Presence of Embolic Source and Outcome in Central Retinal Artery Occlusion

Dong Wan Kang, Keun Hwa Jung, Wookjin Yang, Hyeong Min Kim, Youngjoon Kim, Matthew Chung, Jiyeon Ha, Monique Therese Punsalan, Eung Joon Lee, Han Yeong Jeong, Jeong Min Kim, Sang Bae Ko, Seung Hoon Lee

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

ObjectivesThe etiology of central retinal artery occlusion (CRAO) is unclear in approximately 50% of patients, suggesting pathomechanical heterogeneity; moreover, little is known about outcomes according to etiology. This study investigated whether the presence of an embolic source affects outcome in CRAO.MethodsCRAO patients within 7 days of symptom onset were retrospectively enrolled. Clinical parameters, including initial and 1-month visual acuity, CRAO subtype, and brain images, were reviewed. CRAO etiology was categorized as CRAO with or without an embolic source (CRAO-E+ and CRAO-E-). Visual improvement was defined as a decrease in logarithm of the minimum angle of resolution ≥0.3 at 1 month.ResultsA total of 114 patients with CRAO were included. Visual improvement was noted in 40.4% of patients. Embolic sources were identified in 55.3% of patients, and visual improvement group rather than no improvement group was more commonly associated with the presence of an embolic source. In multivariable logistic regression analysis, CRAO-E+ independently predicted visual improvement (odds ratio 3.00, 95% CI 1.15-7.81, p = 0.025).DiscussionCRAO-E+ was found to be associated with a better outcome. CRAO-E+ may be more prone to recanalization than that CRAO-E-.

Original languageEnglish
Pages (from-to)E1364-E1369
JournalNeurology
Volume101
Issue number13
DOIs
StatePublished - 26 Sep 2023

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Publisher Copyright:
© 2023 American Academy of Neurology.

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