Prediction of the therapeutic response after FOLFOX and FOLFIRI treatment for patients with liver metastasis from colorectal cancer using computerized CT texture analysis

Su Joa Ahn, Jung Hoon Kim, Sang Joon Park, Joon Koo Han

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Purpose To determine whether baseline CT texture analysis of hepatic metastasis from colorectal cancer (CRC) is predictive of therapeutic response after cytotoxic chemotherapy. Materials and methods 235 patients with liver metastasis from CRC who underwent CT and cytotoxic chemotherapy using FOLFOX and FOLFIRI were divided into derivation cohort (n = 145) and validation cohort (n = 90). The CT texture of the hepatic metastasis was quantified using baseline CT. We analyzed the independent predictor for the response from derivation cohort and validated it using validation cohort. We also compared texture features between included four CT scanners. Results 89 responding and 146 non-responding patients were evaluated. In the derivation cohort, lower skewness (OR, 6.739) in 2D, higher mean attenuation (OR, 2.587), and narrower standard deviation (SD) (OR, 3.163) in 3D were independently associated with response to chemotherapy. However, only lower skewness (P=0.213) on 2D and narrower SD on 3D analysis (P=0.097) did not show a significant difference on either CT scanner. When applied to the validation set, the lower skewness on 2D (AUC = 0.797) and narrower SD on 3D (AUC = 0.785) showed good performance. Conclusion CT texture analysis is useful for prediction of therapeutic response after cytotoxic chemotherapy in patients with liver metastasis from colorectal cancer.

Original languageEnglish
Pages (from-to)1867-1874
Number of pages8
JournalEuropean Journal of Radiology
Volume85
Issue number10
DOIs
StatePublished - 1 Oct 2016

Keywords

  • CT
  • Cytotoxic chemotherapy
  • Hepatic metastasis from colorectal cancer
  • Texture analysis
  • Therapeutic response

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