Prognostication in Patients Treated with Radical Cystectomy for Urothelial Bladder Carcinoma: A New Simplified Model Incorporating Histological Variants

Ja Hyeon Ku, Hyeong Dong Yuk, Guiherme Godoy, Gilard E. Amiel, Seth P. Lerner

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: The aim of this study was to evaluate the clinical significance of histological variants (HV) and to develop a new and simple prediction model incorporating variant forms in patients who underwent radical cystectomy for urothelial carcinoma (UC). Materials and methods: We analyzed the data of 365 patients. We evaluated whether HV were independent predictors of survival. A new scoring model was developed using the regression coefficients from the multivariate Cox proportional hazard model. The patients were divided into three groups on the basis of the score: low-, intermediate-and high-risk. To evaluate the performance of the model, we assessed models in terms of discrimination and calibration. Results: Patients(median age; 68.5 years) with pure form and squamous differentiation did not differ significantly but statistical analysis of the survival curves of patients with pure form and other variants revealed a statistically significant difference in terms of cancer-specific survival (CSS) (p = 0.005) and overall survival (OS) (p = 0.010). According to the new scoring model HV, the 5-yr CSS rate in each group was 93.3%, 82.9% and 50.5%, respectively. The 5-yr OS rate in each group was 90.0%, 66.3% and 33.2%, respectively. Model discrimination was good for all year models. Calibration was also adequate for the model in all year models. Conclusions: HV were found to be important independent prognostic factors in urothelial bladder cancer. This paper presents a new prognostic model incorporating variant forms for predicting CSS and OS in these patients.

Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalBladder Cancer
Volume4
Issue number2
DOIs
StatePublished - 1 Jan 2018

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Cystectomy
Urinary Bladder
Carcinoma
Survival
Calibration
Survival Rate
Neoplasms
Survival Analysis
Proportional Hazards Models
Urinary Bladder Neoplasms

Keywords

  • Bladder cancer
  • cystectomy
  • outcomes
  • urothelial carcinoma
  • variant histology

Cite this

@article{5bb00b931bec448483b5f0457bcfc7b6,
title = "Prognostication in Patients Treated with Radical Cystectomy for Urothelial Bladder Carcinoma: A New Simplified Model Incorporating Histological Variants",
abstract = "Purpose: The aim of this study was to evaluate the clinical significance of histological variants (HV) and to develop a new and simple prediction model incorporating variant forms in patients who underwent radical cystectomy for urothelial carcinoma (UC). Materials and methods: We analyzed the data of 365 patients. We evaluated whether HV were independent predictors of survival. A new scoring model was developed using the regression coefficients from the multivariate Cox proportional hazard model. The patients were divided into three groups on the basis of the score: low-, intermediate-and high-risk. To evaluate the performance of the model, we assessed models in terms of discrimination and calibration. Results: Patients(median age; 68.5 years) with pure form and squamous differentiation did not differ significantly but statistical analysis of the survival curves of patients with pure form and other variants revealed a statistically significant difference in terms of cancer-specific survival (CSS) (p = 0.005) and overall survival (OS) (p = 0.010). According to the new scoring model HV, the 5-yr CSS rate in each group was 93.3{\%}, 82.9{\%} and 50.5{\%}, respectively. The 5-yr OS rate in each group was 90.0{\%}, 66.3{\%} and 33.2{\%}, respectively. Model discrimination was good for all year models. Calibration was also adequate for the model in all year models. Conclusions: HV were found to be important independent prognostic factors in urothelial bladder cancer. This paper presents a new prognostic model incorporating variant forms for predicting CSS and OS in these patients.",
keywords = "Bladder cancer, cystectomy, outcomes, urothelial carcinoma, variant histology",
author = "Ku, {Ja Hyeon} and Yuk, {Hyeong Dong} and Guiherme Godoy and Amiel, {Gilard E.} and Lerner, {Seth P.}",
year = "2018",
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day = "1",
doi = "10.3233/BLC-170156",
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Prognostication in Patients Treated with Radical Cystectomy for Urothelial Bladder Carcinoma : A New Simplified Model Incorporating Histological Variants. / Ku, Ja Hyeon; Yuk, Hyeong Dong; Godoy, Guiherme; Amiel, Gilard E.; Lerner, Seth P.

In: Bladder Cancer, Vol. 4, No. 2, 01.01.2018, p. 195-203.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostication in Patients Treated with Radical Cystectomy for Urothelial Bladder Carcinoma

T2 - A New Simplified Model Incorporating Histological Variants

AU - Ku, Ja Hyeon

AU - Yuk, Hyeong Dong

AU - Godoy, Guiherme

AU - Amiel, Gilard E.

AU - Lerner, Seth P.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: The aim of this study was to evaluate the clinical significance of histological variants (HV) and to develop a new and simple prediction model incorporating variant forms in patients who underwent radical cystectomy for urothelial carcinoma (UC). Materials and methods: We analyzed the data of 365 patients. We evaluated whether HV were independent predictors of survival. A new scoring model was developed using the regression coefficients from the multivariate Cox proportional hazard model. The patients were divided into three groups on the basis of the score: low-, intermediate-and high-risk. To evaluate the performance of the model, we assessed models in terms of discrimination and calibration. Results: Patients(median age; 68.5 years) with pure form and squamous differentiation did not differ significantly but statistical analysis of the survival curves of patients with pure form and other variants revealed a statistically significant difference in terms of cancer-specific survival (CSS) (p = 0.005) and overall survival (OS) (p = 0.010). According to the new scoring model HV, the 5-yr CSS rate in each group was 93.3%, 82.9% and 50.5%, respectively. The 5-yr OS rate in each group was 90.0%, 66.3% and 33.2%, respectively. Model discrimination was good for all year models. Calibration was also adequate for the model in all year models. Conclusions: HV were found to be important independent prognostic factors in urothelial bladder cancer. This paper presents a new prognostic model incorporating variant forms for predicting CSS and OS in these patients.

AB - Purpose: The aim of this study was to evaluate the clinical significance of histological variants (HV) and to develop a new and simple prediction model incorporating variant forms in patients who underwent radical cystectomy for urothelial carcinoma (UC). Materials and methods: We analyzed the data of 365 patients. We evaluated whether HV were independent predictors of survival. A new scoring model was developed using the regression coefficients from the multivariate Cox proportional hazard model. The patients were divided into three groups on the basis of the score: low-, intermediate-and high-risk. To evaluate the performance of the model, we assessed models in terms of discrimination and calibration. Results: Patients(median age; 68.5 years) with pure form and squamous differentiation did not differ significantly but statistical analysis of the survival curves of patients with pure form and other variants revealed a statistically significant difference in terms of cancer-specific survival (CSS) (p = 0.005) and overall survival (OS) (p = 0.010). According to the new scoring model HV, the 5-yr CSS rate in each group was 93.3%, 82.9% and 50.5%, respectively. The 5-yr OS rate in each group was 90.0%, 66.3% and 33.2%, respectively. Model discrimination was good for all year models. Calibration was also adequate for the model in all year models. Conclusions: HV were found to be important independent prognostic factors in urothelial bladder cancer. This paper presents a new prognostic model incorporating variant forms for predicting CSS and OS in these patients.

KW - Bladder cancer

KW - cystectomy

KW - outcomes

KW - urothelial carcinoma

KW - variant histology

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DO - 10.3233/BLC-170156

M3 - Article

AN - SCOPUS:85050941829

VL - 4

SP - 195

EP - 203

JO - Bladder Cancer

JF - Bladder Cancer

SN - 2352-3727

IS - 2

ER -