Progression of Oropharyngeal Dysphagia in Patients with Multiple System Atrophy

Hui Jae Do, Han Gil Seo, Hyun Haeng Lee, Byung Mo Oh, Yoon Kim, Aryun Kim, Han Joon Kim, Beomseok Jeon, Tai Ryoon Han

Research output: Contribution to journalArticle

Abstract

We investigated the progression of oropharyngeal dysphagia in patients with multiple system atrophy (MSA), with particular emphasis on MSA subtype variation. Fifty-nine MSA patients (31 MSA-P, 21 MSA-C, and 7 MSA-PC) who had undergone at least one videofluoroscopic swallowing study (VFSS) to evaluate dysphagia symptoms were included. Clinical data and VFSS findings were retrospectively evaluated using the videofluoroscopic dysphagia scale (VDS), and the results of each MSA subtype group were compared. The median latency to onset of diet modification from onset of MSA symptoms was 5.995 (95% CI 4.890–7.099) years in all MSA patients, 5.036 (95% CI 3.605–6.467) years in MSA-P, and 6.800 (95% CI 6.078–7.522) years in MSA-C (P = 0.035). The latency to onset of diet modification from onset of dysphagia symptoms was 2.715 (95% CI 2.132–3.298) years in all MSA patients, 2.299 (95% CI 1.194–3.403) years in MSA-P, and 5.074 (95% CI 2.565–7.583) years in MSA-C (P = 0.039). The latencies to onset of tube feeding from onset of MSA symptoms and dysphagia symptoms were 7.003 (95% CI 6.738–7.268) years and 3.515 (95% CI 2.123–4.907) years, respectively, in all MSA patients, without significant difference between subtypes. In the patients who underwent VFSS follow-up for ≥ 1 year, 6 oral VDS items significantly worsened; only two pharyngeal items exhibited significant changes. Patients with MSA-P commenced diet modification earlier than patients with MSA-C, despite no significant difference in the latency to onset of tube feeding. Deterioration of dysphagia may be more pronounced in the oral function of MSA patients.

Original languageEnglish
Pages (from-to)24-31
Number of pages8
JournalDysphagia
Volume35
Issue number1
DOIs
StatePublished - 1 Feb 2020

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Multiple System Atrophy
Deglutition Disorders
Diet Therapy
Deglutition
Enteral Nutrition

Keywords

  • Deglutition
  • Deglutition disorders
  • Dysphagia
  • Multiple system atrophy
  • Neurodegenerative diseases

Cite this

Do, Hui Jae ; Seo, Han Gil ; Lee, Hyun Haeng ; Oh, Byung Mo ; Kim, Yoon ; Kim, Aryun ; Kim, Han Joon ; Jeon, Beomseok ; Han, Tai Ryoon. / Progression of Oropharyngeal Dysphagia in Patients with Multiple System Atrophy. In: Dysphagia. 2020 ; Vol. 35, No. 1. pp. 24-31.
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Progression of Oropharyngeal Dysphagia in Patients with Multiple System Atrophy. / Do, Hui Jae; Seo, Han Gil; Lee, Hyun Haeng; Oh, Byung Mo; Kim, Yoon; Kim, Aryun; Kim, Han Joon; Jeon, Beomseok; Han, Tai Ryoon.

In: Dysphagia, Vol. 35, No. 1, 01.02.2020, p. 24-31.

Research output: Contribution to journalArticle

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T1 - Progression of Oropharyngeal Dysphagia in Patients with Multiple System Atrophy

AU - Do, Hui Jae

AU - Seo, Han Gil

AU - Lee, Hyun Haeng

AU - Oh, Byung Mo

AU - Kim, Yoon

AU - Kim, Aryun

AU - Kim, Han Joon

AU - Jeon, Beomseok

AU - Han, Tai Ryoon

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AB - We investigated the progression of oropharyngeal dysphagia in patients with multiple system atrophy (MSA), with particular emphasis on MSA subtype variation. Fifty-nine MSA patients (31 MSA-P, 21 MSA-C, and 7 MSA-PC) who had undergone at least one videofluoroscopic swallowing study (VFSS) to evaluate dysphagia symptoms were included. Clinical data and VFSS findings were retrospectively evaluated using the videofluoroscopic dysphagia scale (VDS), and the results of each MSA subtype group were compared. The median latency to onset of diet modification from onset of MSA symptoms was 5.995 (95% CI 4.890–7.099) years in all MSA patients, 5.036 (95% CI 3.605–6.467) years in MSA-P, and 6.800 (95% CI 6.078–7.522) years in MSA-C (P = 0.035). The latency to onset of diet modification from onset of dysphagia symptoms was 2.715 (95% CI 2.132–3.298) years in all MSA patients, 2.299 (95% CI 1.194–3.403) years in MSA-P, and 5.074 (95% CI 2.565–7.583) years in MSA-C (P = 0.039). The latencies to onset of tube feeding from onset of MSA symptoms and dysphagia symptoms were 7.003 (95% CI 6.738–7.268) years and 3.515 (95% CI 2.123–4.907) years, respectively, in all MSA patients, without significant difference between subtypes. In the patients who underwent VFSS follow-up for ≥ 1 year, 6 oral VDS items significantly worsened; only two pharyngeal items exhibited significant changes. Patients with MSA-P commenced diet modification earlier than patients with MSA-C, despite no significant difference in the latency to onset of tube feeding. Deterioration of dysphagia may be more pronounced in the oral function of MSA patients.

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