Prenatal exposure to mixtures of heavy metals and neurodevelopment in infants at 6 months

Surabhi Shah-Kulkarni, Seulbi Lee, Kyoung Sook Jeong, Yun Chul Hong, Hyesook Park, Mina Ha, Yangho Kim, Eun Hee Ha

Research output: Contribution to journalArticle

Abstract

Background: Exposure to mixture of neurotoxic metals such as lead, mercury and cadmium occurs at a specific point of time. When exposed to metal mixtures, one metal may act as an agonist or antagonist to another metal. Thus, it is important to study the effects of exposure to a combination of metals on children's development using advance statistical methods. Objectives: In this study, we explored the effects of prenatal metal exposure including lead, mercury and cadmium in early pregnancy (12–20 weeks), late pregnancy (>28 weeks), and at birth on neurodevelopment of infants at 6 months of age. Methods: We included 523 eligible mother-child pairs from the mothers and children environmental health (MOCEH) study, a prospective birth cohort study in Korea. We used linear regression, Bayesian kernel machine regression (BKMR) and generalized additive models (GAM), to evaluate the effects of exposure to metal mixtures on neurodevelopment of infants aged 6 months. The Korean version of Bayley scale of infant and toddler development-II was used to measure the child's neurodevelopment. Results: Linear regression models showed a significant negative effect of lead exposure during late pregnancy on the mental development index (MDI) [β = -2.51 (−4.92, −0.10)] scores of infants aged 6 months following co-exposure to mercury. Further, linear regression analysis showed a significant interaction between late pregnancy lead and mercury concentrations. BKMR analysis showed similar results as those obtained in linear regression models. These results were also replicated in the GAM. Stratification analysis showed that greater than 50 percentile concentration of mercury in late pregnancy potentiated the adverse effects of lead in late pregnancy on MDI [β = −4.33 (−7.66, −1.00)] and psychomotor development index (PDI) [β = −5.30 (−9.13, −1.46)] at 6 months of age. Prenatal cadmium exposure did not show a significant association with MDI and PDI at 6 months in the linear regression or BKMR analysis. Conclusion: Based on all the statistical methods used, we demonstrated the effect of combined exposure to metals on the neurodevelopment of infants aged 6 months, with significant interaction between lead and mercury.

Original languageEnglish
Article number109122
JournalEnvironmental Research
Volume182
DOIs
StatePublished - Mar 2020

Fingerprint

Heavy Metals
Metals
Mercury
Linear Models
pregnancy
heavy metal
Linear regression
metal
Pregnancy
Cadmium
Regression analysis
regression analysis
cadmium
Regression Analysis
Child Development
Statistical methods
Mothers
Parturition
child development
Environmental Health

Keywords

  • Birth cohort study
  • Metal mixtures
  • Multiple pollutants
  • Neurodevelopment

Cite this

Shah-Kulkarni, Surabhi ; Lee, Seulbi ; Jeong, Kyoung Sook ; Hong, Yun Chul ; Park, Hyesook ; Ha, Mina ; Kim, Yangho ; Ha, Eun Hee. / Prenatal exposure to mixtures of heavy metals and neurodevelopment in infants at 6 months. In: Environmental Research. 2020 ; Vol. 182.
@article{5c9f1d4498e24e23896607d25107db6d,
title = "Prenatal exposure to mixtures of heavy metals and neurodevelopment in infants at 6 months",
abstract = "Background: Exposure to mixture of neurotoxic metals such as lead, mercury and cadmium occurs at a specific point of time. When exposed to metal mixtures, one metal may act as an agonist or antagonist to another metal. Thus, it is important to study the effects of exposure to a combination of metals on children's development using advance statistical methods. Objectives: In this study, we explored the effects of prenatal metal exposure including lead, mercury and cadmium in early pregnancy (12–20 weeks), late pregnancy (>28 weeks), and at birth on neurodevelopment of infants at 6 months of age. Methods: We included 523 eligible mother-child pairs from the mothers and children environmental health (MOCEH) study, a prospective birth cohort study in Korea. We used linear regression, Bayesian kernel machine regression (BKMR) and generalized additive models (GAM), to evaluate the effects of exposure to metal mixtures on neurodevelopment of infants aged 6 months. The Korean version of Bayley scale of infant and toddler development-II was used to measure the child's neurodevelopment. Results: Linear regression models showed a significant negative effect of lead exposure during late pregnancy on the mental development index (MDI) [β = -2.51 (−4.92, −0.10)] scores of infants aged 6 months following co-exposure to mercury. Further, linear regression analysis showed a significant interaction between late pregnancy lead and mercury concentrations. BKMR analysis showed similar results as those obtained in linear regression models. These results were also replicated in the GAM. Stratification analysis showed that greater than 50 percentile concentration of mercury in late pregnancy potentiated the adverse effects of lead in late pregnancy on MDI [β = −4.33 (−7.66, −1.00)] and psychomotor development index (PDI) [β = −5.30 (−9.13, −1.46)] at 6 months of age. Prenatal cadmium exposure did not show a significant association with MDI and PDI at 6 months in the linear regression or BKMR analysis. Conclusion: Based on all the statistical methods used, we demonstrated the effect of combined exposure to metals on the neurodevelopment of infants aged 6 months, with significant interaction between lead and mercury.",
keywords = "Birth cohort study, Metal mixtures, Multiple pollutants, Neurodevelopment",
author = "Surabhi Shah-Kulkarni and Seulbi Lee and Jeong, {Kyoung Sook} and Hong, {Yun Chul} and Hyesook Park and Mina Ha and Yangho Kim and Ha, {Eun Hee}",
year = "2020",
month = "3",
doi = "10.1016/j.envres.2020.109122",
language = "English",
volume = "182",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press Inc.",

}

Prenatal exposure to mixtures of heavy metals and neurodevelopment in infants at 6 months. / Shah-Kulkarni, Surabhi; Lee, Seulbi; Jeong, Kyoung Sook; Hong, Yun Chul; Park, Hyesook; Ha, Mina; Kim, Yangho; Ha, Eun Hee.

In: Environmental Research, Vol. 182, 109122, 03.2020.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prenatal exposure to mixtures of heavy metals and neurodevelopment in infants at 6 months

AU - Shah-Kulkarni, Surabhi

AU - Lee, Seulbi

AU - Jeong, Kyoung Sook

AU - Hong, Yun Chul

AU - Park, Hyesook

AU - Ha, Mina

AU - Kim, Yangho

AU - Ha, Eun Hee

PY - 2020/3

Y1 - 2020/3

N2 - Background: Exposure to mixture of neurotoxic metals such as lead, mercury and cadmium occurs at a specific point of time. When exposed to metal mixtures, one metal may act as an agonist or antagonist to another metal. Thus, it is important to study the effects of exposure to a combination of metals on children's development using advance statistical methods. Objectives: In this study, we explored the effects of prenatal metal exposure including lead, mercury and cadmium in early pregnancy (12–20 weeks), late pregnancy (>28 weeks), and at birth on neurodevelopment of infants at 6 months of age. Methods: We included 523 eligible mother-child pairs from the mothers and children environmental health (MOCEH) study, a prospective birth cohort study in Korea. We used linear regression, Bayesian kernel machine regression (BKMR) and generalized additive models (GAM), to evaluate the effects of exposure to metal mixtures on neurodevelopment of infants aged 6 months. The Korean version of Bayley scale of infant and toddler development-II was used to measure the child's neurodevelopment. Results: Linear regression models showed a significant negative effect of lead exposure during late pregnancy on the mental development index (MDI) [β = -2.51 (−4.92, −0.10)] scores of infants aged 6 months following co-exposure to mercury. Further, linear regression analysis showed a significant interaction between late pregnancy lead and mercury concentrations. BKMR analysis showed similar results as those obtained in linear regression models. These results were also replicated in the GAM. Stratification analysis showed that greater than 50 percentile concentration of mercury in late pregnancy potentiated the adverse effects of lead in late pregnancy on MDI [β = −4.33 (−7.66, −1.00)] and psychomotor development index (PDI) [β = −5.30 (−9.13, −1.46)] at 6 months of age. Prenatal cadmium exposure did not show a significant association with MDI and PDI at 6 months in the linear regression or BKMR analysis. Conclusion: Based on all the statistical methods used, we demonstrated the effect of combined exposure to metals on the neurodevelopment of infants aged 6 months, with significant interaction between lead and mercury.

AB - Background: Exposure to mixture of neurotoxic metals such as lead, mercury and cadmium occurs at a specific point of time. When exposed to metal mixtures, one metal may act as an agonist or antagonist to another metal. Thus, it is important to study the effects of exposure to a combination of metals on children's development using advance statistical methods. Objectives: In this study, we explored the effects of prenatal metal exposure including lead, mercury and cadmium in early pregnancy (12–20 weeks), late pregnancy (>28 weeks), and at birth on neurodevelopment of infants at 6 months of age. Methods: We included 523 eligible mother-child pairs from the mothers and children environmental health (MOCEH) study, a prospective birth cohort study in Korea. We used linear regression, Bayesian kernel machine regression (BKMR) and generalized additive models (GAM), to evaluate the effects of exposure to metal mixtures on neurodevelopment of infants aged 6 months. The Korean version of Bayley scale of infant and toddler development-II was used to measure the child's neurodevelopment. Results: Linear regression models showed a significant negative effect of lead exposure during late pregnancy on the mental development index (MDI) [β = -2.51 (−4.92, −0.10)] scores of infants aged 6 months following co-exposure to mercury. Further, linear regression analysis showed a significant interaction between late pregnancy lead and mercury concentrations. BKMR analysis showed similar results as those obtained in linear regression models. These results were also replicated in the GAM. Stratification analysis showed that greater than 50 percentile concentration of mercury in late pregnancy potentiated the adverse effects of lead in late pregnancy on MDI [β = −4.33 (−7.66, −1.00)] and psychomotor development index (PDI) [β = −5.30 (−9.13, −1.46)] at 6 months of age. Prenatal cadmium exposure did not show a significant association with MDI and PDI at 6 months in the linear regression or BKMR analysis. Conclusion: Based on all the statistical methods used, we demonstrated the effect of combined exposure to metals on the neurodevelopment of infants aged 6 months, with significant interaction between lead and mercury.

KW - Birth cohort study

KW - Metal mixtures

KW - Multiple pollutants

KW - Neurodevelopment

UR - http://www.scopus.com/inward/record.url?scp=85077931100&partnerID=8YFLogxK

U2 - 10.1016/j.envres.2020.109122

DO - 10.1016/j.envres.2020.109122

M3 - Article

AN - SCOPUS:85077931100

VL - 182

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

M1 - 109122

ER -