Abstract
Background: Antimicrobial resistance of Helicobacter pylori (H pylori) affects the efficacy of eradication therapy. The aim of this study was to estimate the prevalence of primary and secondary resistance of H pylori isolates to antibiotics in Korea. Methods: The present study was performed from 2003 to 2018. Primary resistance was evaluated in 591 patients without any history of eradication and secondary resistance in 149 patients from whom Helicobacter pylori was cultured after failure of eradication. A minimal inhibitory concentration test was performed for amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin, and rifabutin using the agar dilution method. Results: An increase in the primary resistance rate was found in clarithromycin (P <.001), metronidazole (P <.001), and both levofloxacin (P <.001) during the study period. The primary resistance rates of amoxicillin and tetracycline were low and stable during the study period. The secondary resistance rate significantly increased in metronidazole and levofloxacin (P =.022 and.039, respectively). Conclusions: The primary and secondary resistance rates of clarithromycin, metronidazole, and levofloxacin for Helicobacter pylori in Korea were high and increased over time. However, the primary and secondary resistance rates of amoxicillin and tetracycline were low and stable over time. These results will help in selecting effective eradication regimens of H pylori in Korea in the future.
| Original language | English |
|---|---|
| Article number | e12660 |
| Journal | Helicobacter |
| Volume | 24 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1 Dec 2019 |
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Keywords
- Helicobacter pylori
- antibiotics
- prevalence
- resistance
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Primary and secondary antibiotic resistance of Helicobacter pylori in Korea from 2003 to 2018. / Lee, Ju Yup; Kim, Nayoung; Nam, Ryoung Hee; In Choi, Soo; Lee, Jung Won; Lee, Dong Ho.
In: Helicobacter, Vol. 24, No. 6, e12660, 01.12.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Primary and secondary antibiotic resistance of Helicobacter pylori in Korea from 2003 to 2018
AU - Lee, Ju Yup
AU - Kim, Nayoung
AU - Nam, Ryoung Hee
AU - In Choi, Soo
AU - Lee, Jung Won
AU - Lee, Dong Ho
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Background: Antimicrobial resistance of Helicobacter pylori (H pylori) affects the efficacy of eradication therapy. The aim of this study was to estimate the prevalence of primary and secondary resistance of H pylori isolates to antibiotics in Korea. Methods: The present study was performed from 2003 to 2018. Primary resistance was evaluated in 591 patients without any history of eradication and secondary resistance in 149 patients from whom Helicobacter pylori was cultured after failure of eradication. A minimal inhibitory concentration test was performed for amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin, and rifabutin using the agar dilution method. Results: An increase in the primary resistance rate was found in clarithromycin (P <.001), metronidazole (P <.001), and both levofloxacin (P <.001) during the study period. The primary resistance rates of amoxicillin and tetracycline were low and stable during the study period. The secondary resistance rate significantly increased in metronidazole and levofloxacin (P =.022 and.039, respectively). Conclusions: The primary and secondary resistance rates of clarithromycin, metronidazole, and levofloxacin for Helicobacter pylori in Korea were high and increased over time. However, the primary and secondary resistance rates of amoxicillin and tetracycline were low and stable over time. These results will help in selecting effective eradication regimens of H pylori in Korea in the future.
AB - Background: Antimicrobial resistance of Helicobacter pylori (H pylori) affects the efficacy of eradication therapy. The aim of this study was to estimate the prevalence of primary and secondary resistance of H pylori isolates to antibiotics in Korea. Methods: The present study was performed from 2003 to 2018. Primary resistance was evaluated in 591 patients without any history of eradication and secondary resistance in 149 patients from whom Helicobacter pylori was cultured after failure of eradication. A minimal inhibitory concentration test was performed for amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin, and rifabutin using the agar dilution method. Results: An increase in the primary resistance rate was found in clarithromycin (P <.001), metronidazole (P <.001), and both levofloxacin (P <.001) during the study period. The primary resistance rates of amoxicillin and tetracycline were low and stable during the study period. The secondary resistance rate significantly increased in metronidazole and levofloxacin (P =.022 and.039, respectively). Conclusions: The primary and secondary resistance rates of clarithromycin, metronidazole, and levofloxacin for Helicobacter pylori in Korea were high and increased over time. However, the primary and secondary resistance rates of amoxicillin and tetracycline were low and stable over time. These results will help in selecting effective eradication regimens of H pylori in Korea in the future.
KW - Helicobacter pylori
KW - antibiotics
KW - prevalence
KW - resistance
UR - http://www.scopus.com/inward/record.url?scp=85072165736&partnerID=8YFLogxK
U2 - 10.1111/hel.12660
DO - 10.1111/hel.12660
M3 - Article
C2 - 31507036
AN - SCOPUS:85072165736
VL - 24
JO - Helicobacter
JF - Helicobacter
SN - 1083-4389
IS - 6
M1 - e12660
ER -