Predictors of pre-operative cognitive impairment in meningioma patients over 60 years old

Min Ju Kang, Jung Min Pyun, Min Jae Baek, Kihwan Hwang, Jung Ho Han, Young Ho Park, Chae Yong Kim, Sang Yun Kim

Research output: Contribution to journalArticle


Background: The aim of this study was to assess the cognitive function of patients over 60 years old with meningioma using a domain-specific neuropsychological test and to investigate the relevant factors affecting pre-operative cognitive decline in different subdomains. Methods: We retrospectively investigated 46 intracranial meningioma patients between the ages of 60 and 85 years. All patients underwent brain MRI and neuropsychological test. Tumor size, location, peritumoral edema, and medial temporal atrophy (MTA) were examined to determine the association with cognitive impairment. We performed a logistic regression analysis to examine the odds ratios (ORs) for cognitive decline of four subdomains: Verbal memory, language, visuospatial, and executive functions. Results: Tumor size and age were associated with executive dysfunction (OR 1.083, 95% confidence interval (CI) 1.006-1.166, and OR 1.209, 95% CI 1.018-1.436, respectively). There was no statistically significant association in other cognitive domains (language, verbal memory, and visuospatial function) with variables in regression analysis. Conclusions: We conclude that tumor size and age are positively related with executive function in pre-operative meningioma patients over 60 years old.

Original languageEnglish
Article number225
JournalBMC Neurology
Issue number1
StatePublished - 3 Jun 2020


  • Cognitive dysfunction
  • Meningioma
  • Neuropsychological tests

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