Possible association of the alpha-2A-adrenergic receptor gene with response time variability in attention deficit hyperactivity disorder

Soo Churl Cho, Jae Won Kim, Boong Nyun Kim, Jun Won Hwang, Mira Park, Soon Ae Kim, Dae Yeon Cho, Hee Jeong Yoo, Un Sun Chung, Jung Woo Son, Tae Won Park

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Previous studies have demonstrated that the MspI and DraI polymorphisms at the alpha-2A-adrenergic receptor gene (ADRA2A) are associated with ADHD. However, few studies have been designed to ascertain the association between the ADRA2A genotypes and the performance on neurocognitive measures in ADHD. The aims of this study were to examine the association of the ADRA2A MspI and DraI polymorphisms with ADHD in Korean subjects, and to determine the relationship between the genotypes of these two polymorphisms and the candidate endophenotypes, as measured by the continuous performance test (CPT). In a case-control study, we assessed 186 ADHD probands and 150 normal controls. One hundred eight trios were studied in a family based association analysis. The transmission disequilibrium test (TDT) analysis showed preferential transmission of the C allele of the DraI polymorphism (χ2 = 5.88, P = 0.015). In the haplotype analyses, a trend of over-transmission of haplotype C/C was observed (χ2 = 3.80, P = 0.051). The homozygous subjects for the C allele (C/C genotype) at the DraI polymorphism showed a trend toward a higher mean T-score with respect to the response time variability profiles of the CPT than did those with the other genotypes (C/T + T/T genotypes; P = 0.042). The homozygous subjects for the G allele (G/G genotype) at the MspI polymorphism showed a tendency to have a lower mean T-score with respect to the response time variability profiles of the CPT (P = 0.068). The results of this study provide important evidence for the involvement of the ADRA2A MspI and DraI polymorphisms in the etiology of ADHD in Korean subjects. In addition, our results provide evidence for the possible role of these two polymorphisms in ADHD symptom expression, such as increased response time variability.

Original languageEnglish
Pages (from-to)957-963
Number of pages7
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume147
Issue number6
DOIs
StatePublished - 5 Sep 2008

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Adrenergic alpha-2 Receptors
Attention Deficit Disorder with Hyperactivity
Reaction Time
Genotype
Genes
Alleles
Haplotypes
Endophenotypes
Case-Control Studies

Keywords

  • ADRA2A
  • Attention deficit hyperactivity disorder
  • Continuous performance test
  • Haplotype
  • Transmission disequilibrium

Cite this

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title = "Possible association of the alpha-2A-adrenergic receptor gene with response time variability in attention deficit hyperactivity disorder",
abstract = "Previous studies have demonstrated that the MspI and DraI polymorphisms at the alpha-2A-adrenergic receptor gene (ADRA2A) are associated with ADHD. However, few studies have been designed to ascertain the association between the ADRA2A genotypes and the performance on neurocognitive measures in ADHD. The aims of this study were to examine the association of the ADRA2A MspI and DraI polymorphisms with ADHD in Korean subjects, and to determine the relationship between the genotypes of these two polymorphisms and the candidate endophenotypes, as measured by the continuous performance test (CPT). In a case-control study, we assessed 186 ADHD probands and 150 normal controls. One hundred eight trios were studied in a family based association analysis. The transmission disequilibrium test (TDT) analysis showed preferential transmission of the C allele of the DraI polymorphism (χ2 = 5.88, P = 0.015). In the haplotype analyses, a trend of over-transmission of haplotype C/C was observed (χ2 = 3.80, P = 0.051). The homozygous subjects for the C allele (C/C genotype) at the DraI polymorphism showed a trend toward a higher mean T-score with respect to the response time variability profiles of the CPT than did those with the other genotypes (C/T + T/T genotypes; P = 0.042). The homozygous subjects for the G allele (G/G genotype) at the MspI polymorphism showed a tendency to have a lower mean T-score with respect to the response time variability profiles of the CPT (P = 0.068). The results of this study provide important evidence for the involvement of the ADRA2A MspI and DraI polymorphisms in the etiology of ADHD in Korean subjects. In addition, our results provide evidence for the possible role of these two polymorphisms in ADHD symptom expression, such as increased response time variability.",
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Possible association of the alpha-2A-adrenergic receptor gene with response time variability in attention deficit hyperactivity disorder. / Cho, Soo Churl; Kim, Jae Won; Kim, Boong Nyun; Hwang, Jun Won; Park, Mira; Kim, Soon Ae; Cho, Dae Yeon; Yoo, Hee Jeong; Chung, Un Sun; Son, Jung Woo; Park, Tae Won.

In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, Vol. 147, No. 6, 05.09.2008, p. 957-963.

Research output: Contribution to journalArticle

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AU - Cho, Soo Churl

AU - Kim, Jae Won

AU - Kim, Boong Nyun

AU - Hwang, Jun Won

AU - Park, Mira

AU - Kim, Soon Ae

AU - Cho, Dae Yeon

AU - Yoo, Hee Jeong

AU - Chung, Un Sun

AU - Son, Jung Woo

AU - Park, Tae Won

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AB - Previous studies have demonstrated that the MspI and DraI polymorphisms at the alpha-2A-adrenergic receptor gene (ADRA2A) are associated with ADHD. However, few studies have been designed to ascertain the association between the ADRA2A genotypes and the performance on neurocognitive measures in ADHD. The aims of this study were to examine the association of the ADRA2A MspI and DraI polymorphisms with ADHD in Korean subjects, and to determine the relationship between the genotypes of these two polymorphisms and the candidate endophenotypes, as measured by the continuous performance test (CPT). In a case-control study, we assessed 186 ADHD probands and 150 normal controls. One hundred eight trios were studied in a family based association analysis. The transmission disequilibrium test (TDT) analysis showed preferential transmission of the C allele of the DraI polymorphism (χ2 = 5.88, P = 0.015). In the haplotype analyses, a trend of over-transmission of haplotype C/C was observed (χ2 = 3.80, P = 0.051). The homozygous subjects for the C allele (C/C genotype) at the DraI polymorphism showed a trend toward a higher mean T-score with respect to the response time variability profiles of the CPT than did those with the other genotypes (C/T + T/T genotypes; P = 0.042). The homozygous subjects for the G allele (G/G genotype) at the MspI polymorphism showed a tendency to have a lower mean T-score with respect to the response time variability profiles of the CPT (P = 0.068). The results of this study provide important evidence for the involvement of the ADRA2A MspI and DraI polymorphisms in the etiology of ADHD in Korean subjects. In addition, our results provide evidence for the possible role of these two polymorphisms in ADHD symptom expression, such as increased response time variability.

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KW - Haplotype

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