Prognostic role of body mass index is different according to menopausal status and tumor subtype in breast cancer patients

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Abstract

Purpose: Although controversial, obesity and underweight may have a negative impact on breast cancer outcome. However, the relationship between body mass index (BMI) and breast cancer outcomes according to tumor subtype and menopausal status remains unclear. Methods: This study investigated the association between BMI and breast cancer outcome in stage I–III breast cancer patients. The relationships were further evaluated according to tumor subtype and menopausal status. Results: A total of 5919 patients, 3475 (58.7%) hormone receptor (HR)(+) human epidermal growth factor receptor 2 (HER2)(–), 608 (10.3%) HR(+)HER2(+), 621 (10.5%) HR(–)HER2(+), and 1079 (18.2%) HR(–)HER2(–) were included. Underweight and obesity had a negative impact on relapse-free survival but did not affect overall survival. Importantly, the prognostic role of BMI was different according to tumor subtype and menopausal status. In HR(+)HER2(–) patients, underweight was associated with poor relapse-free survival and overall survival in pre-menopausal women. In contrast, obesity had negative impact on relapse-free survival and overall survival in HR(+)HER2(–) post-menopausal patients. Underweight may have a negative prognostic role in HR(+)HER2(+) patients. However, BMI did not impact the outcome of HR(–)HER2(+) and HR(–)HER2(–) patients. Conclusions: The impact of BMI on breast cancer outcome was dependent on tumor subtype and menopausal status. In HR(+)HER2(–) patients, underweight and obesity had a negative prognostic role in pre-menopausal and post-menopausal women, respectively. These findings in Asian population should be further evaluated and compared in Western population.

Original languageEnglish
Pages (from-to)453-460
Number of pages8
JournalBreast Cancer Research and Treatment
Volume176
Issue number2
DOIs
StatePublished - 30 Jul 2019

Fingerprint

Body Mass Index
Hormones
Breast Neoplasms
Thinness
Neoplasms
Survival
Obesity
Recurrence
human ERBB2 protein
Population

Keywords

  • Body mass index
  • Breast cancer
  • Menopausal status
  • Tumor subtype

Cite this

@article{61a825ea414d4355aca4dc6f35480c32,
title = "Prognostic role of body mass index is different according to menopausal status and tumor subtype in breast cancer patients",
abstract = "Purpose: Although controversial, obesity and underweight may have a negative impact on breast cancer outcome. However, the relationship between body mass index (BMI) and breast cancer outcomes according to tumor subtype and menopausal status remains unclear. Methods: This study investigated the association between BMI and breast cancer outcome in stage I–III breast cancer patients. The relationships were further evaluated according to tumor subtype and menopausal status. Results: A total of 5919 patients, 3475 (58.7{\%}) hormone receptor (HR)(+) human epidermal growth factor receptor 2 (HER2)(–), 608 (10.3{\%}) HR(+)HER2(+), 621 (10.5{\%}) HR(–)HER2(+), and 1079 (18.2{\%}) HR(–)HER2(–) were included. Underweight and obesity had a negative impact on relapse-free survival but did not affect overall survival. Importantly, the prognostic role of BMI was different according to tumor subtype and menopausal status. In HR(+)HER2(–) patients, underweight was associated with poor relapse-free survival and overall survival in pre-menopausal women. In contrast, obesity had negative impact on relapse-free survival and overall survival in HR(+)HER2(–) post-menopausal patients. Underweight may have a negative prognostic role in HR(+)HER2(+) patients. However, BMI did not impact the outcome of HR(–)HER2(+) and HR(–)HER2(–) patients. Conclusions: The impact of BMI on breast cancer outcome was dependent on tumor subtype and menopausal status. In HR(+)HER2(–) patients, underweight and obesity had a negative prognostic role in pre-menopausal and post-menopausal women, respectively. These findings in Asian population should be further evaluated and compared in Western population.",
keywords = "Body mass index, Breast cancer, Menopausal status, Tumor subtype",
author = "Kim, {Jung Youn} and Lee, {Dae Won} and Kyung-Hun Lee and Ahrum Min and Ryu, {Han Suk} and Han-Byoel Lee and Moon, {Hyeong Gon} and Tae-Yong Kim and Sae-Won Han and Do-Youn Oh and Wonshik Han and Inae Park and Dongyoung Noh and Seock-Ah Im and Sukil Kim",
year = "2019",
month = "7",
day = "30",
doi = "10.1007/s10549-019-05249-1",
language = "English",
volume = "176",
pages = "453--460",
journal = "Breast cancer research and treatment",
issn = "0167-6806",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Prognostic role of body mass index is different according to menopausal status and tumor subtype in breast cancer patients

AU - Kim, Jung Youn

AU - Lee, Dae Won

AU - Lee, Kyung-Hun

AU - Min, Ahrum

AU - Ryu, Han Suk

AU - Lee, Han-Byoel

AU - Moon, Hyeong Gon

AU - Kim, Tae-Yong

AU - Han, Sae-Won

AU - Oh, Do-Youn

AU - Han, Wonshik

AU - Park, Inae

AU - Noh, Dongyoung

AU - Im, Seock-Ah

AU - Kim, Sukil

PY - 2019/7/30

Y1 - 2019/7/30

N2 - Purpose: Although controversial, obesity and underweight may have a negative impact on breast cancer outcome. However, the relationship between body mass index (BMI) and breast cancer outcomes according to tumor subtype and menopausal status remains unclear. Methods: This study investigated the association between BMI and breast cancer outcome in stage I–III breast cancer patients. The relationships were further evaluated according to tumor subtype and menopausal status. Results: A total of 5919 patients, 3475 (58.7%) hormone receptor (HR)(+) human epidermal growth factor receptor 2 (HER2)(–), 608 (10.3%) HR(+)HER2(+), 621 (10.5%) HR(–)HER2(+), and 1079 (18.2%) HR(–)HER2(–) were included. Underweight and obesity had a negative impact on relapse-free survival but did not affect overall survival. Importantly, the prognostic role of BMI was different according to tumor subtype and menopausal status. In HR(+)HER2(–) patients, underweight was associated with poor relapse-free survival and overall survival in pre-menopausal women. In contrast, obesity had negative impact on relapse-free survival and overall survival in HR(+)HER2(–) post-menopausal patients. Underweight may have a negative prognostic role in HR(+)HER2(+) patients. However, BMI did not impact the outcome of HR(–)HER2(+) and HR(–)HER2(–) patients. Conclusions: The impact of BMI on breast cancer outcome was dependent on tumor subtype and menopausal status. In HR(+)HER2(–) patients, underweight and obesity had a negative prognostic role in pre-menopausal and post-menopausal women, respectively. These findings in Asian population should be further evaluated and compared in Western population.

AB - Purpose: Although controversial, obesity and underweight may have a negative impact on breast cancer outcome. However, the relationship between body mass index (BMI) and breast cancer outcomes according to tumor subtype and menopausal status remains unclear. Methods: This study investigated the association between BMI and breast cancer outcome in stage I–III breast cancer patients. The relationships were further evaluated according to tumor subtype and menopausal status. Results: A total of 5919 patients, 3475 (58.7%) hormone receptor (HR)(+) human epidermal growth factor receptor 2 (HER2)(–), 608 (10.3%) HR(+)HER2(+), 621 (10.5%) HR(–)HER2(+), and 1079 (18.2%) HR(–)HER2(–) were included. Underweight and obesity had a negative impact on relapse-free survival but did not affect overall survival. Importantly, the prognostic role of BMI was different according to tumor subtype and menopausal status. In HR(+)HER2(–) patients, underweight was associated with poor relapse-free survival and overall survival in pre-menopausal women. In contrast, obesity had negative impact on relapse-free survival and overall survival in HR(+)HER2(–) post-menopausal patients. Underweight may have a negative prognostic role in HR(+)HER2(+) patients. However, BMI did not impact the outcome of HR(–)HER2(+) and HR(–)HER2(–) patients. Conclusions: The impact of BMI on breast cancer outcome was dependent on tumor subtype and menopausal status. In HR(+)HER2(–) patients, underweight and obesity had a negative prognostic role in pre-menopausal and post-menopausal women, respectively. These findings in Asian population should be further evaluated and compared in Western population.

KW - Body mass index

KW - Breast cancer

KW - Menopausal status

KW - Tumor subtype

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U2 - 10.1007/s10549-019-05249-1

DO - 10.1007/s10549-019-05249-1

M3 - Article

VL - 176

SP - 453

EP - 460

JO - Breast cancer research and treatment

JF - Breast cancer research and treatment

SN - 0167-6806

IS - 2

ER -