Prevalence and risk factors of elevated alanine aminotransferase among Korean adolescents

2001-2014

Research output: Contribution to journalReview articleResearchpeer-review

2 Citations (Scopus)

Abstract

Background: An elevated alanine aminotransferase (ALT) level is a surrogate marker of non-alcoholic fatty liver disease (NAFLD), the most common liver disorder in adolescents. The majority of previous NAFLD studies in adolescents were performed in selected obese populations or had a cross-sectional design without a time-trend analysis. The purpose of this study was to estimate the prevalence and time trends of elevated ALT levels in a general adolescent population and to identify factors associated with ALT elevation. Methods: We analysed data of adolescent participants (aged 10-18 years) from the Korean National Health and Nutrition Examination Survey 2001-2014, a representative sample of the general population in South Korea. Suspected NAFLD was defined as ALT elevation (> 30 U/L) without hepatitis B surface antigen. In all statistical analyses, sampling weight- and design-based data were used. Results: ALT was elevated in 5.3% (standard error: 0.3%) of the study population of adolescent participants (N = 8455). No significant trends were found from 2001 to 2014 in the prevalence of elevated ALT among male and female adolescents. In multiple logistic regression analysis, elevated ALT was independently associated with sex (odds ratio [OR] male versus female 4.5; 95% CI, 3.3-6.2), obesity (OR 7.6; 95% CI, 5.3-11.0), and truncal obesity (OR 2.5; 95% CI, 1.8-3.5). Furthermore, male sex, obesity, truncal obesity and high household income level were associated with log-transformed ALT levels in multiple regression analysis. Conclusions: In Korean adolescents of both genders, the prevalence of elevated ALT levels was stable from 2001 to 2014. This study has revealed that sex, obesity, truncal obesity and household income level are associated with ALT elevation in adolescents.

Original languageEnglish
Article number617
JournalBMC Public Health
Volume18
Issue number1
DOIs
StatePublished - 11 May 2018

Fingerprint

Alanine Transaminase
Obesity
Odds Ratio
Population
Regression Analysis
Republic of Korea
Nutrition Surveys
Sex Ratio
Hepatitis B Surface Antigens
Biomarkers
Logistic Models
Weights and Measures
Liver

Keywords

  • Alanine aminotransferase
  • Fatty liver
  • Prevalence

Cite this

@article{9e95cbd16f0a4c159db9463112aa4fcc,
title = "Prevalence and risk factors of elevated alanine aminotransferase among Korean adolescents: 2001-2014",
abstract = "Background: An elevated alanine aminotransferase (ALT) level is a surrogate marker of non-alcoholic fatty liver disease (NAFLD), the most common liver disorder in adolescents. The majority of previous NAFLD studies in adolescents were performed in selected obese populations or had a cross-sectional design without a time-trend analysis. The purpose of this study was to estimate the prevalence and time trends of elevated ALT levels in a general adolescent population and to identify factors associated with ALT elevation. Methods: We analysed data of adolescent participants (aged 10-18 years) from the Korean National Health and Nutrition Examination Survey 2001-2014, a representative sample of the general population in South Korea. Suspected NAFLD was defined as ALT elevation (> 30 U/L) without hepatitis B surface antigen. In all statistical analyses, sampling weight- and design-based data were used. Results: ALT was elevated in 5.3{\%} (standard error: 0.3{\%}) of the study population of adolescent participants (N = 8455). No significant trends were found from 2001 to 2014 in the prevalence of elevated ALT among male and female adolescents. In multiple logistic regression analysis, elevated ALT was independently associated with sex (odds ratio [OR] male versus female 4.5; 95{\%} CI, 3.3-6.2), obesity (OR 7.6; 95{\%} CI, 5.3-11.0), and truncal obesity (OR 2.5; 95{\%} CI, 1.8-3.5). Furthermore, male sex, obesity, truncal obesity and high household income level were associated with log-transformed ALT levels in multiple regression analysis. Conclusions: In Korean adolescents of both genders, the prevalence of elevated ALT levels was stable from 2001 to 2014. This study has revealed that sex, obesity, truncal obesity and household income level are associated with ALT elevation in adolescents.",
keywords = "Alanine aminotransferase, Fatty liver, Prevalence",
author = "Kim, {Joo Whee} and Lee, {Kyung Jae} and Hyeran Yang and Chang, {Ju Young} and Moon, {Jin Soo} and Young-Ho Khang and Jaesung Ko",
year = "2018",
month = "5",
day = "11",
doi = "10.1186/s12889-018-5548-9",
language = "English",
volume = "18",
journal = "BMC Public Health",
issn = "1471-2458",
publisher = "BioMed Central Ltd.",
number = "1",

}

Prevalence and risk factors of elevated alanine aminotransferase among Korean adolescents : 2001-2014. / Kim, Joo Whee; Lee, Kyung Jae; Yang, Hyeran; Chang, Ju Young; Moon, Jin Soo; Khang, Young-Ho; Ko, Jaesung.

In: BMC Public Health, Vol. 18, No. 1, 617, 11.05.2018.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Prevalence and risk factors of elevated alanine aminotransferase among Korean adolescents

T2 - 2001-2014

AU - Kim, Joo Whee

AU - Lee, Kyung Jae

AU - Yang, Hyeran

AU - Chang, Ju Young

AU - Moon, Jin Soo

AU - Khang, Young-Ho

AU - Ko, Jaesung

PY - 2018/5/11

Y1 - 2018/5/11

N2 - Background: An elevated alanine aminotransferase (ALT) level is a surrogate marker of non-alcoholic fatty liver disease (NAFLD), the most common liver disorder in adolescents. The majority of previous NAFLD studies in adolescents were performed in selected obese populations or had a cross-sectional design without a time-trend analysis. The purpose of this study was to estimate the prevalence and time trends of elevated ALT levels in a general adolescent population and to identify factors associated with ALT elevation. Methods: We analysed data of adolescent participants (aged 10-18 years) from the Korean National Health and Nutrition Examination Survey 2001-2014, a representative sample of the general population in South Korea. Suspected NAFLD was defined as ALT elevation (> 30 U/L) without hepatitis B surface antigen. In all statistical analyses, sampling weight- and design-based data were used. Results: ALT was elevated in 5.3% (standard error: 0.3%) of the study population of adolescent participants (N = 8455). No significant trends were found from 2001 to 2014 in the prevalence of elevated ALT among male and female adolescents. In multiple logistic regression analysis, elevated ALT was independently associated with sex (odds ratio [OR] male versus female 4.5; 95% CI, 3.3-6.2), obesity (OR 7.6; 95% CI, 5.3-11.0), and truncal obesity (OR 2.5; 95% CI, 1.8-3.5). Furthermore, male sex, obesity, truncal obesity and high household income level were associated with log-transformed ALT levels in multiple regression analysis. Conclusions: In Korean adolescents of both genders, the prevalence of elevated ALT levels was stable from 2001 to 2014. This study has revealed that sex, obesity, truncal obesity and household income level are associated with ALT elevation in adolescents.

AB - Background: An elevated alanine aminotransferase (ALT) level is a surrogate marker of non-alcoholic fatty liver disease (NAFLD), the most common liver disorder in adolescents. The majority of previous NAFLD studies in adolescents were performed in selected obese populations or had a cross-sectional design without a time-trend analysis. The purpose of this study was to estimate the prevalence and time trends of elevated ALT levels in a general adolescent population and to identify factors associated with ALT elevation. Methods: We analysed data of adolescent participants (aged 10-18 years) from the Korean National Health and Nutrition Examination Survey 2001-2014, a representative sample of the general population in South Korea. Suspected NAFLD was defined as ALT elevation (> 30 U/L) without hepatitis B surface antigen. In all statistical analyses, sampling weight- and design-based data were used. Results: ALT was elevated in 5.3% (standard error: 0.3%) of the study population of adolescent participants (N = 8455). No significant trends were found from 2001 to 2014 in the prevalence of elevated ALT among male and female adolescents. In multiple logistic regression analysis, elevated ALT was independently associated with sex (odds ratio [OR] male versus female 4.5; 95% CI, 3.3-6.2), obesity (OR 7.6; 95% CI, 5.3-11.0), and truncal obesity (OR 2.5; 95% CI, 1.8-3.5). Furthermore, male sex, obesity, truncal obesity and high household income level were associated with log-transformed ALT levels in multiple regression analysis. Conclusions: In Korean adolescents of both genders, the prevalence of elevated ALT levels was stable from 2001 to 2014. This study has revealed that sex, obesity, truncal obesity and household income level are associated with ALT elevation in adolescents.

KW - Alanine aminotransferase

KW - Fatty liver

KW - Prevalence

UR - http://www.scopus.com/inward/record.url?scp=85046956208&partnerID=8YFLogxK

U2 - 10.1186/s12889-018-5548-9

DO - 10.1186/s12889-018-5548-9

M3 - Review article

VL - 18

JO - BMC Public Health

JF - BMC Public Health

SN - 1471-2458

IS - 1

M1 - 617

ER -