Polymorphism of nine X chromosomal STR loci in Koreans

Jin Young Son, Yoon Seong Lee, Chong Min Choung, Soong Deok Lee

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

This study describes the polymorphism of the nine STR loci on the X chromosome, DXS6803, DXS8378, GATA164A09, DXS7132, DXS7133, DXS9895, DXS9898, DXS6789, and DXS6795 in Koreans. In each locus, 4-10 alleles were noted and the allelic distribution patterns were the same for males and females. Heterozygosity in females ranged from 0.42 to 0.84. Among the 303 father-daughter or mother-child pairs examined 29 cases of mutation were found, 13 at the DXS6803 locus, 2 at DXS8378, 4 at DXS164A09, 3 at DXS7132, 1 at DXS7133, 2 at DXS9895, 2 at DXS9898, 1 at DXS6789 and 1 at DXS6795. In 208 families including 180 fathers and 177 mothers, 530 different haplotypes were found. Unlike the STR loci on the Y chromosome, cases showing recombination were frequent, and in combination with mutation this made it difficult to discriminate the exclusion cases from those with mutation or recombination based on the haplotype. Details of X chromosomal STRs in Koreans which would be useful for a future large scale database are described.

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalInternational Journal of Legal Medicine
Volume116
Issue number6
StatePublished - 1 Dec 2002

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father
Fathers
Haplotypes
Mutation
Genetic Recombination
Mothers
exclusion
Y Chromosome
X Chromosome
Nuclear Family
Alleles
Databases

Keywords

  • Haplotype
  • Koreans
  • Polymorphism
  • Recombination
  • STR
  • X-chromosome

Cite this

Son, Jin Young ; Lee, Yoon Seong ; Choung, Chong Min ; Lee, Soong Deok. / Polymorphism of nine X chromosomal STR loci in Koreans. In: International Journal of Legal Medicine. 2002 ; Vol. 116, No. 6. pp. 317-321.
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abstract = "This study describes the polymorphism of the nine STR loci on the X chromosome, DXS6803, DXS8378, GATA164A09, DXS7132, DXS7133, DXS9895, DXS9898, DXS6789, and DXS6795 in Koreans. In each locus, 4-10 alleles were noted and the allelic distribution patterns were the same for males and females. Heterozygosity in females ranged from 0.42 to 0.84. Among the 303 father-daughter or mother-child pairs examined 29 cases of mutation were found, 13 at the DXS6803 locus, 2 at DXS8378, 4 at DXS164A09, 3 at DXS7132, 1 at DXS7133, 2 at DXS9895, 2 at DXS9898, 1 at DXS6789 and 1 at DXS6795. In 208 families including 180 fathers and 177 mothers, 530 different haplotypes were found. Unlike the STR loci on the Y chromosome, cases showing recombination were frequent, and in combination with mutation this made it difficult to discriminate the exclusion cases from those with mutation or recombination based on the haplotype. Details of X chromosomal STRs in Koreans which would be useful for a future large scale database are described.",
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Son, JY, Lee, YS, Choung, CM & Lee, SD 2002, 'Polymorphism of nine X chromosomal STR loci in Koreans', International Journal of Legal Medicine, vol. 116, no. 6, pp. 317-321.

Polymorphism of nine X chromosomal STR loci in Koreans. / Son, Jin Young; Lee, Yoon Seong; Choung, Chong Min; Lee, Soong Deok.

In: International Journal of Legal Medicine, Vol. 116, No. 6, 01.12.2002, p. 317-321.

Research output: Contribution to journalArticleResearchpeer-review

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