Probiotic treatment induced change of inflammation related metabolites in IBS-D patients/double-blind, randomized, placebo-controlled trial

Jinjoo Kim, Kumsun Cho, Joo Sung Kim, Hyun Chae Jung, Bumsik Kim, Myeong Soo Park, Geun Eog Ji, Joo Youn Cho, Kyoung Sup Hong

Research output: Contribution to journalArticle

Abstract

There have been many studies suggesting that probiotics are effective in patients with diarrhea-predominant irritable bowel syndrome (IBS-D). However, its mechanism of action as well as prediction of response is still to be elucidated. In the present study, to find out metabolomic characteristics of probiotic effect in IBS-D, we compared IBS symptom changes and metabolomic characteristics in the subjects’ urine samples between multi-strain probiotics (one strain of Lactobacillus sp. and four strains of Bifidobacterium sp.) group (n = 32) and placebo group (n = 31). After 8 weeks’ administration (3 times/day), dissatisfaction in bowel habits and stool frequencies were significantly improved. Also, probiotics group had significantly changed seven metabolites including palmitic acid methyl ester (PAME) and 4,6-dihydroxyquinoline, 4-(2-aminophenyl)-2,4-dioxobutanoic acid (DOBA). According to IBS-SSS and IBS-QoL questionnaires, IBS-SSS responders showed higher PAME levels and IBS-QoL responders showed lower DOBA levels. This suggests potential role of these metabolites as a biomarker to predict probiotics effect in IBS-D patients.

Original languageEnglish
Pages (from-to)837-844
Number of pages8
JournalFood Science and Biotechnology
Volume29
Issue number6
DOIs
StatePublished - 1 Jun 2020

Keywords

  • Irritable bowel syndrome
  • Metabolomics
  • Probiotics

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