Possible benefits from post-mastectomy radiotherapy in nodenegative breast cancer patients: A multicenter analysis in Korea (KROG 14-22)

Hae Jin Park, Kyung Hwan Shin, Jin Ho Kim, Seung Do Ahn, Su Ssan Kim, Yong Bae Kim, Won Park, Yeon Joo Kim, Hyun Soo Shin, Jin Hee Kim, Sun Young Lee, Kyubo Kim, Kyung Ran Park, Bae Kwon Jeong

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Abstract

Purpose: This study was performed to identify a subset of patients who may benefit from post-mastectomy radiotherapy (PMRT) among node-negative breast cancer patients. Materials and Methods: We retrospectively reviewed 1,828 patients with pT1- 2N0 breast cancer, treated with mastectomy without PMRT from 2005 to 2010 at 10 institutions. Univariate and multivariate analyses for locoregional recurrence (LRR) and any first recurrence (AFR) were performed according to clinicopathologic factors and biologic subtypes. Results: During a median follow-up period of 5.9 years (range: 0.7-10.4 years), 98 patients developed AFR (39 isolated LRR, 13 LRR with synchronous distant metastasis, and 46 isolated distant metastasis), and 52 patients developed LRR. The 7-year LRR and AFR rates were 3.8% and 6.7%, respectively. Multivariate analysis revealed that age of ≤ 40 years (p<0.001) and T2 stage (p=0.013) were independent risk factors for LRR. The 7-year LRR rates were 2.5% with no risk factors, 4.5% with one risk factor, and 12.4% with two risk factors. Multivariate analysis for AFR revealed that age of ≤ 40 years (p<0.001), T2 stage (p<0.001), and triple-negative biological subtype (p=0.045) were independent risk factors for AFR. The 7-year AFR rates were 3.9% with no risk factors, 8.4% with one risk factor, and 15.7% with two to three risk factors. Conclusions: Mastectomy without PMRT is a sufficient local treatment for pT1- 2N0M0 breast cancer. Nevertheless, PMRT might be considered for patients with two or three risk factors, among those of young age, with T2 tumors, and with the triplenegative biological subtype based on LRR and AFR.

Original languageEnglish
Pages (from-to)59800-59809
Number of pages10
JournalOncotarget
Volume8
Issue number35
DOIs
StatePublished - 1 Jan 2017

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Mastectomy
Korea
Radiotherapy
Breast Neoplasms
Recurrence
Multivariate Analysis
Neoplasm Metastasis
Biological Factors

Keywords

  • Breast cancer
  • Post-mastectomy radiotherapy
  • Risk factors

Cite this

Park, Hae Jin ; Shin, Kyung Hwan ; Kim, Jin Ho ; Ahn, Seung Do ; Kim, Su Ssan ; Kim, Yong Bae ; Park, Won ; Kim, Yeon Joo ; Shin, Hyun Soo ; Kim, Jin Hee ; Lee, Sun Young ; Kim, Kyubo ; Park, Kyung Ran ; Jeong, Bae Kwon. / Possible benefits from post-mastectomy radiotherapy in nodenegative breast cancer patients : A multicenter analysis in Korea (KROG 14-22). In: Oncotarget. 2017 ; Vol. 8, No. 35. pp. 59800-59809.
@article{312bce2dbf9749f6bb9cc895fbe1ff5d,
title = "Possible benefits from post-mastectomy radiotherapy in nodenegative breast cancer patients: A multicenter analysis in Korea (KROG 14-22)",
abstract = "Purpose: This study was performed to identify a subset of patients who may benefit from post-mastectomy radiotherapy (PMRT) among node-negative breast cancer patients. Materials and Methods: We retrospectively reviewed 1,828 patients with pT1- 2N0 breast cancer, treated with mastectomy without PMRT from 2005 to 2010 at 10 institutions. Univariate and multivariate analyses for locoregional recurrence (LRR) and any first recurrence (AFR) were performed according to clinicopathologic factors and biologic subtypes. Results: During a median follow-up period of 5.9 years (range: 0.7-10.4 years), 98 patients developed AFR (39 isolated LRR, 13 LRR with synchronous distant metastasis, and 46 isolated distant metastasis), and 52 patients developed LRR. The 7-year LRR and AFR rates were 3.8{\%} and 6.7{\%}, respectively. Multivariate analysis revealed that age of ≤ 40 years (p<0.001) and T2 stage (p=0.013) were independent risk factors for LRR. The 7-year LRR rates were 2.5{\%} with no risk factors, 4.5{\%} with one risk factor, and 12.4{\%} with two risk factors. Multivariate analysis for AFR revealed that age of ≤ 40 years (p<0.001), T2 stage (p<0.001), and triple-negative biological subtype (p=0.045) were independent risk factors for AFR. The 7-year AFR rates were 3.9{\%} with no risk factors, 8.4{\%} with one risk factor, and 15.7{\%} with two to three risk factors. Conclusions: Mastectomy without PMRT is a sufficient local treatment for pT1- 2N0M0 breast cancer. Nevertheless, PMRT might be considered for patients with two or three risk factors, among those of young age, with T2 tumors, and with the triplenegative biological subtype based on LRR and AFR.",
keywords = "Breast cancer, Post-mastectomy radiotherapy, Risk factors",
author = "Park, {Hae Jin} and Shin, {Kyung Hwan} and Kim, {Jin Ho} and Ahn, {Seung Do} and Kim, {Su Ssan} and Kim, {Yong Bae} and Won Park and Kim, {Yeon Joo} and Shin, {Hyun Soo} and Kim, {Jin Hee} and Lee, {Sun Young} and Kyubo Kim and Park, {Kyung Ran} and Jeong, {Bae Kwon}",
year = "2017",
month = "1",
day = "1",
doi = "10.18632/oncotarget.16241",
language = "English",
volume = "8",
pages = "59800--59809",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "35",

}

Park, HJ, Shin, KH, Kim, JH, Ahn, SD, Kim, SS, Kim, YB, Park, W, Kim, YJ, Shin, HS, Kim, JH, Lee, SY, Kim, K, Park, KR & Jeong, BK 2017, 'Possible benefits from post-mastectomy radiotherapy in nodenegative breast cancer patients: A multicenter analysis in Korea (KROG 14-22)', Oncotarget, vol. 8, no. 35, pp. 59800-59809. https://doi.org/10.18632/oncotarget.16241

Possible benefits from post-mastectomy radiotherapy in nodenegative breast cancer patients : A multicenter analysis in Korea (KROG 14-22). / Park, Hae Jin; Shin, Kyung Hwan; Kim, Jin Ho; Ahn, Seung Do; Kim, Su Ssan; Kim, Yong Bae; Park, Won; Kim, Yeon Joo; Shin, Hyun Soo; Kim, Jin Hee; Lee, Sun Young; Kim, Kyubo; Park, Kyung Ran; Jeong, Bae Kwon.

In: Oncotarget, Vol. 8, No. 35, 01.01.2017, p. 59800-59809.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Possible benefits from post-mastectomy radiotherapy in nodenegative breast cancer patients

T2 - A multicenter analysis in Korea (KROG 14-22)

AU - Park, Hae Jin

AU - Shin, Kyung Hwan

AU - Kim, Jin Ho

AU - Ahn, Seung Do

AU - Kim, Su Ssan

AU - Kim, Yong Bae

AU - Park, Won

AU - Kim, Yeon Joo

AU - Shin, Hyun Soo

AU - Kim, Jin Hee

AU - Lee, Sun Young

AU - Kim, Kyubo

AU - Park, Kyung Ran

AU - Jeong, Bae Kwon

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Purpose: This study was performed to identify a subset of patients who may benefit from post-mastectomy radiotherapy (PMRT) among node-negative breast cancer patients. Materials and Methods: We retrospectively reviewed 1,828 patients with pT1- 2N0 breast cancer, treated with mastectomy without PMRT from 2005 to 2010 at 10 institutions. Univariate and multivariate analyses for locoregional recurrence (LRR) and any first recurrence (AFR) were performed according to clinicopathologic factors and biologic subtypes. Results: During a median follow-up period of 5.9 years (range: 0.7-10.4 years), 98 patients developed AFR (39 isolated LRR, 13 LRR with synchronous distant metastasis, and 46 isolated distant metastasis), and 52 patients developed LRR. The 7-year LRR and AFR rates were 3.8% and 6.7%, respectively. Multivariate analysis revealed that age of ≤ 40 years (p<0.001) and T2 stage (p=0.013) were independent risk factors for LRR. The 7-year LRR rates were 2.5% with no risk factors, 4.5% with one risk factor, and 12.4% with two risk factors. Multivariate analysis for AFR revealed that age of ≤ 40 years (p<0.001), T2 stage (p<0.001), and triple-negative biological subtype (p=0.045) were independent risk factors for AFR. The 7-year AFR rates were 3.9% with no risk factors, 8.4% with one risk factor, and 15.7% with two to three risk factors. Conclusions: Mastectomy without PMRT is a sufficient local treatment for pT1- 2N0M0 breast cancer. Nevertheless, PMRT might be considered for patients with two or three risk factors, among those of young age, with T2 tumors, and with the triplenegative biological subtype based on LRR and AFR.

AB - Purpose: This study was performed to identify a subset of patients who may benefit from post-mastectomy radiotherapy (PMRT) among node-negative breast cancer patients. Materials and Methods: We retrospectively reviewed 1,828 patients with pT1- 2N0 breast cancer, treated with mastectomy without PMRT from 2005 to 2010 at 10 institutions. Univariate and multivariate analyses for locoregional recurrence (LRR) and any first recurrence (AFR) were performed according to clinicopathologic factors and biologic subtypes. Results: During a median follow-up period of 5.9 years (range: 0.7-10.4 years), 98 patients developed AFR (39 isolated LRR, 13 LRR with synchronous distant metastasis, and 46 isolated distant metastasis), and 52 patients developed LRR. The 7-year LRR and AFR rates were 3.8% and 6.7%, respectively. Multivariate analysis revealed that age of ≤ 40 years (p<0.001) and T2 stage (p=0.013) were independent risk factors for LRR. The 7-year LRR rates were 2.5% with no risk factors, 4.5% with one risk factor, and 12.4% with two risk factors. Multivariate analysis for AFR revealed that age of ≤ 40 years (p<0.001), T2 stage (p<0.001), and triple-negative biological subtype (p=0.045) were independent risk factors for AFR. The 7-year AFR rates were 3.9% with no risk factors, 8.4% with one risk factor, and 15.7% with two to three risk factors. Conclusions: Mastectomy without PMRT is a sufficient local treatment for pT1- 2N0M0 breast cancer. Nevertheless, PMRT might be considered for patients with two or three risk factors, among those of young age, with T2 tumors, and with the triplenegative biological subtype based on LRR and AFR.

KW - Breast cancer

KW - Post-mastectomy radiotherapy

KW - Risk factors

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U2 - 10.18632/oncotarget.16241

DO - 10.18632/oncotarget.16241

M3 - Article

AN - SCOPUS:85029072838

VL - 8

SP - 59800

EP - 59809

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

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