",
volume = "66",
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publisher = "Churchill Livingstone",

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Prospective cohort study of patients with early gastric cancer to detect prodromal Parkinson disease (EGC-PPD) : A study protocol and baseline characteristics. / Shin, Chaewon; Yang, Han-Kwang; Park, Sung-Hye; Lee, Hyuk-Joon; Kong, Seong Ho; Suh, Yun Suhk; Huh, Yeon Ju; Kim, Yun Jeong; Park, So Yong; Ahn, Tae Beom; Lee, Seok Hwa; Kim, Han-Joon; Jeon, Beomseok.

In: Journal of Clinical Neuroscience, Vol. 66, 01.08.2019, p. 26-32.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Prospective cohort study of patients with early gastric cancer to detect prodromal Parkinson disease (EGC-PPD)

T2 - A study protocol and baseline characteristics

AU - Shin, Chaewon

AU - Yang, Han-Kwang

AU - Park, Sung-Hye

AU - Lee, Hyuk-Joon

AU - Kong, Seong Ho

AU - Suh, Yun Suhk

AU - Huh, Yeon Ju

AU - Kim, Yun Jeong

AU - Park, So Yong

AU - Ahn, Tae Beom

AU - Lee, Seok Hwa

AU - Kim, Han-Joon

AU - Jeon, Beomseok

PY - 2019/8/1

Y1 - 2019/8/1

N2 - The aim of the current study is to determine the predictive value of alpha-synuclein (AS) aggregation in stomach surgical specimens in combination with selected clinical prodromal markers (CPMs) for development of Parkinson disease (PD) in a normal population. We organized a prospective, long-term, clinicopathologic cohort of patients without neurological diseases who received a radical operation for early gastric cancer (EGC) between ages 50 and 65 years. The participants will be followed for up to 10 years and screened for CPMs and motor symptoms by annual telephone interview. If a participant reports one or more positive answers to screening questions about motor symptoms, they will be regarded as having possible parkinsonism. A movement disorder specialist will then evaluate whether that participant has PD. The primary outcome is the development of PD during the 10-year follow-up. The recruitment period has been completed, and the baseline clinical characteristics are compared between participants with and without possible parkinsonism. A total of 718 participants (mean age: 60.1 ± 5.9) was recruited. The motor symptom screening questionnaire revealed 65 patients with possible parkinsonism (9.0%) at baseline. Patients with possible parkinsonism answered that they had subjective loss of smell more than those without parkinsonism at the time of recruitment (18.5% vs 8.3%) and operation (15.4% vs 6.3%). However, the objective odor discrimination test showed no difference between patients with and without possible parkinsonism. Baseline assessments revealed a sufficient number of patients with possible parkinsonism, which will be confirmed as PD or not in subsequent follow-up visits.

AB - The aim of the current study is to determine the predictive value of alpha-synuclein (AS) aggregation in stomach surgical specimens in combination with selected clinical prodromal markers (CPMs) for development of Parkinson disease (PD) in a normal population. We organized a prospective, long-term, clinicopathologic cohort of patients without neurological diseases who received a radical operation for early gastric cancer (EGC) between ages 50 and 65 years. The participants will be followed for up to 10 years and screened for CPMs and motor symptoms by annual telephone interview. If a participant reports one or more positive answers to screening questions about motor symptoms, they will be regarded as having possible parkinsonism. A movement disorder specialist will then evaluate whether that participant has PD. The primary outcome is the development of PD during the 10-year follow-up. The recruitment period has been completed, and the baseline clinical characteristics are compared between participants with and without possible parkinsonism. A total of 718 participants (mean age: 60.1 ± 5.9) was recruited. The motor symptom screening questionnaire revealed 65 patients with possible parkinsonism (9.0%) at baseline. Patients with possible parkinsonism answered that they had subjective loss of smell more than those without parkinsonism at the time of recruitment (18.5% vs 8.3%) and operation (15.4% vs 6.3%). However, the objective odor discrimination test showed no difference between patients with and without possible parkinsonism. Baseline assessments revealed a sufficient number of patients with possible parkinsonism, which will be confirmed as PD or not in subsequent follow-up visits.

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KW - Cohort

KW - Non-motor symptom

KW - Observational

KW - Parkinson disease

KW - Prodromal

KW - Prospective

KW - Stomach

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