Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemoradiation therapy

Jeong Il Yu, Hyebin Lee, Hee Chul Park, Doo Ho Choi, Yoon La Choi, In Gu Do, Hee Cheol Kim, Woo Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Young Suk Park, Joon Oh Park, Seung Tae Kim, Won Park

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3 Scopus citations

Abstract

Background & Aims: This study is designed to investigate the expression of survivin and p53 in human rectal cancer tissues and analyze associations between expression and clinical outcomes in terms of disease recurrence and survival duration. Results: During follow-up (median 119.0, range 6.6 to 161.3 months), tumor recurrence was detected in 50 patients (43.1%), and local recurrence developed as a first failure site in 13 patients (11.2%). Positive immunostaining of nuclear and cytoplasmic survivin was observed in about one quarter of patients, and about half of all patients had positive staining for p53. Both survivin and p53 were significant prognostic factors of disease-free survival in the univariate analyses, but only survivin remained a significant prognostic factor in the multivariate analysis. Methods: We performed a retrospective study with 116 locally advanced rectal cancer patients who underwent total mesorectal excision (TME) followed by postoperative concurrent chemo-radiation therapy (CCRT). Immunohistochemical staining was conducted using antibodies for survivin or p53, and their expression was analyzed using an individual score that combined the percentage of positive cells and staining intensity. Conclusions: Overexpression of nuclear and cytoplasmic survivin in locally advanced rectal cancer patients was associated with a higher recurrence rate in rectal cancer patients treated with TME followed by postoperative CCRT.

Original languageEnglish
Pages (from-to)62676-62686
Number of pages11
JournalOncotarget
Volume7
Issue number38
DOIs
StatePublished - 1 Jan 2016
Externally publishedYes

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Keywords

  • Prognosis
  • Radiotherapy
  • Rectal neoplasm
  • Survivin
  • Total mesorectal excision

Cite this

Yu, J. I., Lee, H., Park, H. C., Choi, D. H., Choi, Y. L., Do, I. G., Kim, H. C., Lee, W. Y., Yun, S. H., Cho, Y. B., Huh, J. W., Park, Y. A., Park, Y. S., Park, J. O., Kim, S. T., & Park, W. (2016). Prognostic significance of survivin in rectal cancer patients treated with surgery and postoperative concurrent chemoradiation therapy. Oncotarget, 7(38), 62676-62686. https://doi.org/10.18632/oncotarget.10445