Progression to gestational diabetes mellitus in pregnant women with one abnormal value in repeated oral glucose tolerance tests

Sunyoung Kang, Min Hyoung Kim, Moon Young Kim, Joon Seok Hong, Soo Heon Kwak, Sung Hee Choi, Soo Lim, Kyong Soo Park, Hak C. Jang

Research output: Contribution to journalArticle

Abstract

Background: Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. Methods: To identify clinical and metabolic predictors for GDM in women with OAV, we conducted a retrospective study and identified women with OAV in the OGTT done at 24 to 30 weeks gestational age (GA) and repeated the second OGTT between 32 and 34 weeks of GA. Results: Among 137 women with OAV in the initial OGTT, 58 (42.3%) had normal, 40 (29.2%) had OAV and 39 (28.5%) had GDM in the second OGTT. Maternal age, prepregnancy body mass index, weight gain from prepregnancy to the second OGTT, GA at the time of the OGTT, and parity were similar among normal, OAV, and GDM groups. Plasma glucose levels in screening tests were different (151.8±15.7, 155.8±14.6, 162.5±20.3 mg/dL, P<0.05), but fasting, 1-, 2-, and 3-hour glucose levels in the initial OGTT were not. Compared to women with screen negative, women with untreated OAV had a higher frequency of macrosomia. Conclusion: We demonstrated that women with OAV in the initial OGTT significantly progressed to GDM in the second OGTT. Clinical parameters predicting progression to GDM were not found. Repeating the OGTT in women with OAV in the initial test may be helpful to detect GDM progression.

Original languageEnglish
Pages (from-to)607-614
Number of pages8
JournalDiabetes and Metabolism Journal
Volume43
Issue number5
DOIs
StatePublished - 1 Jan 2019

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Gestational Diabetes
Glucose Tolerance Test
Pregnant Women
Gestational Age
Glucose
Maternal Age
Pregnancy Outcome
Parity
Weight Gain
Fasting
Body Mass Index
Retrospective Studies

Keywords

  • Diabetes gestational
  • Glucose tolerance test
  • Pregnancy outcome

Cite this

@article{09ea84dd4fd6446abe83b65d583a4957,
title = "Progression to gestational diabetes mellitus in pregnant women with one abnormal value in repeated oral glucose tolerance tests",
abstract = "Background: Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. Methods: To identify clinical and metabolic predictors for GDM in women with OAV, we conducted a retrospective study and identified women with OAV in the OGTT done at 24 to 30 weeks gestational age (GA) and repeated the second OGTT between 32 and 34 weeks of GA. Results: Among 137 women with OAV in the initial OGTT, 58 (42.3{\%}) had normal, 40 (29.2{\%}) had OAV and 39 (28.5{\%}) had GDM in the second OGTT. Maternal age, prepregnancy body mass index, weight gain from prepregnancy to the second OGTT, GA at the time of the OGTT, and parity were similar among normal, OAV, and GDM groups. Plasma glucose levels in screening tests were different (151.8±15.7, 155.8±14.6, 162.5±20.3 mg/dL, P<0.05), but fasting, 1-, 2-, and 3-hour glucose levels in the initial OGTT were not. Compared to women with screen negative, women with untreated OAV had a higher frequency of macrosomia. Conclusion: We demonstrated that women with OAV in the initial OGTT significantly progressed to GDM in the second OGTT. Clinical parameters predicting progression to GDM were not found. Repeating the OGTT in women with OAV in the initial test may be helpful to detect GDM progression.",
keywords = "Diabetes gestational, Glucose tolerance test, Pregnancy outcome",
author = "Sunyoung Kang and Kim, {Min Hyoung} and Kim, {Moon Young} and Hong, {Joon Seok} and Kwak, {Soo Heon} and Choi, {Sung Hee} and Soo Lim and Park, {Kyong Soo} and Jang, {Hak C.}",
year = "2019",
month = "1",
day = "1",
doi = "10.4093/dmj.2018.0159",
language = "English",
volume = "43",
pages = "607--614",
journal = "Diabetes and Metabolism Journal",
issn = "2233-6079",
publisher = "Korean Diabetes Association",
number = "5",

}

TY - JOUR

T1 - Progression to gestational diabetes mellitus in pregnant women with one abnormal value in repeated oral glucose tolerance tests

AU - Kang, Sunyoung

AU - Kim, Min Hyoung

AU - Kim, Moon Young

AU - Hong, Joon Seok

AU - Kwak, Soo Heon

AU - Choi, Sung Hee

AU - Lim, Soo

AU - Park, Kyong Soo

AU - Jang, Hak C.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. Methods: To identify clinical and metabolic predictors for GDM in women with OAV, we conducted a retrospective study and identified women with OAV in the OGTT done at 24 to 30 weeks gestational age (GA) and repeated the second OGTT between 32 and 34 weeks of GA. Results: Among 137 women with OAV in the initial OGTT, 58 (42.3%) had normal, 40 (29.2%) had OAV and 39 (28.5%) had GDM in the second OGTT. Maternal age, prepregnancy body mass index, weight gain from prepregnancy to the second OGTT, GA at the time of the OGTT, and parity were similar among normal, OAV, and GDM groups. Plasma glucose levels in screening tests were different (151.8±15.7, 155.8±14.6, 162.5±20.3 mg/dL, P<0.05), but fasting, 1-, 2-, and 3-hour glucose levels in the initial OGTT were not. Compared to women with screen negative, women with untreated OAV had a higher frequency of macrosomia. Conclusion: We demonstrated that women with OAV in the initial OGTT significantly progressed to GDM in the second OGTT. Clinical parameters predicting progression to GDM were not found. Repeating the OGTT in women with OAV in the initial test may be helpful to detect GDM progression.

AB - Background: Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated. Methods: To identify clinical and metabolic predictors for GDM in women with OAV, we conducted a retrospective study and identified women with OAV in the OGTT done at 24 to 30 weeks gestational age (GA) and repeated the second OGTT between 32 and 34 weeks of GA. Results: Among 137 women with OAV in the initial OGTT, 58 (42.3%) had normal, 40 (29.2%) had OAV and 39 (28.5%) had GDM in the second OGTT. Maternal age, prepregnancy body mass index, weight gain from prepregnancy to the second OGTT, GA at the time of the OGTT, and parity were similar among normal, OAV, and GDM groups. Plasma glucose levels in screening tests were different (151.8±15.7, 155.8±14.6, 162.5±20.3 mg/dL, P<0.05), but fasting, 1-, 2-, and 3-hour glucose levels in the initial OGTT were not. Compared to women with screen negative, women with untreated OAV had a higher frequency of macrosomia. Conclusion: We demonstrated that women with OAV in the initial OGTT significantly progressed to GDM in the second OGTT. Clinical parameters predicting progression to GDM were not found. Repeating the OGTT in women with OAV in the initial test may be helpful to detect GDM progression.

KW - Diabetes gestational

KW - Glucose tolerance test

KW - Pregnancy outcome

UR - http://www.scopus.com/inward/record.url?scp=85075177259&partnerID=8YFLogxK

U2 - 10.4093/dmj.2018.0159

DO - 10.4093/dmj.2018.0159

M3 - Article

AN - SCOPUS:85075177259

VL - 43

SP - 607

EP - 614

JO - Diabetes and Metabolism Journal

JF - Diabetes and Metabolism Journal

SN - 2233-6079

IS - 5

ER -