Postoperative delirium after hip surgery is a potential risk factor for incident dementia: A systematic review and meta-analysis of prospective studies

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Abstract

Background: Although a few trials have explored the relationship between postoperative delirium (POD) and incident dementia in patients with hip surgery, the numbers of participants in each study are relatively small. Thus, we performed a meta-analysis to examine whether POD after hip surgery is a risk factor for incident dementia. Methods: Six prospective cohort studies investigating the development of incident dementia in patients with POD after hip surgery were retrieved from PubMed, Embase, and the Cochrane Library. We performed a pairwise meta-analysis using fixed- and random- effect models. Results: POD significantly increased the risk of incident dementia and cognitive decline (overall odds ratio [ORs] = 8.957; 95 % confidence interval [CI], 5.444–14.737; P < 0.001 in fixed-effects model; overall ORs = 8.962; 95 % CI, 5.344–15.029; P < 0.001 in random-effects model). A publication bias was not evident in this study. Conclusions: Our meta-analysis revealed that POD after hip surgery is a risk factor for incident dementia. Early identification of cognitive function should be needed after surgery and appropriate prevention and treatment for dementia will be required, especially in cases with POD.

Original languageEnglish
Article number103977
JournalArchives of Gerontology and Geriatrics
Volume87
DOIs
StatePublished - 1 Mar 2020

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Delirium
dementia
surgery
Dementia
Meta-Analysis
Hip
incident
Prospective Studies
confidence
Odds Ratio
Confidence Intervals
Publication Bias
PubMed
Cognition
Libraries
Cohort Studies
trend

Keywords

  • Delirium
  • Dementia
  • Hip fractures
  • Hip replacement
  • Meta-analysis

Cite this

@article{f0667bdcf1924f3f8931dc2d733cb033,
title = "Postoperative delirium after hip surgery is a potential risk factor for incident dementia: A systematic review and meta-analysis of prospective studies",
abstract = "Background: Although a few trials have explored the relationship between postoperative delirium (POD) and incident dementia in patients with hip surgery, the numbers of participants in each study are relatively small. Thus, we performed a meta-analysis to examine whether POD after hip surgery is a risk factor for incident dementia. Methods: Six prospective cohort studies investigating the development of incident dementia in patients with POD after hip surgery were retrieved from PubMed, Embase, and the Cochrane Library. We performed a pairwise meta-analysis using fixed- and random- effect models. Results: POD significantly increased the risk of incident dementia and cognitive decline (overall odds ratio [ORs] = 8.957; 95 {\%} confidence interval [CI], 5.444–14.737; P < 0.001 in fixed-effects model; overall ORs = 8.962; 95 {\%} CI, 5.344–15.029; P < 0.001 in random-effects model). A publication bias was not evident in this study. Conclusions: Our meta-analysis revealed that POD after hip surgery is a risk factor for incident dementia. Early identification of cognitive function should be needed after surgery and appropriate prevention and treatment for dementia will be required, especially in cases with POD.",
keywords = "Delirium, Dementia, Hip fractures, Hip replacement, Meta-analysis",
author = "Lee, {Soong Joon} and Jung, {Se Hee} and Lee, {Shi Uk} and Lim, {Jae Young} and Yoon, {Kang Sup} and Lee, {Sang Yoon}",
year = "2020",
month = "3",
day = "1",
doi = "10.1016/j.archger.2019.103977",
language = "English",
volume = "87",
journal = "Archives of Gerontology and Geriatrics",
issn = "0167-4943",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Postoperative delirium after hip surgery is a potential risk factor for incident dementia

T2 - A systematic review and meta-analysis of prospective studies

AU - Lee, Soong Joon

AU - Jung, Se Hee

AU - Lee, Shi Uk

AU - Lim, Jae Young

AU - Yoon, Kang Sup

AU - Lee, Sang Yoon

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Background: Although a few trials have explored the relationship between postoperative delirium (POD) and incident dementia in patients with hip surgery, the numbers of participants in each study are relatively small. Thus, we performed a meta-analysis to examine whether POD after hip surgery is a risk factor for incident dementia. Methods: Six prospective cohort studies investigating the development of incident dementia in patients with POD after hip surgery were retrieved from PubMed, Embase, and the Cochrane Library. We performed a pairwise meta-analysis using fixed- and random- effect models. Results: POD significantly increased the risk of incident dementia and cognitive decline (overall odds ratio [ORs] = 8.957; 95 % confidence interval [CI], 5.444–14.737; P < 0.001 in fixed-effects model; overall ORs = 8.962; 95 % CI, 5.344–15.029; P < 0.001 in random-effects model). A publication bias was not evident in this study. Conclusions: Our meta-analysis revealed that POD after hip surgery is a risk factor for incident dementia. Early identification of cognitive function should be needed after surgery and appropriate prevention and treatment for dementia will be required, especially in cases with POD.

AB - Background: Although a few trials have explored the relationship between postoperative delirium (POD) and incident dementia in patients with hip surgery, the numbers of participants in each study are relatively small. Thus, we performed a meta-analysis to examine whether POD after hip surgery is a risk factor for incident dementia. Methods: Six prospective cohort studies investigating the development of incident dementia in patients with POD after hip surgery were retrieved from PubMed, Embase, and the Cochrane Library. We performed a pairwise meta-analysis using fixed- and random- effect models. Results: POD significantly increased the risk of incident dementia and cognitive decline (overall odds ratio [ORs] = 8.957; 95 % confidence interval [CI], 5.444–14.737; P < 0.001 in fixed-effects model; overall ORs = 8.962; 95 % CI, 5.344–15.029; P < 0.001 in random-effects model). A publication bias was not evident in this study. Conclusions: Our meta-analysis revealed that POD after hip surgery is a risk factor for incident dementia. Early identification of cognitive function should be needed after surgery and appropriate prevention and treatment for dementia will be required, especially in cases with POD.

KW - Delirium

KW - Dementia

KW - Hip fractures

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KW - Meta-analysis

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