Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population

A Multicenter Nationwide Study

Seon Hee Lim, Nayoung Kim, Jin Won Kwon, Sung Eun Kim, Gwang Ho Baik, Ju Yup Lee, Kyung Sik Park, Jeong Eun Shin, Hyun Joo Song, Dae Seong Myung, Suck Chei Choi, Hyun Jin Kim, Joo Hyun Lim, Jeong Yoon Yim, Joo-Sung Kim

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Background and Aim: Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population. Methods: Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria. Results: After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2% vs. 21.0%, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09–1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65 years old. Conclusions: H. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.

Original languageEnglish
Pages (from-to)2219-2230
Number of pages12
JournalDigestive Diseases and Sciences
Volume64
Issue number8
DOIs
StatePublished - 15 Aug 2019

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Helicobacter Infections
Helicobacter pylori
Multicenter Studies
Population
LDL Cholesterol
HDL Cholesterol
Body Mass Index
Cholesterol
Education
Stomach Diseases
Gastrointestinal Diseases
Waist Circumference
HDL Lipoproteins
Stomach
Cross-Sectional Studies
Immunoglobulin G
Smoking

Keywords

  • Cholesterol
  • Helicobacter pylori
  • Lipid profile
  • Metabolic syndrome

Cite this

Lim, Seon Hee ; Kim, Nayoung ; Kwon, Jin Won ; Kim, Sung Eun ; Baik, Gwang Ho ; Lee, Ju Yup ; Park, Kyung Sik ; Shin, Jeong Eun ; Song, Hyun Joo ; Myung, Dae Seong ; Choi, Suck Chei ; Kim, Hyun Jin ; Lim, Joo Hyun ; Yim, Jeong Yoon ; Kim, Joo-Sung. / Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population : A Multicenter Nationwide Study. In: Digestive Diseases and Sciences. 2019 ; Vol. 64, No. 8. pp. 2219-2230.
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title = "Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population: A Multicenter Nationwide Study",
abstract = "Background and Aim: Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population. Methods: Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria. Results: After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2{\%} in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2{\%} vs. 21.0{\%}, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95{\%} CI 1.09–1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65 years old. Conclusions: H. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.",
keywords = "Cholesterol, Helicobacter pylori, Lipid profile, Metabolic syndrome",
author = "Lim, {Seon Hee} and Nayoung Kim and Kwon, {Jin Won} and Kim, {Sung Eun} and Baik, {Gwang Ho} and Lee, {Ju Yup} and Park, {Kyung Sik} and Shin, {Jeong Eun} and Song, {Hyun Joo} and Myung, {Dae Seong} and Choi, {Suck Chei} and Kim, {Hyun Jin} and Lim, {Joo Hyun} and Yim, {Jeong Yoon} and Joo-Sung Kim",
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Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population : A Multicenter Nationwide Study. / Lim, Seon Hee; Kim, Nayoung; Kwon, Jin Won; Kim, Sung Eun; Baik, Gwang Ho; Lee, Ju Yup; Park, Kyung Sik; Shin, Jeong Eun; Song, Hyun Joo; Myung, Dae Seong; Choi, Suck Chei; Kim, Hyun Jin; Lim, Joo Hyun; Yim, Jeong Yoon; Kim, Joo-Sung.

In: Digestive Diseases and Sciences, Vol. 64, No. 8, 15.08.2019, p. 2219-2230.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population

T2 - A Multicenter Nationwide Study

AU - Lim, Seon Hee

AU - Kim, Nayoung

AU - Kwon, Jin Won

AU - Kim, Sung Eun

AU - Baik, Gwang Ho

AU - Lee, Ju Yup

AU - Park, Kyung Sik

AU - Shin, Jeong Eun

AU - Song, Hyun Joo

AU - Myung, Dae Seong

AU - Choi, Suck Chei

AU - Kim, Hyun Jin

AU - Lim, Joo Hyun

AU - Yim, Jeong Yoon

AU - Kim, Joo-Sung

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Background and Aim: Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population. Methods: Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria. Results: After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2% vs. 21.0%, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09–1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65 years old. Conclusions: H. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.

AB - Background and Aim: Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population. Methods: Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria. Results: After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2% vs. 21.0%, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09–1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65 years old. Conclusions: H. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.

KW - Cholesterol

KW - Helicobacter pylori

KW - Lipid profile

KW - Metabolic syndrome

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U2 - 10.1007/s10620-019-05544-3

DO - 10.1007/s10620-019-05544-3

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JO - Digestive diseases and sciences

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