Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study)

Seong Hwan Kim, Chol Shin, Sunwon Kim, Jin Seok Kim, Sang Yup Lim, Hyeong Seok Seo, Hong Euy Lim, Ki Chul Sung, Goo Yeong Cho, Seung Ku Lee, Yong Hyun Kim

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Apart from nondippers’ impact on cardiovascular events, the prevalence of isolated nocturnal hypertension (INH) and its consequences on both the heart and brain were not clearly investigated in the general population. METHODS AND RESULTS: The participants underwent ambulatory blood pressure monitoring evaluations for arterial stiffness, echocardiography, and brain magnetic resonance imaging. They were grouped into normotension, INH, and overt diurnal hy-pertension, based on ambulatory blood pressure monitoring and history of antihypertensive treatment. White matter hyperin-tensity, arterial stiffness, and echocardiographic parameters were compared. Of the 1734 participants, there were 475 (27.4%) subjects with normotension, 314 with INH (18.1%), and 945 with overt diurnal hypertension (54.5%). Prevalence of INH was not different between sex or age. Of INH, 71.3% (n=224) was caused by elevated diastolic blood pressure. After multivariable ad-justment, INH showed higher pulse wave velocity (P<0.001) and central systolic blood pressure (P<0.001), left ventricular mass index (P=0.026), and worse left ventricular diastolic function (early diastolic mitral annular velocity) (P<0.001) than normoten-sion. Mean white matter hyperintensity scores of INH were not different from normotension (P=0.321), but the odds for white matter hyperintensity presence were higher in INH than normotension (odds ratio, 1.504 [95% CI, 1.097– 2.062]; P=0.011). CONCLUSIONS: INH was common in the general population and associated with increased arterial stiffness, left ventricular hypertrophy, and diastolic dysfunction. White matter hyperintensity was more likely to be present in the INH group than in the normotension group. The use of ambulatory blood pressure monitoring should be encouraged to identify masked INH and prevent the occurrence of cardiovascular events.

Original languageEnglish
Article numbere025641
JournalJournal of the American Heart Association
Volume11
Issue number19
DOIs
StatePublished - 1 Oct 2022

Keywords

  • ambulatory blood pressure
  • nocturnal hypertension
  • target organ damage
  • white matter hyperintensity

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