Primary systemic anaplastic large cell lymphoma in a single Korean institution: Clinical characteristics and treatment outcome

Ryun Park Sook, Yeon Baek Ji, Dong-Wan Kim, Seock-Ah Im, Taeyou Kim, Yung Jue Bang, Kyeong Kim Noe, Kyung Jeon Yoon, Woo Kim Chul, Dae Seog Heo

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Despite advances in the characterization of anaplastic large cell lymphoma (ALCL), little data is available on Asian patients. We report here upon single Korean institution's experience regarding the clinical characteristics and outcomes of ALCL. We performed a retrospective study of 32 adults with ALCL. Most of the patients received anthracycline-based chemotherapy. Ann Arbor stage III-IV, B symptoms, high-intermediate/ high International Prognostic Index (IPI), and extranodal disease at diagnosis were present in 56%, 44%, 41%, and 63%, respectively. Compared with Western studies, the male/female ratio (4.3) was markedly higher and skin (9%) and bone involvement (9%) were less frequent. The staining results for anaplastic lymphoma kinase were positive in 6 (33%) of 18 cases available. The complete response (CR) rate was 62% (95% CI, 44-80%). With a median follow-up of 51.0 months, 5 yr overall survival was 40±11%. The 3 yr relapse-free survival for the 18 patients who achieved CR was 74±12%. Age, performance status, lactate dehydrogenase, extranodal disease sites number, and IPI were correlated with treatment response and survival. Our data suggest that Korean ALCL patients appear to have a higher male/female ratio, less frequent skin/bone involvement, and lower CR rate compared with those of Western studies.

Original languageEnglish
Pages (from-to)633-638
Number of pages6
JournalJournal of Korean Medical Science
Issue number4
StatePublished - 2006


  • Anaplastic lymphoma kinase
  • CD30-Positive Anaplastic Large-Cell Lymphoma
  • Drug therapy
  • Lymphoma, Large Cell, Ki-1

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