Predictors of recurrence after thymoma resection

Mi Kyung Bae, Chang Young Lee, Jin Gu Lee, In Kyu Park, Dae Joon Kim, Woo Ick Yang, Kyung Young Chung

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: Recurrence rate is considered a better measure of clinical outcomes after thymoma resection than overall survival due to the indolent behavior of thymomas. This study was designed to determine predictors of recurrence after thymoma resection. Materials and Methods: A single-institution, retrospective study was performed, including 305 patients who had undergone thymoma resection between 1986 and 2009. Results: Among 305 patients, recurrence was observed in 41 patients (13.4%). The recurrence rates were 0% (0/19), 6.3% (4/63), 4.2% (2/48), 18.6% (11/59) and 20.7% (24/116) for type A, AB, B1, B2 and B3 tumors, respectively. The recurrence rate according to Masaoka stage was 6.1% (8/132), 11.4% (13/114), 26.8% (11/41) and 50.0% (9/18) for stages I, II, III and IV, respectively. After univariate analysis, completeness of resection (R0 versus R1), World Health Organization (WHO) histologic type (A, AB, B1 versus B2, B3), Masaoka stage, and size of tumor (<8 cm versus ≥8 cm) demonstrated significant differences with freedom from recurrence. Upon multivariate analysis, Masaoka stage was the only independent predictor of recurrence. Conclusion: WHO histologic type, Masaoka stage, and size of tumor were associated with recurrence. Particularly, Masaoka stage was the only independent predictor of recurrence after thymoma resection.

Original languageEnglish
Pages (from-to)875-882
Number of pages8
JournalYonsei Medical Journal
Volume54
Issue number4
DOIs
StatePublished - 1 Jul 2013

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Thymoma
Recurrence
Neoplasms
Multivariate Analysis
Retrospective Studies
Outcome Assessment (Health Care)
Survival

Keywords

  • Outcomes
  • Surgery
  • Thymoma

Cite this

Bae, M. K., Lee, C. Y., Lee, J. G., Park, I. K., Kim, D. J., Yang, W. I., & Chung, K. Y. (2013). Predictors of recurrence after thymoma resection. Yonsei Medical Journal, 54(4), 875-882. https://doi.org/10.3349/ymj.2013.54.4.875
Bae, Mi Kyung ; Lee, Chang Young ; Lee, Jin Gu ; Park, In Kyu ; Kim, Dae Joon ; Yang, Woo Ick ; Chung, Kyung Young. / Predictors of recurrence after thymoma resection. In: Yonsei Medical Journal. 2013 ; Vol. 54, No. 4. pp. 875-882.
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Bae, MK, Lee, CY, Lee, JG, Park, IK, Kim, DJ, Yang, WI & Chung, KY 2013, 'Predictors of recurrence after thymoma resection', Yonsei Medical Journal, vol. 54, no. 4, pp. 875-882. https://doi.org/10.3349/ymj.2013.54.4.875

Predictors of recurrence after thymoma resection. / Bae, Mi Kyung; Lee, Chang Young; Lee, Jin Gu; Park, In Kyu; Kim, Dae Joon; Yang, Woo Ick; Chung, Kyung Young.

In: Yonsei Medical Journal, Vol. 54, No. 4, 01.07.2013, p. 875-882.

Research output: Contribution to journalArticle

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T1 - Predictors of recurrence after thymoma resection

AU - Bae, Mi Kyung

AU - Lee, Chang Young

AU - Lee, Jin Gu

AU - Park, In Kyu

AU - Kim, Dae Joon

AU - Yang, Woo Ick

AU - Chung, Kyung Young

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N2 - Purpose: Recurrence rate is considered a better measure of clinical outcomes after thymoma resection than overall survival due to the indolent behavior of thymomas. This study was designed to determine predictors of recurrence after thymoma resection. Materials and Methods: A single-institution, retrospective study was performed, including 305 patients who had undergone thymoma resection between 1986 and 2009. Results: Among 305 patients, recurrence was observed in 41 patients (13.4%). The recurrence rates were 0% (0/19), 6.3% (4/63), 4.2% (2/48), 18.6% (11/59) and 20.7% (24/116) for type A, AB, B1, B2 and B3 tumors, respectively. The recurrence rate according to Masaoka stage was 6.1% (8/132), 11.4% (13/114), 26.8% (11/41) and 50.0% (9/18) for stages I, II, III and IV, respectively. After univariate analysis, completeness of resection (R0 versus R1), World Health Organization (WHO) histologic type (A, AB, B1 versus B2, B3), Masaoka stage, and size of tumor (<8 cm versus ≥8 cm) demonstrated significant differences with freedom from recurrence. Upon multivariate analysis, Masaoka stage was the only independent predictor of recurrence. Conclusion: WHO histologic type, Masaoka stage, and size of tumor were associated with recurrence. Particularly, Masaoka stage was the only independent predictor of recurrence after thymoma resection.

AB - Purpose: Recurrence rate is considered a better measure of clinical outcomes after thymoma resection than overall survival due to the indolent behavior of thymomas. This study was designed to determine predictors of recurrence after thymoma resection. Materials and Methods: A single-institution, retrospective study was performed, including 305 patients who had undergone thymoma resection between 1986 and 2009. Results: Among 305 patients, recurrence was observed in 41 patients (13.4%). The recurrence rates were 0% (0/19), 6.3% (4/63), 4.2% (2/48), 18.6% (11/59) and 20.7% (24/116) for type A, AB, B1, B2 and B3 tumors, respectively. The recurrence rate according to Masaoka stage was 6.1% (8/132), 11.4% (13/114), 26.8% (11/41) and 50.0% (9/18) for stages I, II, III and IV, respectively. After univariate analysis, completeness of resection (R0 versus R1), World Health Organization (WHO) histologic type (A, AB, B1 versus B2, B3), Masaoka stage, and size of tumor (<8 cm versus ≥8 cm) demonstrated significant differences with freedom from recurrence. Upon multivariate analysis, Masaoka stage was the only independent predictor of recurrence. Conclusion: WHO histologic type, Masaoka stage, and size of tumor were associated with recurrence. Particularly, Masaoka stage was the only independent predictor of recurrence after thymoma resection.

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